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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiroketal
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Accession:CHEBI:72600 term browser browse the term
Definition:A cyclic ketal in which the ketal carbon is the only common atom of two rings.
Synonyms:related_synonym: spiroacetal;   spiroacetals;   spiroketals
 xref: PMID:19262920;   PMID:20024126;   PMID:21076755;   PMID:21604735;   PMID:21860857;   PMID:22421755


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22,23-dihydroavermectin B1a term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; 22,23-dihydroavermectin B(1)a inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; 22,23-dihydroavermectin B(1)a inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
dioscin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein] CTD PMID:27317372 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO
EXP
dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein CTD PMID:24680847 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein] CTD PMID:27317372 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP
ISO
dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein] CTD PMID:24146112 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO
EXP
dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein] CTD PMID:24146112 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP
ISO
dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:24146112 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions ISO
EXP
dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein] CTD PMID:24146112 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions ISO
EXP
dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein] CTD PMID:24146112 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]
dioscin results in decreased expression of AKT1 mRNA
CTD PMID:25111127, PMID:29990575 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 multiple interactions ISO
EXP
dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein] CTD PMID:24146112 NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP
ISO
dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein] CTD PMID:24146112 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression
ISO dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]
dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein
CTD PMID:22334414, PMID:22939915, PMID:29990575 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
dioscin results in increased expression of BAX protein
CTD PMID:22334414, PMID:22939915 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO dioscin results in increased expression of BBC3 mRNA CTD PMID:29990575 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
dioscin results in increased expression of BCL2 protein
dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein
CTD PMID:22334414, PMID:22939915, PMID:24742230, PMID:29990575 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein CTD PMID:22334414, PMID:29990575 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression
ISO [Acetaminophen co-treated with dioscin] results in increased expression of BID protein
dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein
CTD PMID:22334414, PMID:22939915 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO dioscin results in increased expression of BIRC5 mRNA CTD PMID:29990575 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
EXP
ISO
dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]
dioscin results in increased activity of CASP3 protein
CTD PMID:22334414, PMID:24146112, PMID:29990575 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases expression ISO dioscin results in increased expression of CASP7 mRNA CTD PMID:29990575 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity
increases expression
ISO dioscin results in increased activity of CASP8 protein
dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein
CTD PMID:22334414, PMID:29990575 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
EXP
ISO
dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein
CTD PMID:24146112, PMID:29990575 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein CTD PMID:29990575 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO dioscin results in increased expression of CCND1 mRNA CTD PMID:29990575 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein CTD PMID:29990575 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein CTD PMID:29990575 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein CTD PMID:29990575 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO
EXP
dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:24146112 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
ISO dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA]
CTD PMID:24742230 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP
dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:22939915, PMID:24146112 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO
EXP
dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA] CTD PMID:24146112 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO
EXP
dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA] CTD PMID:24146112 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO dioscin results in increased expression of DIABLO mRNA CTD PMID:29990575 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions
ISO dioscin results in increased expression of ESR1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein]
CTD PMID:24742230 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein] CTD PMID:24742230 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fadd Fas associated via death domain increases expression ISO dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein CTD PMID:22334414, PMID:29990575 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein CTD PMID:22334414 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein CTD PMID:22334414, PMID:29990575 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] CTD PMID:27317372 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein] CTD PMID:24146112 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver]
CTD PMID:28082111, PMID:29091898 RGD:15090820 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver]
CTD PMID:28082111, PMID:29091898 RGD:15090820 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP
ISO
dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] CTD PMID:24146112 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver]
CTD PMID:28082111, PMID:29091898 RGD:15090820 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]
dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver]
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]
CTD PMID:24146112, PMID:28082111, PMID:29091898 RGD:15090820 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] CTD PMID:25111127 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Krt18 keratin 18 multiple interactions ISO
EXP
dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein] CTD PMID:22939915, PMID:24146112 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] CTD PMID:24742230 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:24146112, PMID:25111127 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:24146112, PMID:25111127 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO dioscin results in increased expression of MAPK8 mRNA CTD PMID:29990575 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO dioscin results in increased expression of MAPK9 mRNA CTD PMID:29990575 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mdh1 malate dehydrogenase 1 multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein] CTD PMID:22939915 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO dioscin results in decreased expression of MTOR mRNA CTD PMID:29990575 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver]
