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ONTOLOGY REPORT - ANNOTATIONS

Term:EGAD pathway
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Accession:GO:0140624 term browser browse the term
Definition:The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation.


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Term Annotations click to browse term
  biological_process 20115
    metabolic process 12288
      catabolic process 2807
        macromolecule catabolic process 1583
          protein catabolic process 1108
            proteasomal protein catabolic process 548
              EGAD pathway 0
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12288
      macromolecule metabolic process 10146
        protein metabolic process 5693
          proteolysis 1814
            proteolysis involved in protein catabolic process 827
              proteasomal protein catabolic process 548
                EGAD pathway 0
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