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ONTOLOGY REPORT - ANNOTATIONS

Term:type I hypersensitivity
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Accession:GO:0016068 term browser browse the term
Definition:An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
Comment:Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.
Synonyms:exact_synonym: immediate hypersensitivity response
 xref: Wikipedia:Type_I_hypersensitivity

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type I hypersensitivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1a Fc fragment of IgE receptor Ia involved_in ISO (PMID:8551243) UniProt PMID:8551243 NCBI chrNW_004624794:2,003,031...2,008,930
Ensembl chrNW_004624794:2,002,928...2,008,940 		JBrowse link
negative regulation of type I hypersensitivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr2b Fc fragment of IgG receptor IIb acts_upstream_of_or_within ISO (PMID:8552190) MGI PMID:8552190 NCBI chrNW_004624826:97,605...112,101 JBrowse link
positive regulation of type I hypersensitivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase ISO RGD PMID:22228807 RGD:11040701 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia acts_upstream_of_or_within ISO (PMID:8252632) MGI PMID:8252632 NCBI chrNW_004624794:2,003,031...2,008,930
Ensembl chrNW_004624794:2,002,928...2,008,940 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (PMID:14764707) MGI PMID:14764707 NCBI chrNW_004624794:168,564...172,433
Ensembl chrNW_004624794:168,564...172,034 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      immune response 1306
        inflammatory response to antigenic stimulus 73
          acute inflammatory response to antigenic stimulus 32
            hypersensitivity 15
              type I hypersensitivity 4
                negative regulation of type I hypersensitivity 1
                positive regulation of type I hypersensitivity 3
                regulation of type I hypersensitivity + 4
                type I hypersensitivity mediated by basophils 0
                type I hypersensitivity mediated by mast cells 0
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8161
      response to stress 3540
        defense response 1409
          inflammatory response 673
            inflammatory response to antigenic stimulus 73
              acute inflammatory response to antigenic stimulus 32
                hypersensitivity 15
                  type I hypersensitivity 4
                    negative regulation of type I hypersensitivity 1
                    positive regulation of type I hypersensitivity 3
                    regulation of type I hypersensitivity + 4
                    type I hypersensitivity mediated by basophils 0
                    type I hypersensitivity mediated by mast cells 0
paths to the root