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gastrinoma - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:gastrinoma
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Accession:DOID:5577 term browser browse the term
Definition:A neuroendocrine tumor that results_in an overproduction of gastric acid. (DO)
Synonyms:exact_synonym: Gastrin Producing Tumor;   Gastrin-Producing Tumors;   Gastrinomas;   Ulcerogenic Islet Cell Tumor;   gastrin cell tumour;   gastrin secreting tumor;   malignant gastrinoma
 primary_id: MESH:D015408
 xref: ICDO:8153/3;   NCI:C3050
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gastrinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1r insulin like growth factor 1 receptor ISO mRNA and protein: increased expression::poor prognosis for high expression RGD PMID:15867218 RGD:7242847 NCBI chrNW_004624768:5,396,027...5,688,435
Ensembl chrNW_004624768:5,396,156...5,681,809 		JBrowse link
G Men1 menin 1 ISO CTD Direct Evidence: marker/mechanism
DNA:mutations: : 		CTD
RGD		 PMID:15944766 PMID:17961653 RGD:2317354 NCBI chrNW_004624767:21,579,084...21,585,380
Ensembl chrNW_004624767:21,579,103...21,585,373 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase severity ISO associated with Zollinger-Ellison Syndrome; mRNA:increased expression:tumor (human) RGD PMID:12114431 RGD:2317605 NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase ISO DNA:hypomethylation:promoter (human) RGD PMID:17278096 RGD:2317340 NCBI chrNW_004624737:17,271,881...17,619,123
Ensembl chrNW_004624737:17,271,992...17,528,889 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 ISO mRNA:decreased expression:pancreatic islet RGD PMID:8421107 PMID:12114701 RGD:2324976 RGD:2324977 NCBI chrNW_004624730:49,026,603...49,056,363
Ensembl chrNW_004624730:49,025,766...49,056,284 		JBrowse link
duodenal gastrinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Men1 menin 1 ISO associated with Neuroendocrine Tumors; DNA:loss of heterozygosity: : RGD PMID:17135306 RGD:2317341 NCBI chrNW_004624767:21,579,084...21,585,380
Ensembl chrNW_004624767:21,579,103...21,585,373 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14231
    disease of anatomical entity 13933
      endocrine system disease 5726
        endocrine gland cancer 2269
          neuroendocrine tumor 193
            gastrinoma 5
              duodenal gastrinoma 1
              gastric gastrinoma 0
Path 2
Term Annotations click to browse term
  disease 14231
    disease of anatomical entity 13933
      nervous system disease 12273
        Nervous System Neoplasms 1412
          nervous system cancer 806
            neuroectodermal tumor 425
              neuroendocrine tumor 193
                islet cell tumor 27
                  pancreatic endocrine carcinoma 12
                    gastrinoma 5
                      duodenal gastrinoma 1
                      gastric gastrinoma 0
paths to the root