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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:parbendazole
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Accession:CHEBI:94267 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (methoxycarbonyl)amino and butyl groups at positions 2 and 5, respectively. It is a potent inhibitor of microtubule assembly and also exhibits anthelminthic activity.
Synonyms:exact_synonym: methyl (5-butyl-1H-benzimidazol-2-yl)carbamate
 related_synonym: 5-butyl-2-(carbomethoxyamino)benzimidazole;   Formula=C13H17N3O2;   Helatac;   Helmatac;   InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17);   InChIKey=YRWLZFXJFBZBEY-UHFFFAOYSA-N;   N-(5-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester;   PBZ;   SK&F 29044;   SKF-29044;   SKF29044;   SMILES=CCCCC1=CC2=C(NC(NC(=O)OC)=N2)C=C1;   methyl 5-butylbenzimidazole-2-carbamate;   parbendazol;   parbendazolum
 xref: CAS:14255-87-9;   HMDB:HMDB0256126;   KEGG:D05365;   LINCS:LSM-4893
 xref_mesh: MESH:C100292
 xref: PDBeChem:H1C;   PMID:1036798;   PMID:1242825;   PMID:1573698;   PMID:22469223;   PMID:26420877;   PMID:31861153;   PMID:3445963;   PMID:3477162;   PMID:35478655;   PMID:35576703;   PMID:35646536;   PMID:3593136;   PMID:3617427;   PMID:37210557;   PMID:37446147;   PMID:38131223;   PMID:38267545;   PMID:3840535;   PMID:4430805;   PMID:4666441;   PMID:4845733;   PMID:5184664;   PMID:5404541;   PMID:5680252;   PMID:5812439;   PMID:6892671;   PMID:6894647;   PMID:6895936;   PMID:817814


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parbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO parbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22307
    role 22292
      application 21907
        pesticide 19005
          nematicide 6519
            antinematodal drug 4706
              parbendazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 22307
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22182
                    p-block element atom 22182
                      carbon group element atom 21984
                        carbon atom 21924
                          organic molecular entity 21924
                            organic molecule 21750
                              organic cyclic compound 21366
                                organic heterocyclic compound 20382
                                  organic heteropolycyclic compound 19675
                                    organic heterobicyclic compound 18253
                                      benzimidazoles 1182
                                        parbendazole 1
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