prostaglandin-endoperoxide synthase activity - Ontology Report

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Term:	prostaglandin-endoperoxide synthase activity	go back to main search page
Accession:	GO:0004666	browse the term
Definition:	Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
Synonyms:	related_synonym:	(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity; (PG)H synthase activity; PG synthetase activity; fatty acid cyclooxygenase activity; prostaglandin G/H synthase activity; prostaglandin endoperoxide synthetase activity; prostaglandin synthase activity; prostaglandin synthetase activity
	xref:	EC:1.14.99.1; MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN; RHEA:23728; reactome:R-HSA-140355 "Arachidonic acid is oxidised to PGG2 by PTGS1"; reactome:R-HSA-2309787 "Arachidonic acid is oxidised to PGG2 by PTGS2"

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Genes (2)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ptgs1

prostaglandin-endoperoxide synthase 1

enables

(PMID:1380156)
GO_REF:0000003
GO_REF:0000033

GO_REF:0000003 GO_REF:0000033

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

prostaglandin-endoperoxide synthase 2

enables

GO_REF:0000024
(PMID:1380156), (PMID:16373578), (PMID:7592599), (PMID:7947975)
GO_REF:0000033
(MGI:5315361|PMID:12925531), (PMID:1419907)

GO_REF:0000024 GO_REF:0000033 MGI:5315361

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

Term paths to the root

Path 1
Term	Annotations
molecular_function	20483
catalytic activity	6036
oxidoreductase activity	850
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	238
prostaglandin-endoperoxide synthase activity	2

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