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ONTOLOGY REPORT - ANNOTATIONS

Term:tryptophan-tRNA ligase activity
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Accession:GO:0004830 term browser browse the term
Definition:Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
Synonyms:exact_synonym: tryptophanyl-tRNA synthetase activity
 related_synonym: L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity;   L-tryptophan-tRNATrp ligase (AMP-forming);   TrpRS activity;   tryptophan translase activity;   tryptophanyl ribonucleic synthetase activity;   tryptophanyl-tRNA synthase activity;   tryptophanyl-transfer RNA synthetase activity;   tryptophanyl-transfer ribonucleate synthetase activity;   tryptophanyl-transfer ribonucleic acid synthetase activity;   tryptophanyl-transfer ribonucleic synthetase activity
 xref: EC:6.1.1.2;   MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN;   RHEA:24080;   reactome:R-HSA-379977 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate";   reactome:R-HSA-380222 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate"


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tryptophan-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wars1 tryptophanyl-tRNA synthetase 1 enables IEA
ISO
ISS
IBA		 GO_REF:0000003
(PMID:28369220)
GO_REF:0000024
GO_REF:0000033
(PMID:12060739), (PMID:19941862)		 UniProt
RGD
GO_Central		 PMID:12060739 PMID:19941862 PMID:28369220 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) enables ISO
IBA		 (PMID:10828066)
GO_REF:0000033		 RGD
GO_Central		 PMID:10828066 GO_REF:0000033 NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20626
    catalytic activity 6028
      ligase activity 178
        ligase activity, forming carbon-oxygen bonds 45
          aminoacyl-tRNA ligase activity 45
            tryptophan-tRNA ligase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 20626
    catalytic activity 6028
      catalytic activity, acting on a nucleic acid 649
        catalytic activity, acting on RNA 397
          catalytic activity, acting on a tRNA 136
            aminoacyl-tRNA ligase activity 45
              tryptophan-tRNA ligase activity 2
paths to the root