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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:triflupromazine
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Accession:CHEBI:9711 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position.
Synonyms:exact_synonym: N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine
 related_synonym: 10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine;   2-(Trifluoromethyl)promazine;   2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine;   Formula=C18H19F3N2S;   InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3;   InChIKey=XSCGXQMFQXDFCW-UHFFFAOYSA-N;   SMILES=CN(C)CCCN1c2ccccc2Sc2ccc(cc12)C(F)(F)F;   trifluopromazine;   triflupromazina;   triflupromazinum
 xref: CAS:146-54-3;   DrugBank:DB00508;   Drug_Central:2742;   HMDB:HMDB0014650;   KEGG:D00390;   LINCS:LSM-3421
 xref_mesh: MESH:D014273
 xref: PMID:1650428;   PMID:24959397;   Patent:GB813861;   Reaxys:335308;   Wikipedia:Triflupromazine


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triflupromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Triflupromazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        antimicrobial agent 18239
          antiviral agent 11339
            anticoronaviral agent 10035
              triflupromazine 1
                triflupromazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    main group molecular entity 19806
                      s-block molecular entity 19641
                        hydrogen molecular entity 19622
                          hydrides 19150
                            inorganic hydride 18152
                              pnictogen hydride 18164
                                nitrogen hydride 18055
                                  azane 17882
                                    ammonia 17860
                                      organic amino compound 17860
                                        amine 8308
                                          tertiary amine 644
                                            triflupromazine 1
                                              triflupromazine hydrochloride 0
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