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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:spirotetramat
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Accession:CHEBI:81975 term browser browse the term
Definition:An azaspiro compound that is methoxycyclohexane which is fused at position 4 to the 5-position of a 1,5-dihydro-2H-pyrrol-2-one that is substituted at positions 3 and 4 by 2,5-dimethylphenyl and (ethoxycarbonyl)oxy groups, respectively (the cis isomer). It is a proinsecticide (via hydrolysis of the ethyl carbonate group to give the corresponding 4-hydroxypyrrol-2-one, 'spirotetramat-enol') and is used for the control of a wide range of sucking insects on fruit and potato crops.
Synonyms:exact_synonym: (5s,8s)-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl carbonate
 related_synonym: Formula=C21H27NO5;   InChI=1S/C21H27NO5/c1-5-26-20(24)27-18-17(16-12-13(2)6-7-14(16)3)19(23)22-21(18)10-8-15(25-4)9-11-21/h6-7,12,15H,5,8-11H2,1-4H3,(H,22,23)/t15-,21+;   InChIKey=CLSVJBIHYWPGQY-GGYDESQDSA-N;   Movento;   SMILES=C1(=C(C=CC(=C1)C)C)C=2C(NC3(C2OC(OCC)=O)CCC(CC3)OC)=O;   Ultor;   cis-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl carbonate;   cis-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethylcarbonate;   ethyl cis-8-methoxy-2-oxo-3-(2,5-xylyl)-1-azaspiro[4.5]dec-3-en-4-yl carbonate
 xref: CAS:203313-25-1;   KEGG:C18807
 xref_mesh: MESH:C570705
 xref: PMID:22160136;   PMID:22531003;   PMID:22872376;   PMID:24772560;   PMID:24835551;   PMID:25281882;   PMID:26081578;   PMID:26304426;   PMID:26383737;   PMID:26449612;   PMID:26743711;   PMID:26898726;   PMID:27083908;   PMID:27788413;   PMID:27857899;   PMID:27917277;   PMID:27989834;   PMID:28139069;   PMID:28334236;   PPDB:1119;   Patent:EP2039248;   Pesticides:spirotetramat;   Reaxys:14441154


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spirotetramat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxo1 forkhead box O1 increases expression ISO spirotetramat results in increased expression of FOXO1 mRNA CTD PMID:27917277 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Vnn1 vanin 1 decreases expression ISO spirotetramat results in decreased expression of VNN1 mRNA CTD PMID:27917277 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        agrochemical 16259
          spirotetramat 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              lactam 8381
                                                gamma-lactam 6642
                                                  spirotetramat 2
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