24-hydroxycholesterol 7alpha-hydroxylase activity - Ontology Report

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Term:	24-hydroxycholesterol 7alpha-hydroxylase activity	go back to main search page
Accession:	GO:0033782	browse the term
Definition:	Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase].
Comment:	Formerly EC:1.14.13.99.
Synonyms:	related_synonym:	24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity; 24-hydroxycholesterol 7alpha-monooxygenase activity
	xref:	EC:1.14.14.26; KEGG_REACTION:R07208; MetaCyc:1.14.13.99-RXN; RHEA:46124

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Genes (1)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cyp7a1

cytochrome P450 family 7 subfamily A member 1

enables

GO_REF:0000003
GO_REF:0000116

GO_REF:0000003 GO_REF:0000116

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

Term paths to the root

Path 1
Term	Annotations
molecular_function	20487
catalytic activity	6037
oxidoreductase activity	851
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	238
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	69
24-hydroxycholesterol 7alpha-hydroxylase activity	1

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