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ONTOLOGY REPORT - ANNOTATIONS

Term:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
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Accession:GO:0047238 term browser browse the term
Definition:Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP.
Synonyms:exact_synonym: N-acetylgalactosaminyltransferase II activity;   glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;   glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity
 related_synonym: UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity;   UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;   chondroitin synthase activity;   uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity
 xref: EC:2.4.1.175;   MetaCyc:RXN-16325;   Reactome:R-HSA-1971487 "CHPF,CHSY3 transfer GalNAc to chondroitin";   Reactome:R-HSA-3595176 "Defective CHSY1 does not transfer GalNAc to chondroitin";   Reactome:R-HSA-9632033 "CHSY1 transfers GalNAc to chondroitin";   reactome:R-HSA-1971482 "The addition of GalNAc to the terminal glucuronate residue forms chondroitin"


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glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHPF chondroitin polymerizing factor enables TAS
IBA
IEA
IDA		 (PMID:12761225) Reactome
GO_Central
Ensembl
UniProt
FlyBase		 PMID:12761225 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 Reactome:R-HSA-1971487 NCBI chr 2:219,538,954...219,543,809
Ensembl chr 2:219,538,954...219,543,809 		JBrowse link
G CHPF2 chondroitin polymerizing factor 2 enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:151,232,483...151,238,822
Ensembl chr 7:151,232,483...151,240,979 		JBrowse link
G CHSY1 chondroitin sulfate synthase 1 enables IDA
IEA
IBA
TAS		 (PMID:11514575) MGI
TreeGrafter
GO_Central
Ensembl
Reactome
UniProt		 PMID:11514575 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 Reactome:R-HSA-3595176 Reactome:R-HSA-9632033 NCBI chr15:101,175,727...101,252,048
Ensembl chr15:101,175,727...101,252,048 		JBrowse link
G CHSY3 chondroitin sulfate synthase 3 enables IEA
IBA
TAS		 UniProt
GO_Central
TreeGrafter
Ensembl
Reactome		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 Reactome:R-HSA-1971487 NCBI chr 5:129,903,979...130,186,634
Ensembl chr 5:129,904,465...130,186,634 		JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 enables TAS
IBA
IEA
IDA		 (PMID:12163485) Reactome
GO_Central
Ensembl
UniProt		 PMID:12163485 GO_REF:0000033 GO_REF:0000107 Reactome:R-HSA-1971482 NCBI chr 8:19,404,161...19,757,908
Ensembl chr 8:19,404,161...19,758,029 		JBrowse link
G CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 enables TAS
IEA
IBA		 Reactome
Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 Reactome:R-HSA-1971482 NCBI chr10:43,138,445...43,185,308
Ensembl chr10:43,138,445...43,185,302 		JBrowse link
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  molecular_function 19489
    catalytic activity 5987
      transferase activity 2465
        glycosyltransferase activity 290
          hexosyltransferase activity 210
            acetylgalactosaminyltransferase activity 35
              glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity 6
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