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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:brain glioblastoma multiforme
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Accession:DOID:3073 term browser browse the term
Definition:A brain glioma that has_material_basis_in abnormally proliferating cells derives_from glial cells, has_symptom seizure, headaches, nausea and vomiting, memory loss, changes to personality, mood or concentration; and localized neurological problems. (DO)
Synonyms:exact_synonym: brain glioblastoma;   glioblastoma multiforme of brain
 xref: EFO:0000515;   EFO:0006545;   NCI:C4642
For additional species annotation, visit the Alliance of Genome Resources.

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brain glioblastoma multiforme term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EEF2 eukaryotic translation elongation factor 2 ISO protein:increased expression:brain (human) RGD PMID:24589652 RGD:153297816 NCBI chr 6:3,733,056...3,742,526
Ensembl chr 6:3,732,425...3,742,826 		JBrowse link
G NCAM1 neural cell adhesion molecule 1 disease_progression ISO RGD PMID:20219118 RGD:40924672 NCBI chr 1:104,332,622...104,647,258 JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling ISO human, rat, and/or mouse glioma cells in a mouse model RGD PMID:30790292 RGD:150573813 NCBI chr 9:95,532,228...95,660,594
Ensembl chr 9:95,532,242...95,657,290 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15342
    disease of cellular proliferation 7211
      cancer 5273
        cell type cancer 3622
          high grade glioma 685
            brain glioma 26
              brain glioblastoma multiforme 3
Path 2
Term Annotations click to browse term
  disease 15342
    disease of cellular proliferation 7211
      Neoplasms by Site 6685
        Nervous System Neoplasms 1558
          Central Nervous System Neoplasms 1389
            Brain Neoplasms 1343
              Supratentorial Neoplasms 476
                supratentorial cancer 476
                  cerebrum cancer 447
                    malignant astrocytoma 443
                      glioblastoma 164
                        brain glioblastoma multiforme 3
paths to the root