Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Hedgehog signaling pathway inhibitor
go back to main search page
Accession:CHEBI:140921 term browser browse the term
Definition:Any pathway inhibitor that inhibits the Hedgehog signalling pathway.
Synonyms:related_synonym: Hedgehog pathway inhibitor;   Hedgehog pathway inhibitors;   Hedgehog signaling pathway inhibitors
 xref: Wikipedia:Hedgehog_pathway_inhibitors


show annotations for term's descendants           Sort by:
3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpc1 glypican 1 decreases degradation ISO 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one results in decreased degradation of GPC1 protein CTD PMID:21642435 NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047 		JBrowse link
itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Itraconazole results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects activity
decreases activity
multiple interactions
affects transport		 ISO Itraconazole affects the activity of ABCB1 protein
Itraconazole results in decreased activity of ABCB1 protein
Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Itraconazole promotes the reaction [ABCB1 gene SNP affects the susceptibility to fexofenadine]
ABCB1 protein affects the transport of Itraconazole		 CTD PMID:15905803 PMID:15964336 PMID:15969931 PMID:16084853 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acvr1c activin A receptor type 1C increases expression ISO Itraconazole results in increased expression of ACVR1C mRNA CTD PMID:31099283 NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein] CTD PMID:17923278 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Amdhd1 amidohydrolase domain containing 1 decreases expression ISO Itraconazole results in decreased expression of AMDHD1 mRNA CTD PMID:31099283 NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156 		JBrowse link
G Ar androgen receptor multiple interactions ISO Itraconazole binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bicc1 BicC family RNA binding protein 1 decreases expression ISO Itraconazole results in decreased expression of BICC1 mRNA CTD PMID:31099283 NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cpn2 carboxypeptidase N subunit 2 decreases expression ISO Itraconazole results in decreased expression of CPN2 mRNA CTD PMID:31099283 NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Itraconazole results in increased expression of CXCL1 mRNA CTD PMID:31099283 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO Itraconazole binds to and results in decreased activity of CYP11B1 protein CTD PMID:31982514 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO Itraconazole binds to and results in decreased activity of CYP11B2 protein CTD PMID:31982514 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity		 ISO Dactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Itraconazole results in increased expression of and results in increased activity of CYP1A1 protein
Itraconazole results in increased expression of CYP1A1 mRNA; Itraconazole results in increased expression of CYP1A1 protein
Itraconazole results in decreased activity of CYP1A1 protein		 CTD PMID:17283379 PMID:28390928 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases activity ISO
EXP		 Itraconazole results in decreased activity of CYP24A1 protein CTD PMID:15328084 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
affects activity
decreases activity
affects metabolic processing
increases metabolic processing
decreases expression		 ISO Itraconazole binds to and results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased hydroxylation of Itraconazole
Itraconazole affects the activity of CYP3A4 protein
Itraconazole results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Itraconazole
CYP3A4 protein results in increased metabolism of Itraconazole
Itraconazole results in decreased expression of CYP3A4 mRNA; Itraconazole results in decreased expression of CYP3A4 protein		 CTD PMID:15328084 PMID:15383492 PMID:15447735 PMID:15684493 PMID:15784650 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
decreases response to substance
multiple interactions		 ISO Itraconazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Itraconazole
CYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]		 CTD PMID:16989930 PMID:18694951 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Dclre1c DNA cross-link repair 1C increases expression ISO Itraconazole results in increased expression of DCLRE1C mRNA CTD PMID:31099283 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Itraconazole results in increased expression of DDIT3 mRNA CTD PMID:31099283 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dtna dystrobrevin, alpha decreases expression ISO Itraconazole results in decreased expression of DTNA mRNA CTD PMID:31099283 NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261 		JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 decreases expression ISO Itraconazole results in decreased expression of ENPP3 mRNA CTD PMID:31099283 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041 		JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 decreases expression ISO Itraconazole results in decreased expression of ESCO2 mRNA CTD PMID:31099283 NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Itraconazole results in decreased expression of ESRRA mRNA CTD PMID:31099283 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO Itraconazole results in increased expression of FABP5 mRNA CTD PMID:31099283 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Itraconazole results in increased expression of FOSL1 mRNA CTD PMID:31099283 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 decreases expression ISO Itraconazole results in decreased expression of GFPT1 mRNA CTD PMID:31099283 NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression ISO Itraconazole results in decreased expression of GJB1 mRNA CTD PMID:31099283 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO
