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ONTOLOGY REPORT - ANNOTATIONS

Term:peptidyl-proline dioxygenase activity
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Accession:GO:0031543 term browser browse the term
Definition:Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.
Synonyms:broad_synonym: proline hydroxylase activity;   proline,2-oxoglutarate 4-dioxygenase activity;   prolyl 4-hydroxylase activity;   prolyl hydroxylase activity


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peptidyl-proline dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egln1 egl-9 family hypoxia-inducible factor 1 IDA RGD PMID:20308610 PMID:18640395 RGD:6483365, RGD:6483450 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 enables ISO (PMID:24030251) RGD PMID:24030251 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 enables ISO
IBA		 (PMID:24550447)
GO_REF:0000033		 RGD
GO_Central		 PMID:24550447 GO_REF:0000033 NCBI chr19:10,945,031...10,974,602
Ensembl chr19:10,946,018...10,975,119 		JBrowse link
hypoxia-inducible factor-proline dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egln1 egl-9 family hypoxia-inducible factor 1 enables IEA
ISO		 GO_REF:0000107
(PMID:11598268)		 Ensembl
RGD		 PMID:11598268 GO_REF:0000107 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
peptidyl-proline 3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 enables ISO (PMID:24550447), (PMID:24550462) RGD PMID:24550447 PMID:24550462 NCBI chr19:10,945,031...10,974,602
Ensembl chr19:10,946,018...10,975,119 		JBrowse link
peptidyl-proline 4-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egln1 egl-9 family hypoxia-inducible factor 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 enables ISO
IEA
IBA
IDA		 (PMID:11598268), (PMID:12039559)
GO_REF:0000107
GO_REF:0000033
PMID:15925519		 RGD
Ensembl
GO_Central		 PMID:11598268 PMID:12039559 PMID:15925519 GO_REF:0000033 GO_REF:0000107, RGD:13602003 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 enables ISO
IEA
IBA		 (PMID:11598268)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:11598268 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
procollagen-proline 3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P3h1 prolyl 3-hydroxylase 1 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000003 GO_REF:0000033 NCBI chr 5:132,841,868...132,856,664
Ensembl chr 5:132,841,928...132,856,659 		JBrowse link
G P3h2 prolyl 3-hydroxylase 2 enables ISS
IBA
ISO
IEA
IDA		 GO_REF:0000024
GO_REF:0000033
(PMID:18487197)
GO_REF:0000003
PMID:21757687		 UniProt
GO_Central
RGD		 PMID:18487197 PMID:21757687 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033, RGD:8553392 NCBI chr11:74,634,267...74,775,422
Ensembl chr11:74,634,267...74,775,421 		JBrowse link
G P3h3 prolyl 3-hydroxylase 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:157,646,242...157,662,035
Ensembl chr 4:157,646,243...157,662,035 		JBrowse link
procollagen-proline 4-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 enables TAS
ISO
IBA
IEA
ISS		 MGI:3706369 (PMID:17135260), (PMID:7753822)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000024
(PMID:9211872)		 RGD
GO_Central
InterPro
UniProt		 PMID:7753822 PMID:9211872 PMID:17135260 PMID:11997102 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033, RGD:625562 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786 		JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 enables ISO
IBA		 (PMID:9211872)
(PMID:7753822)
GO_REF:0000033		 RGD
GO_Central		 PMID:7753822 PMID:9211872 GO_REF:0000033 NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314 		JBrowse link
G P4ha3 prolyl 4-hydroxylase subunit alpha 3 enables IMP
IBA
IEA		 GO_REF:0000033
GO_REF:0000002
GO_REF:0000003		 GO_Central
InterPro
UniProt
RGD		 PMID:14500733 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033, RGD:731224 NCBI chr 1:154,628,723...154,663,779
Ensembl chr 1:154,628,736...154,663,775 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta contributes_to ISO (PMID:7753822) RGD PMID:7753822 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G P4htm prolyl 4-hydroxylase, transmembrane enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:109,274,629...109,292,802
Ensembl chr 8:109,274,626...109,292,473 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      catalytic activity, acting on a protein 2509
        peptidyl-proline dioxygenase activity 12
          peptidyl-proline 3-dioxygenase activity + 4
          peptidyl-proline 4-dioxygenase activity + 8
          procollagen-proline dioxygenase activity + 8
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 238
          2-oxoglutarate-dependent dioxygenase activity 63
            peptidyl-proline dioxygenase activity 12
              peptidyl-proline 3-dioxygenase activity + 4
              peptidyl-proline 4-dioxygenase activity + 8
              procollagen-proline dioxygenase activity + 8
paths to the root