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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:midodrine
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Accession:CHEBI:6933 term browser browse the term
Definition:An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Synonyms:exact_synonym: rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide
 related_synonym: (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide;   1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol;   2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide;   DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid;   Formula=C12H18N2O4;   InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);   InChIKey=PTKSEFOSCHHMPD-UHFFFAOYSA-N;   SMILES=COc1ccc(OC)c(c1)C(O)CNC(=O)CN;   midodrina;   midodrinum
 xref: CAS:42794-76-3;   DrugBank:DB00211;   Drug_Central:1803;   HMDB:HMDB0014356;   KEGG:C07890;   KEGG:D08220;   LINCS:LSM-1815
 xref_mesh: MESH:D008879
 xref: PMID:11096750;   PMID:15273244;   PMID:16676655;   PMID:17901021;   PMID:18410283;   PMID:18840368;   PMID:19522958;   PMID:20376815;   PMID:20844343;   PMID:21343575;   PMID:21801220;   PMID:22436941;   PMID:23051063;   Patent:GB1003659;   Patent:US3340298;   Reaxys:2384653;   Wikipedia:Midodrine
 cyclic_relationship: is_conjugate_base_of CHEBI:73243


show annotations for term's descendants           Sort by:
midodrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Midodrine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Midodrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        pro-agent 11549
          prodrug 11293
            midodrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    main group molecular entity 19806
                      s-block molecular entity 19641
                        hydrogen molecular entity 19622
                          hydrides 19150
                            inorganic hydride 18152
                              pnictogen hydride 18164
                                nitrogen hydride 18055
                                  azane 17882
                                    ammonia 17860
                                      organic amino compound 17860
                                        amino acid 16056
                                          alpha-amino acid 13931
                                            serine family amino acid 5748
                                              glycine 3325
                                                glycine derivative 3319
                                                  glycinamide 647
                                                    midodrine 2
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