EXP		 Itraconazole analog results in decreased expression of GLI1 mRNA; Itraconazole results in decreased expression of GLI1 mRNA CTD PMID:21936514 PMID:33905526 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Itraconazole results in increased expression of GOT1 protein CTD PMID:31099283 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Itraconazole results in decreased expression of GPR6 mRNA CTD PMID:31099283 NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Itraconazole results in increased expression of GPT protein CTD PMID:31099283 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Itraconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Itraconazole results in decreased expression of GULP1 mRNA CTD PMID:31099283 NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005 		JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO Itraconazole results in increased expression of HMGA2 mRNA CTD PMID:31099283 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Itraconazole results in increased expression of HMGCS1 mRNA CTD PMID:31099283 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Itraconazole results in decreased expression of HMGCS2 mRNA CTD PMID:31099283 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Itraconazole results in decreased activity of HSD11B2 protein CTD PMID:28131847 PMID:29385285 PMID:33387577 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Ihh Indian hedgehog signaling molecule decreases expression EXP Itraconazole results in decreased expression of IHH mRNA CTD PMID:33905526 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Il12b interleukin 12B increases expression ISO Itraconazole results in increased expression of IL12B mRNA CTD PMID:31099283 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
decreases secretion		 ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:11886533 PMID:15284827 PMID:23688403 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
decreases expression		 ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein] CTD PMID:11886533 PMID:15284827 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703 		JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 increases expression ISO Itraconazole results in increased expression of MBD1 mRNA CTD PMID:31099283 NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554 		JBrowse link
G Myt1 myelin transcription factor 1 increases expression ISO Itraconazole results in increased expression of MYT1 mRNA CTD PMID:31099283 NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]] CTD PMID:17998298 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of NQO1 mRNA]
Itraconazole results in increased expression of NQO1 mRNA; Itraconazole results in increased expression of NQO1 protein		 CTD PMID:17923278 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression		 ISO Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Itraconazole promotes the reaction [Rifampin results in increased expression of NR1I2 mRNA]
Itraconazole results in increased expression of NR1I2 mRNA		 CTD PMID:17998298 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Oaz3 ornithine decarboxylase antizyme 3 decreases expression ISO Itraconazole results in decreased expression of OAZ3 mRNA CTD PMID:31099283 NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399 		JBrowse link
G Pnma2 PNMA family member 2 increases expression ISO Itraconazole results in increased expression of PNMA2 mRNA CTD PMID:31099283 NCBI chr15:41,111,942...41,119,649
Ensembl chr15:41,112,009...41,121,427 		JBrowse link
G Ptch1 patched 1 decreases expression EXP Itraconazole results in decreased expression of PTCH1 mRNA CTD PMID:33905526 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO Itraconazole results in decreased expression of RAPGEF4 mRNA CTD PMID:31099283 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Itraconazole results in decreased expression of RGS16 mRNA CTD PMID:31099283 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 increases expression ISO Itraconazole results in increased expression of RPP25 mRNA CTD PMID:31099283 NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732 		JBrowse link
G Sema3e semaphorin 3E increases expression ISO Itraconazole results in increased expression of SEMA3E mRNA CTD PMID:31099283 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229 		JBrowse link
G Slc25a36 solute carrier family 25 member 36 increases expression ISO Itraconazole results in increased expression of SLC25A36 mRNA CTD PMID:31099283 NCBI chr 8:97,659,848...97,693,735
Ensembl chr 8:97,662,127...97,693,703 		JBrowse link
G Smo smoothened, frizzled class receptor decreases expression EXP Itraconazole results in decreased expression of SMO mRNA CTD PMID:33905526 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Itraconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stx8 syntaxin 8 increases expression ISO Itraconazole results in increased expression of STX8 mRNA CTD PMID:31099283 NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993 		JBrowse link
G Sycp3 synaptonemal complex protein 3 increases expression ISO Itraconazole results in increased expression of SYCP3 mRNA CTD PMID:31099283 NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511 		JBrowse link
G Tbc1d9 TBC1 domain family member 9 increases expression ISO Itraconazole results in increased expression of TBC1D9 mRNA CTD PMID:31099283 NCBI chr19:24,842,166...24,951,383
Ensembl chr19:24,842,205...24,943,129 		JBrowse link
G Tmem138 transmembrane protein 138 decreases expression ISO Itraconazole results in decreased expression of TMEM138 mRNA CTD PMID:31099283 NCBI chr 1:207,219,113...207,226,159 JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO Itraconazole results in decreased expression of TMSB4X mRNA CTD PMID:31099283 NCBI chr  X:27,144,666...27,146,667
Ensembl chr  X:27,128,610...27,146,667 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO Itraconazole results in decreased expression of TSPAN8 mRNA CTD PMID:31099283 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356 		JBrowse link
G Zfp451 zinc finger protein 451 increases expression ISO Itraconazole results in increased expression of ZFP451 mRNA CTD PMID:31099283 NCBI chr 9:35,985,441...36,040,991
Ensembl chr 9:35,985,443...36,040,652 		JBrowse link
sonidegib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 decreases expression ISO sonidegib results in decreased expression of GLI1 mRNA CTD PMID:24973920 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression
multiple interactions
decreases response to substance		 ISO sonidegib results in decreased expression of GLI2 mRNA
sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
GLI2 protein results in decreased susceptibility to sonidegib		 CTD PMID:24973920 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation EXP sonidegib results in increased phosphorylation of MTOR protein CTD PMID:31568847 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases response to substance ISO MYCN protein results in decreased susceptibility to sonidegib CTD PMID:24973920 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590 		JBrowse link
