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ONTOLOGY REPORT - ANNOTATIONS

Term:response to methotrexate
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Accession:GO:0031427 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.


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response to methotrexate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    response to stimulus 10517
      response to chemical 5925
        response to oxygen-containing compound 2397
          response to methotrexate 1
            cellular response to methotrexate 0
Path 2
Term Annotations click to browse term
  biological_process 19694
    response to stimulus 10517
      response to chemical 5925
        response to organic substance 3641
          response to organonitrogen compound 1424
            response to methotrexate 1
              cellular response to methotrexate 0
paths to the root