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cyclazosin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclazosin
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Accession:CHEBI:63937 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of furoic acid with the secondary amino group of 6,7-dimethoxy-2-[(4aR,8aS)-octahydroquinoxalin-1-yl]quinazolin-4-amine.
Synonyms:exact_synonym: [(4aR,8aS)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)octahydroquinoxalin-1(2H)-yl](2-furyl)methanone
 related_synonym: Formula=C23H27N5O4;   InChI=1S/C23H27N5O4/c1-30-19-12-14-15(13-20(19)31-2)25-23(26-21(14)24)28-10-9-27(16-6-3-4-7-17(16)28)22(29)18-8-5-11-32-18/h5,8,11-13,16-17H,3-4,6-7,9-10H2,1-2H3,(H2,24,25,26)/t16-,17+/m0/s1;   InChIKey=XBRXTUGRUXGBPX-DLBZAZTESA-N;   SMILES=[H][C@]12CCCC[C@@]1([H])N(CCN2C(=O)c1ccco1)c1nc(N)c2cc(OC)c(OC)cc2n1;   cis-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)decahydroquinoxaline
 xref: CAS:139953-73-4
 xref_mesh: MESH:C080462
 xref: PMID:11036156;   PMID:11294762;   PMID:14634588;   PMID:15598431;   PMID:16213480;   PMID:17276073;   PMID:18037913;   PMID:18702011;   PMID:8666020;   PMID:8917649;   PMID:9851544;   PMID:9871765;   Reaxys:8020551

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cyclazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1b adrenoceptor alpha 1B multiple interactions EXP cyclazosin binds to and results in decreased activity of ADRA1B protein CTD PMID:15951348 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        pharmacological role 19906
          antagonist 17589
            adenosine receptor antagonist 4101
              adenosine A2A receptor antagonist 3743
                cyclazosin 1
                  cyclazosin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              monocarboxylic acid amide 15949
                                                cyclazosin 1
                                                  cyclazosin hydrochloride 0
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