G Smo smoothened, frizzled class receptor decreases response to substance ISO SMO protein mutant form results in decreased susceptibility to sonidegib CTD PMID:24973920 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling multiple interactions
decreases response to substance		 ISO sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
SUFU gene mutant form results in decreased susceptibility to sonidegib		 CTD PMID:24973920 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
vismodegib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO HhAntag691 inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; HhAntag691 inhibits the reaction [AGT protein results in increased expression of SHH protein] CTD PMID:31181250 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein] CTD PMID:22087285 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO HhAntag691 inhibits the reaction [nickel monoxide results in decreased expression of BECN1 protein] CTD PMID:34608745 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO HhAntag691 results in increased cleavage of CASP3 protein CTD PMID:22087285 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO HhAntag691 results in decreased expression of CCND1 mRNA CTD PMID:24973920 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO HhAntag691 results in decreased expression of CCND2 mRNA CTD PMID:24973920 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO HhAntag691 results in decreased expression of CDK6 mRNA CTD PMID:24973920 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions		 ISO HhAntag691 results in increased expression of FAS protein
[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]		 CTD PMID:22087285 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions
decreases expression 		ISO [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag691; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]
vismodegib decreases Gli1 protein expression in pituitary adenoma cells
HhAntag691 results in decreased expression of GLI1 mRNA		 CTD
RGD		 PMID:22087285 PMID:24973920 PMID:27585885 PMID:31181250 PMID:31642701 More... RGD:150573695 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions
increases response to substance
decreases expression
decreases response to substance		 ISO [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag691; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI2 protein]
GLI2 gene mutant form results in increased susceptibility to HhAntag691
HhAntag691 results in decreased expression of GLI2 mRNA
GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
GLI2 protein results in decreased susceptibility to HhAntag691		 CTD PMID:22087285 PMID:24973920 PMID:27585885 PMID:31181250 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions ISO HhAntag691 inhibits the reaction [AGT protein results in decreased expression of GLI3 protein] CTD PMID:31181250 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Hhip Hedgehog-interacting protein decreases expression ISO HhAntag691 results in decreased expression of HHIP mRNA CTD PMID:24973920 NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO HhAntag691 inhibits the reaction [nickel monoxide results in decreased lipidation of and results in decreased cleavage of MAP1LC3B protein] CTD PMID:34608745 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases response to substance ISO MYCN protein results in decreased susceptibility to HhAntag691 CTD PMID:24973920 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590 		JBrowse link
G Pax6 paired box 6 increases expression ISO HhAntag691 results in increased expression of PAX6 mRNA CTD PMID:27585885 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions
decreases expression		 ISO [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein] CTD PMID:22087285 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO vismodegib increases protein kinase A protein expression in pituitary adenoma cells RGD PMID:31519191 RGD:150573695 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ptch1 patched 1 decreases expression
multiple interactions		 ISO HhAntag691 results in decreased expression of PTCH1 mRNA
GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]		 CTD PMID:22087285 PMID:24973920 PMID:27585885 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Ptch2 patched 2 decreases expression ISO HhAntag691 results in decreased expression of PTCH2 mRNA CTD PMID:22087285 NCBI chr 5:130,571,956...130,592,506
Ensembl chr 5:130,572,312...130,592,405 		JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression
multiple interactions		 ISO HhAntag691 results in decreased expression of SHH mRNA
GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]
HhAntag691 inhibits the reaction [AGT protein results in increased expression of SHH protein]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]		 CTD PMID:27585885 PMID:31181250 PMID:31642701 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smo smoothened, frizzled class receptor decreases expression
decreases response to substance		 ISO HhAntag691 results in decreased expression of SMO mRNA
SMO protein mutant form results in decreased susceptibility to HhAntag691		 CTD PMID:22087285 PMID:24973920 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO HhAntag691 inhibits the reaction [nickel monoxide results in increased expression of SQSTM1 protein] CTD PMID:34608745 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling decreases response to substance
increases expression
multiple interactions		 ISO SUFU gene mutant form results in decreased susceptibility to HhAntag691
vismodegib increases SUFU protein expression in pituitary adenoma cells
HhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]		 CTD
RGD		 PMID:24973920 PMID:31519191 RGD:150573695 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression
multiple interactions		 ISO HhAntag691 results in increased expression of TNFRSF10A protein
[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]		 CTD PMID:22087285 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        biochemical role 19598
          enzyme inhibitor 18785
            pathway inhibitor 11762
              Hedgehog signaling pathway inhibitor 90
                3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride 1
                GANT61 0
                glasdegib 0
                itraconazole 67
                smoothib 0
                sonidegib + 6
                sonidegib phosphate 0
                vismodegib 24
paths to the root