Term: | itraconazole |
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Accession: | CHEBI:6076
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Definition: | An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis. |
Synonyms: | exact_synonym: | 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one |
| related_synonym: | Formula=C35H38Cl2N8O4; InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1; InChIKey=VHVPQPYKVGDNFY-ZPGVKDDISA-N; Itrizole (TN); Oriconazole; SMILES=CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(OC[C@H]3CO[C@@](Cn4cncn4)(O3)c3ccc(Cl)cc3Cl)cc2)c1=O; Sporanox (TN) |
| xref: | CAS:84625-61-6; DrugBank:DB01167; KEGG:D00350 |
| xref_mesh: | MESH:D017964 |
| xref: | PMID:11219548; PMID:11403818; PMID:11422002; PMID:15521894; PMID:19025521; PMID:20400651; PMID:25326091; Patent:EP6711; Patent:US4267179; VSDB:1853; Wikipedia:Itraconazole |
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