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ONTOLOGY REPORT - ANNOTATIONS

Term:oxysterol 7-alpha-hydroxylase activity
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Accession:GO:0008396 term browser browse the term
Definition:Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O.
Synonyms:narrow_synonym: cytochrome P450 CYP7B1
 xref: Reactome:R-HSA-5602885 "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL";   reactome:R-HSA-191972 "27-hydroxycholesterol is 7alpha-hydroxylated";   reactome:R-HSA-192065 "CYP7B1 7-hydroxylates 25OH-CHOL";   reactome:R-HSA-192178 "CYP39A1 7-hydroxylates 24OH-CHOL"


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oxysterol 7-alpha-hydroxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 enables ISO
IBA		 (PMID:10748047)
(MGI:1859119|PMID:10748047)
GO_REF:0000033		 RGD
GO_Central		 PMID:10748047 GO_REF:0000033 MGI:1859119 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 enables TAS
IBA
ISO
IEA
ISS		 GO_REF:0000033
(MGI:1859119|PMID:10748047), (MGI:5440118|PMID:22999953)
GO_REF:0000107
GO_REF:0000024		 GO_Central
RGD
Ensembl
UniProt		 PMID:10748047 PMID:22999953 PMID:12029625 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:1859119 MGI:5440118, RGD:1298868 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      oxidoreductase activity 850
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 238
          oxysterol 7-alpha-hydroxylase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      oxidoreductase activity 850
        monooxygenase activity 159
          steroid hydroxylase activity 35
            oxysterol 7-alpha-hydroxylase activity 2
paths to the root