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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:7-oxolithocholic acid
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Accession:CHEBI:82679 term browser browse the term
Definition:A bile acid that is lithocholic acid carrying an additional oxo substituent at position 7.
Synonyms:exact_synonym: (3alpha,5beta)-3-hydroxy-7-oxocholan-24-oic acid
 related_synonym: 3-alpha-Hydroxy-7-oxo-5-beta-cholan-24-oic acid;   3alpha-Hydroxy-7-oxo-5beta-cholanic acid;   3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid;   7-Ketolithocholic acid;   7-oxo-3alpha-hydroxycholan-24-oic acid;   Formula=C24H38O4;   InChI=1S/C24H38O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-19,22,25H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,22+,23+,24-/m1/s1;   InChIKey=DXOCDBGWDZAYRQ-AURDAFMXSA-N;   Nutriacholic acid;   SMILES=C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CC[C@@H](O)C[C@H]1CC3=O
 xref: CAS:4651-67-6;   HMDB:HMDB0000467;   LIPID_MAPS_instance:LMST04010150
 xref_mesh: MESH:C023020
 xref: PMID:13525374;   PMID:21453287;   PMID:23933573;   PMID:2401860;   PMID:2811609;   PMID:2912152;   PMID:3480039;   PMID:3943698;   PMID:3943699;   PMID:4016150;   PMID:4063074;   PMID:4090568;   PMID:520764;   PMID:6631218;   PMID:7084613;   PMID:7380227;   PMID:7435569;   Reaxys:3222783
 cyclic_relationship: is_conjugate_acid_of CHEBI:78605


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7-oxolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases reduction
multiple interactions		 ISO HSD11B1 protein results in increased reduction of 7-ketolithocholic acid
[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Chenodeoxycholic Acid; [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid		 CTD PMID:21453287 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            protective agent 18187
              geroprotector 17357
                lithocholic acid 267
                  7-oxolithocholic acid 1
                    7-oxotaurolithocholic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic polycyclic compound 17225
                                  steroid 14678
                                    steroid fundamental parent 14474
                                      cholane 1000
                                        cholanoid 1000
                                          cholanic acids 984
                                            cholanic acid 984
                                              5beta-cholanic acid 984
                                                hydroxy-5beta-cholanic acid 984
                                                  bile acid 984
                                                    lithocholic acid 267
                                                      7-oxolithocholic acid 1
                                                        7-oxotaurolithocholic acid 0
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