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ONTOLOGY REPORT - ANNOTATIONS

Term:methotrexate transmembrane transporter activity
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Accession:GO:0015350 term browser browse the term
Definition:Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
Synonyms:related_synonym: methotrexate transporter activity


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methotrexate transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC19A1 solute carrier family 19 member 1 enables IEA UniProt
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr21:31,836,774...31,883,829
Ensembl chr21:45,090,595...45,134,752 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr17:28,367,674...28,379,618
Ensembl chr17:28,870,678...28,877,632 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17494
    transporter activity 1158
      transmembrane transporter activity 1070
        amide transmembrane transporter activity 43
          methotrexate transmembrane transporter activity 2
Path 2
Term Annotations click to browse term
  molecular_function 17494
    transporter activity 1158
      transmembrane transporter activity 1070
        organic acid transmembrane transporter activity 181
          carboxylic acid transmembrane transporter activity 180
            dicarboxylic acid transmembrane transporter activity 31
              methotrexate transmembrane transporter activity 2
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