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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluoxymesterone
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Accession:CHEBI:5120 term browser browse the term
Definition:An anabolic androgenic steroid that has formula C20H29FO3.
Synonyms:exact_synonym: 9-fluoro-11beta,17beta-dihydroxy-17alpha-methylandrost-4-en-3-one
 related_synonym: 11beta,17beta-Dihydroxy-9alpha-fluoro-17alpha-methyl-4-androster-3-one;   17alpha-Methyl-9alpha-fluoro-11beta-hydroxytesterone;   9-Fluoro-11beta,17beta-dihydroxy-17-methylandrost-4-en-3-one;   9alpha-Fluoro-11beta-hydroxy-17-methyltestosterone;   Formula=C20H29FO3;   InChI=1S/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3/t14-,15-,16-,17-,18-,19-,20-/m0/s1;   InChIKey=YLRFCQOZQXIBAB-RBZZARIASA-N;   SMILES=[H][C@]1(O)C[C@@]2(C)[C@@]([H])(CC[C@]2(C)O)[C@]2([H])CCC3=CC(=O)CC[C@]3(C)[C@@]12F;   Testosterone, 9-fluoro-11beta-hydroxy-17-methyl-;   fluoximesterona;   fluoxymesteronum
 xref: Beilstein:2008796;   CAS:76-43-7;   DrugBank:DB01185;   Drug_Central:1210;   KEGG:D00327;   LIPID_MAPS_instance:LMST02020025
 xref_mesh: MESH:D005474
 xref: Patent:US2813881;   Wikipedia:Fluoxymesterone


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fluoxymesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases activity
ISO Fluoxymesterone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]; HSD11B2 protein binds to and results in increased metabolism of Fluoxymesterone
Fluoxymesterone results in decreased activity of HSD11B2 protein
CTD PMID:22273746 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              fluoxymesterone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxo steroid 9275
                                          3-oxo steroid 8805
                                            3-oxo-Delta(4) steroid 7934
                                              fluoxymesterone 1
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