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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:scleritis
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Accession:DOID:13452 term browser browse the term
Definition:Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
Synonyms:exact_synonym: Episcleritides;   Episcleritis;   Necrotizing Scleritides;   Necrotizing Scleritis;   Scleritides
 primary_id: MESH:D015423;   RDO:0006864
 xref: GARD:12911;   ICD10CM:H15.0;   ICD9CM:379.00;   NCI:C119046
For additional species annotation, visit the Alliance of Genome Resources.


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scleritis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor ISO RGD PMID:23177360 RGD:7394776 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    sensory system disease 7022
      eye disease 3492
        scleral disease 2
          scleritis 1
            anterior scleritis + 0
            panophthalmitis 0
            posterior scleritis 0
            scleroperikeratitis 0
Path 2
Term Annotations click to browse term
  disease 18976
    disease of anatomical entity 18260
      nervous system disease 14116
        Neurologic Manifestations 10102
          sensory system disease 7022
            eye disease 3492
              scleral disease 2
                scleritis 1
                  anterior scleritis + 0
                  panophthalmitis 0
                  posterior scleritis 0
                  scleroperikeratitis 0
paths to the root