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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:guanadrel
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Accession:CHEBI:5555 term browser browse the term
Definition:A spiroketal resulting from the formal condensation of the keto group of cyclohexanone with the hydroxy groups of 1-(2,3-dihydroxypropyl)guanidine. A postganglionic adrenergic blocking agent formerly used (generally as the sulfate salt) for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching).
Synonyms:exact_synonym: 1-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)guanidine
 related_synonym: Formula=C10H19N3O2;   InChI=1S/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13);   InChIKey=HPBNRIOWIXYZFK-UHFFFAOYSA-N;   SMILES=NC(=N)NCC1COC2(CCCCC2)O1;   guanadrelum
 xref: CAS:40580-59-4;   DrugBank:DB00226;   Drug_Central:1339;   HMDB:HMDB0014371;   KEGG:C07035;   KEGG:D08029;   PMID:1443127;   PMID:3896742;   PMID:6621504;   PMID:7206175;   PMID:8473492;   Patent:US3547951;   Reaxys:8325419;   Wikipedia:Guanadrel
 cyclic_relationship: is_conjugate_base_of CHEBI:72602


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19893
    role 19863
      application 19707
        pharmaceutical 19542
          drug 19542
            cardiovascular drug 8652
              antihypertensive agent 1948
                guanadrel 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19893
    subatomic particle 19891
      composite particle 19891
        hadron 19891
          baryon 19891
            nucleon 19891
              atomic nucleus 19891
                atom 19891
                  main group element atom 19830
                    p-block element atom 19830
                      carbon group element atom 19771
                        carbon atom 19767
                          organic molecular entity 19767
                            heteroorganic entity 19525
                              organochalcogen compound 19286
                                organooxygen compound 19202
                                  acetal 10744
                                    ketal 6098
                                      cyclic ketal 6032
                                        spiroketal 4432
                                          guanadrel 0
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