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corticotropin-releasing hormone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:corticotropin-releasing hormone
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Accession:CHEBI:65311 term browser browse the term
Definition:A family of peptide hormones derived from a 191-membered prehormone, secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. The first full sequence was discovered in sheep, those in rats and humans differ from the ovine sequence by 7 amino acids.
Synonyms:related_synonym: CRH;   corticotropin-releasing factor
 xref_mesh: MESH:D003346
 xref: PMID:22494987;   PMID:6267699;   Wikipedia:Corticotropin-releasing_hormone

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corticotropin-releasing hormone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr1 corticotropin releasing hormone receptor 1 increases expression
multiple interactions
decreases activity		 ISO Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA
Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]		 CTD PMID:12093084 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22327
    role 22313
      biological role 22312
        molecular messenger 19533
          neurotransmitter 12136
            corticotropin-releasing hormone 1
              corticotropin-releasing hormone (human) 0
              corticotropin-releasing hormone (ovine) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22327
    subatomic particle 22322
      composite particle 22322
        hadron 22322
          baryon 22322
            nucleon 22322
              atomic nucleus 22322
                atom 22322
                  main group element atom 22209
                    p-block element atom 22209
                      carbon group element atom 22015
                        carbon atom 21958
                          organic molecular entity 21958
                            heteroorganic entity 21604
                              organochalcogen compound 21109
                                organooxygen compound 20946
                                  carbon oxoacid 19736
                                    carboxylic acid 19732
                                      carboacyl group 18298
                                        univalent carboacyl group 18298
                                          carbamoyl group 18112
                                            carboxamide 18112
                                              peptide 11549
                                                polypeptide 330
                                                  corticotropin-releasing hormone 1
                                                    corticotropin-releasing hormone (human) 0
                                                    corticotropin-releasing hormone (ovine) 0
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