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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:palonosetron
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Accession:CHEBI:85161 term browser browse the term
Definition:An organic heterotricyclic compound that is an antiemetic used (as its hydrochloride salt) in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.
Synonyms:exact_synonym: (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one
 related_synonym: 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one;   Formula=C19H24N2O;   InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1;   InChIKey=CPZBLNMUGSZIPR-NVXWUHKLSA-N;   SMILES=O=C1N(C[C@H]2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2;   palonosetronum
 xref: CAS:135729-61-2;   DrugBank:DB00377;   Drug_Central:2046;   HMDB:HMDB0014521;   KEGG:D07175;   LINCS:LSM-5266
 xref_mesh: MESH:C083418
 xref: PMID:23653153;   PMID:24129597;   PMID:24154700;   PMID:24280811;   PMID:24590374;   PMID:24604014;   PMID:24935579;   PMID:24947121;   PMID:25037960;   PMID:25063271;   PMID:25179689;   PMID:25360998;   PMID:25435944;   PMID:25533447;   Wikipedia:Palonosetron
 cyclic_relationship: is_conjugate_base_of CHEBI:85163


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palonosetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO palonosetron results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        pharmaceutical 19556
          drug 19556
            antiemetic 5372
              palonosetron 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      carboacyl group 17728
                                        univalent carboacyl group 17728
                                          carbamoyl group 17548
                                            carboxamide 17580
                                              lactam 8393
                                                delta-lactam 1208
                                                  palonosetron 1
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