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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fluoxymesterone
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Accession:CHEBI:5120 term browser browse the term
Definition:An anabolic androgenic steroid that has formula C20H29FO3.
Synonyms:exact_synonym: 9-fluoro-11beta,17beta-dihydroxy-17alpha-methylandrost-4-en-3-one
 related_synonym: 11beta,17beta-Dihydroxy-9alpha-fluoro-17alpha-methyl-4-androster-3-one;   17alpha-Methyl-9alpha-fluoro-11beta-hydroxytesterone;   9-Fluoro-11beta,17beta-dihydroxy-17-methylandrost-4-en-3-one;   9alpha-Fluoro-11beta-hydroxy-17-methyltestosterone;   Formula=C20H29FO3;   InChI=1S/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3/t14-,15-,16-,17-,18-,19-,20-/m0/s1;   InChIKey=YLRFCQOZQXIBAB-RBZZARIASA-N;   SMILES=[H][C@]1(O)C[C@@]2(C)[C@@]([H])(CC[C@]2(C)O)[C@]2([H])CCC3=CC(=O)CC[C@]3(C)[C@@]12F;   Testosterone, 9-fluoro-11beta-hydroxy-17-methyl-;   fluoximesterona;   fluoxymesteronum
 xref: Beilstein:2008796;   CAS:76-43-7;   DrugBank:DB01185;   Drug_Central:1210;   KEGG:D00327;   LIPID_MAPS_instance:LMST02020025
 xref_mesh: MESH:D005474
 xref: Patent:US2813881;   Wikipedia:Fluoxymesterone


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fluoxymesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases activity		 ISO Fluoxymesterone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]; HSD11B2 protein binds to and results in increased metabolism of Fluoxymesterone
Fluoxymesterone results in decreased activity of HSD11B2 protein		 CTD PMID:22273746 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      application 19653
        pharmaceutical 19494
          drug 19494
            antineoplastic agent 17763
              fluoxymesterone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            heteroorganic entity 19484
                              organochalcogen compound 19248
                                organooxygen compound 19165
                                  carbonyl compound 18890
                                    ketone 17186
                                      oxo steroid 10544
                                        3-oxo steroid 9933
                                          3-oxo-Delta(4) steroid 9173
                                            fluoxymesterone 1
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