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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:asenapine
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Accession:CHEBI:71253 term browser browse the term
Definition:A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine. Used as its maleate salt for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.
Synonyms:exact_synonym: rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
 related_synonym: (3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole;   asenapina;   asenapinum;   trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
 xref: CAS:65576-45-6
 xref_mesh: MESH:C522667
 xref: PMID:21474903;   PMID:21557265;   PMID:21628604;   PMID:21755540;   PMID:21875607;   PMID:22156709;   PMID:22182459;   PMID:22198448;   PMID:22198451;   PMID:22332980;   PMID:22344545;   PMID:22362425;   PMID:22454251;   PMID:22494521;   PMID:22700206;   PMID:22726414;   PMID:22745558;   PMID:22849428;   PMID:22868059;   PMID:22877962;   PMID:22896826;   PMID:22900950;   PMID:22936407;   PMID:23095277;   PMID:23121334;   Patent:US2005119248;   Patent:US2006084692;   Patent:US2006229352;   Patent:WO2012038975;   Patent:WO2012040845;   Patent:WO2012123325;   Reaxys:3654823;   Wikipedia:Asenapine
 cyclic_relationship: is_conjugate_base_of CHEBI:71249


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asenapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
decreases expression		 ISO Asenapine results in decreased activity of CYP1A2 protein
Asenapine results in decreased expression of CYP1A2 mRNA		 CTD PMID:32941854 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    chemical entity 19867
      chemical substance 14415
        mixture 13709
          racemate 12111
            asenapine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    main group molecular entity 19806
                      s-block molecular entity 19641
                        hydrogen molecular entity 19622
                          hydrides 19150
                            inorganic hydride 18152
                              pnictogen hydride 18164
                                nitrogen hydride 18055
                                  azane 17882
                                    ammonia 17860
                                      organic amino compound 17860
                                        tertiary amino compound 10153
                                          5-chloro-2-methyl-2,3,3a,12b-tetrahydrodibenzo[2,3:6,7]oxepino[4,5-c]pyrrole 1
                                            (S,S)-asenapine 1
                                              asenapine 1
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