immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor - Ontology Report

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Term:	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	go back to main search page
Accession:	GO:0002415	browse the term
Definition:	The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
Synonyms:	exact_synonym:	antibody transcytosis mediated by pIgR; immunoglobulin transcytosis mediated by pIgR

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Genes (2)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Pigr

polymeric immunoglobulin receptor

involved_in

GO_REF:0000107
GO_REF:0000024
(PMID:10229845), (PMID:22022593), (PMID:9379029)
GO_REF:0000033

GO_REF:0000024 GO_REF:0000033 GO_REF:0000107

NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875

RAB17, member RAS oncogene family

involved_in

(PMID:9624171)

NCBI chr 9:91,552,924...91,566,759
Ensembl chr 9:91,553,464...91,566,451

Term paths to the root

Path 1
Term	Annotations
biological_process	20075
multicellular organismal process	8904
transcytosis	26
immunoglobulin transcytosis in epithelial cells	4
immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	2
Path 2
Term	Annotations
biological_process	20075
localization	5699
establishment of localization	5002
transport	4697
vesicle-mediated transport	1632
transcytosis	26
immunoglobulin transcytosis in epithelial cells	4
immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	2

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