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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:corticotropin-releasing hormone
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Accession:CHEBI:65311 term browser browse the term
Definition:A family of peptide hormones derived from a 191-membered prehormone, secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. The first full sequence was discovered in sheep, those in rats and humans differ from the ovine sequence by 7 amino acids.
Synonyms:related_synonym: CRH;   corticotropin-releasing factor
 xref_mesh: MESH:D003346
 xref: PMID:22494987;   PMID:6267699;   Wikipedia:Corticotropin-releasing_hormone


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corticotropin-releasing hormone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr1 corticotropin releasing hormone receptor 1 increases expression
multiple interactions
decreases activity		 ISO Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA
Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]		 CTD PMID:12093084 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22307
    role 22292
      biological role 22291
        molecular messenger 19503
          neurotransmitter 12153
            corticotropin-releasing hormone 1
              corticotropin-releasing hormone (human) 0
              corticotropin-releasing hormone (ovine) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22307
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22182
                    p-block element atom 22182
                      carbon group element atom 21984
                        carbon atom 21924
                          organic molecular entity 21924
                            heteroorganic entity 21565
                              organochalcogen compound 21051
                                organooxygen compound 20899
                                  carbon oxoacid 19649
                                    carboxylic acid 19645
                                      carboacyl group 18314
                                        univalent carboacyl group 18314
                                          carbamoyl group 18135
                                            carboxamide 18135
                                              peptide 11549
                                                polypeptide 330
                                                  corticotropin-releasing hormone 1
                                                    corticotropin-releasing hormone (human) 0
                                                    corticotropin-releasing hormone (ovine) 0
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