kynurenine 3-monooxygenase activity - Ontology Report

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Term:	kynurenine 3-monooxygenase activity	go back to main search page
Accession:	GO:0004502	browse the term
Definition:	Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+.
Synonyms:	exact_synonym:	kynurenine 3-hydroxylase activity
	related_synonym:	L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating); L-kynurenine-3-hydroxylase activity; kynurenine hydroxylase activity
	xref:	EC:1.14.13.9; KEGG_REACTION:R01960; MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN; RHEA:20545; reactome:R-HSA-71200 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O"

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Genes (1)

kynurenine 3-monooxygenase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Kmo

kynurenine 3-monooxygenase

enables

IDA
ISO
IEA
IBA

(PMID:10672018), (PMID:23575632), (PMID:26752518), (PMID:29208702), (PMID:29429898), (PMID:9237672)
PMID:1332540
GO_REF:0000104
GO_REF:0000033
(PMID:26752518)

RGD
UniProt
GO_Central

PMID:9237672 PMID:10672018 PMID:23575632 PMID:26752518 PMID:29208702 More...

GO_REF:0000033 GO_REF:0000104, RGD:2290309, RGD:2290310, RGD:2290313, RGD:11342439, RGD:8554522

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

Term paths to the root

Path 1
Term	Annotations
molecular_function	20807
catalytic activity	6119
oxidoreductase activity	861
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	241
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	39
kynurenine 3-monooxygenase activity	1

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ONTOLOGY REPORT - ANNOTATIONS