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ONTOLOGY REPORT - ANNOTATIONS


Term:WLL-vs
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Accession:CHEBI:91210 term browser browse the term
Definition:A dipeptide that is L-tryptophyl-L-leucinamide in which the N-terminal amino group has been converted to the corresponding (morpholin-4-yl)acetamide and in which one of the hydrogens attached to the nitrogen of the C-terminal amide has been replaced by a (1E)-5-methyl-1-(methylsulfonyl)hex-1-en-3-yl group. It is a selective proteasome inhibitor.
Synonyms:exact_synonym: N-(morpholin-4-ylacetyl)-L-tryptophyl-N-[(1E,3S)-5-methyl-1-(methylsulfonyl)hex-1-en-3-yl]-L-leucinamide
 related_synonym: Formula=C31H47N5O6S;   InChI=1S/C31H47N5O6S/c1-21(2)16-24(10-15-43(5,40)41)33-30(38)27(17-22(3)4)35-31(39)28(34-29(37)20-36-11-13-42-14-12-36)18-23-19-32-26-9-7-6-8-25(23)26/h6-10,15,19,21-22,24,27-28,32H,11-14,16-18,20H2,1-5H3,(H,33,38)(H,34,37)(H,35,39)/b15-10+/t24-,27+,28+/m1/s1;   InChIKey=DKBAFRHAWTVKAD-ODGLJRBPSA-N;   SMILES=C(\\[C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC=1C2=CC=CC=C2NC1)NC(=O)CN3CCOCC3)=O)=O)=C/S(C)(=O)=O
 xref: PMID:26863983


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  CHEBI ontology 225
    role 225
      application 192
        pharmaceutical 189
          drug 189
            proteasome inhibitor 0
              WLL-vs 0
Path 2
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  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      carbon group element atom 207
                        carbon atom 206
                          organic molecular entity 206
                            organic group 154
                              organic divalent group 153
                                organodiyl group 153
                                  carbonyl group 153
                                    carbonyl compound 153
                                      carboxylic acid 114
                                        carboacyl group 48
                                          univalent carboacyl group 48
                                            carbamoyl group 45
                                              carboxamide 45
                                                peptide 19
                                                  oligopeptide 15
                                                    dipeptide 9
                                                      Trp-Leu 0
                                                        WLL-vs 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.