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ONTOLOGY REPORT - ANNOTATIONS

Term:hypoxia-inducible factor-proline dioxygenase activity
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Accession:GO:0160082 term browser browse the term
Definition:Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit].
Synonyms:exact_synonym: HIF prolyl hydroxylase
 broad_synonym: HIF hydroxylase
 xref: EC:1.14.11.29;   RHEA:48400


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hypoxia-inducible factor-proline dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGLN1 egl-9 family hypoxia inducible factor 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:8,053,486...8,110,791
Ensembl chr 4:8,053,837...8,109,325 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18798
    catalytic activity 5740
      catalytic activity, acting on a protein 2372
        peptidyl-proline dioxygenase activity 12
          peptidyl-proline 4-dioxygenase activity 8
            hypoxia-inducible factor-proline dioxygenase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 18798
    catalytic activity 5740
      oxidoreductase activity 780
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 197
          2-oxoglutarate-dependent dioxygenase activity 71
            peptidyl-proline dioxygenase activity 12
              peptidyl-proline 4-dioxygenase activity 8
                hypoxia-inducible factor-proline dioxygenase activity 1
paths to the root