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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hydatidiform Mole, Invasive
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Accession:DOID:9007998 term browser browse the term
Definition:A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.
Synonyms:exact_synonym: Chorioadenoma;   Chorioadenomas;   Invasive Hydatidiform Moles;   Invasive Mole;   Invasive Moles
 primary_id: MESH:D002820;   RDO:0005203

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Hydatidiform Mole, Invasive term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msh2 mutS homolog 2 ISO protein:decreased expression:mononuclear cytotrophoblast cell RGD PMID:15338238 RGD:2293517 NCBI chrNW_004955441:14,188,315...14,247,608
Ensembl chrNW_004955441:14,187,805...14,247,698 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14316
    disease of cellular proliferation 6918
      Neoplastic Pregnancy Complications 16
        trophoblastic neoplasm 16
          gestational trophoblastic neoplasm 9
            Hydatidiform Mole 8
              Hydatidiform Mole, Invasive 1
Path 2
Term Annotations click to browse term
  disease 14316
    disease of anatomical entity 14023
      Urogenital Diseases 4543
        Female Urogenital Diseases and Pregnancy Complications 2390
          Female Urogenital Diseases 1989
            female reproductive system disease 1986
              uterine disease 464
                endometrial disease 261
                  Endometrial Neoplasms 251
                    endometrial cancer 180
                      gestational trophoblastic neoplasm 9
                        Hydatidiform Mole 8
                          Hydatidiform Mole, Invasive 1
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