Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:steroid 17-alpha-monooxygenase activity
go back to main search page
Accession:GO:0004508 term browser browse the term
Definition:Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase].
Synonyms:exact_synonym: steroid 17-alpha-hydroxylase activity;   steroid 17-alpha-hydroxylase-C17-20 lyase activity
 narrow_synonym: cytochrome P450 CYP17;   cytochrome p450 XVIIA1 activity
 related_synonym: 17alpha-hydroxylase-C17,20 lyase activity;   cytochrome P-450 (P-45017alpha,lyase);   cytochrome P45017alpha;   steroid 17-alpha-hydroxylase/17,20 lyase activity;   steroid 17alpha-hydroxylase activity;   steroid 17alpha-monooxygenase activity;   steroid 17alphahydroxylase/17,20 lyase activity;   steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
 xref: EC:1.14.14.19;   MetaCyc:4.1.2.30-RXN;   MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN;   RHEA:65760;   Reactome:R-HSA-193070 "CYP17A1 cleaves 17aHPREG to DHA";   Reactome:R-HSA-193072 "CYP17A1 17-hydroxylates P4 to 17aHPROG";   Reactome:R-HSA-5601843 "Defective CYP17A1 does not 17-hydroxylate PREG";   Reactome:R-HSA-9035954 "Defective CYP17A1 does not 17-hydroxylate P4";   Reactome:R-HSA-9035956 "Defective CYP17A1 does not cleave 17aHPROG";   reactome:R-HSA-193068 "CYP17A1 17-hydroxylates PREG";   reactome:R-HSA-193099 "CYP17A1 cleaves 17aHPROG to ANDST"


show annotations for term's descendants           Sort by:
steroid 17-alpha-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 enables TAS
IDA
IEA
ISO
IBA		 GO_REF:0000107
(PMID:22170710), (PMID:22266943), (PMID:24140098), (PMID:36640554)
GO_REF:0000033
MGI:3047328 (MGI:7510298|PMID:36640554), (PMID:15169901), (PMID:7588219)		 Ensembl
RGD
GO_Central		 PMID:7588219 PMID:15169901 PMID:22170710 PMID:22266943 PMID:24140098 More... GO_REF:0000033 GO_REF:0000107 MGI:7510298, RGD:1298833, RGD:1298835 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      oxidoreductase activity 850
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 238
          steroid 17-alpha-monooxygenase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      oxidoreductase activity 850
        monooxygenase activity 159
          steroid hydroxylase activity 35
            steroid 17-alpha-monooxygenase activity 1
paths to the root