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ONTOLOGY REPORT - ANNOTATIONS

Term:signal recognition particle, endoplasmic reticulum targeting
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Accession:GO:0005786 term browser browse the term
Definition:A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.
Synonyms:exact_synonym: SRP;   signal sequence receptor complex
 alt_id: GO:0005855
 xref: Wikipedia:Signal_recognition_particle
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


show annotations for term's descendants           Sort by:
signal recognition particle, endoplasmic reticulum targeting term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000062486 part_of IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr18:25,931,666...25,951,758 JBrowse link
G ENSRNOG00000065388 part_of IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr14:18,768,039...18,769,105 JBrowse link
G LOC120099767 signal recognition particle subunit SRP72-like part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:75,982,366...75,984,490 JBrowse link
G Srp14 signal recognition particle 14 part_of ISO
IBA		 (PMID:18089836)
GO_REF:0000033		 RGD
GO_Central		 PMID:18089836 GO_REF:0000033 NCBI chr 3:105,442,184...105,445,875
Ensembl chr 3:105,442,198...105,445,859 		JBrowse link
G Srp14l1 signal recognition particle 14 like 1 part_of IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 9:86,645,829...86,649,077
Ensembl chr 9:86,647,223...86,647,627 		JBrowse link
G Srp19 signal recognition particle 19 part_of ISO
IBA		 (PMID:18089836)
GO_REF:0000033		 RGD
GO_Central		 PMID:18089836 GO_REF:0000033 NCBI chr18:25,931,734...25,937,974
Ensembl chr18:25,931,589...25,938,017 		JBrowse link
G Srp54a signal recognition particle 54A part_of ISO
IEA
IBA		 (PMID:18089836)
GO_REF:0000104
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:18089836 GO_REF:0000033 GO_REF:0000104 NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189 		JBrowse link
G Srp68 signal recognition particle 68 part_of ISO
IBA		 (PMID:18089836)
GO_REF:0000033		 RGD
GO_Central		 PMID:18089836 GO_REF:0000033 NCBI chr10:101,481,213...101,508,035
Ensembl chr10:101,481,212...101,508,035 		JBrowse link
G Srp72 signal recognition particle 72 part_of ISO
IBA		 (PMID:18089836)
GO_REF:0000033		 RGD
GO_Central		 PMID:18089836 GO_REF:0000033 NCBI chr14:31,168,175...31,195,717
Ensembl chr14:31,168,293...31,195,729 		JBrowse link
G Srp9 signal recognition particle 9 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20969
    cellular anatomical structure 20768
      cytoplasm 11977
        signal recognition particle 10
          signal recognition particle, endoplasmic reticulum targeting 10
Path 2
Term Annotations click to browse term
  cellular_component 20969
    cellular anatomical structure 20768
      intracellular anatomical structure 15297
        cytoplasm 11977
          signal recognition particle 10
            signal recognition particle, endoplasmic reticulum targeting 10
paths to the root