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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA-directed DNA polymerase activity
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Accession:GO:0003964 term browser browse the term
Definition:Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
Synonyms:narrow_synonym: RNA-directed DNA polymerase, group II intron encoded;   RNA-directed DNA polymerase, transposon encoded
 related_synonym: DNA nucleotidyltransferase (RNA-directed) activity;   RNA revertase activity;   RNA-dependent DNA polymerase activity;   RNA-dependent deoxyribonucleate nucleotidyltransferase activity;   RNA-instructed DNA polymerase activity;   RT;   deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity;   reverse transcriptase activity;   revertase activity
 xref: EC:2.7.7.49;   MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN;   reactome:R-HSA-164504 "Synthesis of minus strand strong stop DNA (-sssDNA)";   reactome:R-HSA-164520 "Minus strand DNA synthesis resumes"


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RNA-directed DNA polymerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terc telomerase RNA component contributes_to ISO (PMID:19701182) BHF-UCL PMID:19701182 NCBI chr 3:96,321,753...96,322,149
Ensembl chr 3:96,321,753...96,322,149 		JBrowse link
G Tert telomerase reverse transcriptase enables ISO GO_Central GO_REF:0000119 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
telomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkc1 dyskeratosis congenita 1, dyskerin enables
contributes_to		 ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr  X:74,139,460...74,153,382
Ensembl chr  X:74,139,460...74,153,383 		JBrowse link
G Ptges3 prostaglandin E synthase 3 enables ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141 		JBrowse link
G Ptges3-ps prostaglandin E synthase 3, pseudogene enables ISO GO_Central GO_REF:0000119 NCBI chr 6:85,820,803...85,822,372
Ensembl chr 6:85,820,962...85,821,441 		JBrowse link
G Tep1 telomerase associated protein 1 contributes_to ISO
IBA
IDA		 (PMID:9020079) GO_Central
BHF-UCL		 PMID:9020079 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 NCBI chr14:51,061,513...51,108,036
Ensembl chr14:51,061,516...51,108,017 		JBrowse link
G Terc telomerase RNA component enables
contributes_to		 IMP
ISO		 (PMID:17982445)
(PMID:11313459)
(PMID:16507993), (PMID:17940095), (PMID:18082603), (PMID:19701182), (PMID:9398860), (PMID:9443919)		 MGI
BHF-UCL		 PMID:9398860 PMID:9443919 PMID:11313459 PMID:16507993 PMID:17940095 More... NCBI chr 3:96,321,753...96,322,149
Ensembl chr 3:96,321,753...96,322,149 		JBrowse link
G Terf1 telomeric repeat binding factor 1 contributes_to
enables		 IBA
ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 1:15,875,634...15,914,283
Ensembl chr 1:15,875,870...15,914,276 		JBrowse link
G Terf2 telomeric repeat binding factor 2 contributes_to
enables		 IBA
ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 8:107,796,032...107,823,180
Ensembl chr 8:107,796,032...107,823,179 		JBrowse link
G Tert telomerase reverse transcriptase enables IDA
IBA
ISO
TAS		 (PMID:14701760)
(PMID:16107853)		 MGI
GO_Central
BHF-UCL
RGD		 PMID:9665809 PMID:14701760 PMID:16107853 GO_REF:0000033 GO_REF:0000119 RGD:405878064 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
template for synthesis of G-rich strand of telomere DNA activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terc telomerase RNA component enables ISO (PMID:17940095), (PMID:19701182), (PMID:9398860) BHF-UCL PMID:9398860 PMID:17940095 PMID:19701182 NCBI chr 3:96,321,753...96,322,149
Ensembl chr 3:96,321,753...96,322,149 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28796
    catalytic activity 5725
      catalytic activity, acting on a nucleic acid 647
        catalytic activity, acting on DNA 326
          DNA polymerase activity 30
            RNA-directed DNA polymerase activity 8
              telomerase activity + 8
Path 2
Term Annotations click to browse term
  molecular_function 28796
    catalytic activity 5725
      transferase activity 2281
        transferase activity, transferring phosphorus-containing groups 913
          nucleotidyltransferase activity 142
            DNA polymerase activity 30
              RNA-directed DNA polymerase activity 8
                telomerase activity + 8
paths to the root