CTD PMID:28082111, PMID:29091898 RGD:15090820 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation ISO dioscin results in decreased degradation of NFKBIA protein CTD PMID:24680847 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases expression
EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]
dioscin results in increased expression of NR0B2 mRNA
CTD PMID:27317372 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver]
CTD PMID:28082111, PMID:29091898 RGD:15090820 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
ISO
EXP
dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]
dioscin results in increased expression of PARP1 mRNA
CTD PMID:24146112, PMID:29990575 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta decreases expression ISO dioscin results in decreased expression of PIK3CB mRNA CTD PMID:29990575 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pnp purine nucleoside phosphorylase multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein] CTD PMID:22939915 NCBI chr15:27,875,883...27,883,566
Ensembl chr15:27,875,911...27,883,350
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO
dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:24146112 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein] CTD PMID:22939915 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO dioscin results in increased expression of PRKAB1 mRNA CTD PMID:29990575 NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein] CTD PMID:25111127 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] CTD PMID:28082111 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgn regucalcin multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein] CTD PMID:22939915 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO dioscin results in decreased expression of RPS6KB1 mRNA CTD PMID:29990575 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:27317372 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP dioscin results in increased expression of SLCO1A2 mRNA CTD PMID:27317372 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases expression
EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein]
dioscin results in increased expression of SLCO1B2 mRNA
CTD PMID:27317372 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Suox sulfite oxidase multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein] CTD PMID:22939915 NCBI chr 7:3,098,228...3,102,179
Ensembl chr 7:3,098,245...3,102,142
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]
dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver]
dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein
dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
CTD PMID:22334414, PMID:24146112, PMID:28082111, PMID:29990575, PMID:29091898 RGD:15090820 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions
ISO dioscin results in increased expression of TNFRSF11B mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]
CTD PMID:24742230 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein CTD PMID:22334414, PMID:29990575 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO dioscin results in increased expression of TNFRSF25 mRNA CTD PMID:29990575 NCBI chr 5:169,288,419...169,293,137
Ensembl chr 5:169,288,871...169,293,137
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions
ISO dioscin results in decreased expression of TNFSF11 mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA]
CTD PMID:24742230 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein]
dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein
CTD PMID:22334414, PMID:22939915, PMID:24146112, PMID:29990575 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO dioscin results in increased expression of TRADD mRNA CTD PMID:29990575 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO dioscin results in increased expression of TRAF1 protein CTD PMID:22334414 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO dioscin results in increased expression of WEE1 mRNA CTD PMID:29990575 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link
diosgenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
EXP [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC2 mRNA
Diosgenin results in increased expression of ABCC2 mRNA
CTD PMID:16105132 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
EXP Diosgenin results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC3 mRNA
CTD PMID:16105132 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
multiple interactions
EXP
ISO
Diosgenin results in increased expression of ABCG5 mRNA
[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG5 mRNA
Diosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]
CTD PMID:12963437, PMID:15611112, PMID:16105132 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression
multiple interactions
EXP
ISO
Diosgenin results in increased expression of ABCG8 mRNA
[Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG8 mRNA
Diosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]
CTD PMID:12963437, PMID:15611112, PMID:16105132 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] CTD PMID:16331273 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein] CTD PMID:16331273 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]
Diosgenin results in decreased expression of BCL2 protein
CTD PMID:16331273 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions
decreases expression
ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]
Diosgenin results in decreased expression of BCL2A1 protein
CTD PMID:16331273 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO Diosgenin results in decreased expression of BCL2L1 protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]
CTD PMID:16331273 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression
ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]
Diosgenin results in decreased expression of BIRC2 protein
CTD PMID:16331273 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Diosgenin results in decreased expression of CCL2 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]
CTD PMID:26408789 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:16331273 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions
ISO Diosgenin results in decreased expression of CFLAR protein
Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]
CTD PMID:16331273 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO Diosgenin results in decreased expression of CTNNB1 mRNA CTD PMID:26408789 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of CYP7A1 mRNA CTD PMID:12963437 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
ISO Diosgenin inhibits the reaction [Dietary Fats results in decreased expression of ESR2 protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein]
Diosgenin results in increased expression of ESR2 protein
CTD PMID:26408789 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression
multiple interactions
ISO Diosgenin results in decreased expression of FABP4 mRNA
Diosgenin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; rosiglitazone inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]
CTD PMID:26408789 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO Diosgenin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
Diosgenin results in decreased expression of IL6 mRNA
CTD PMID:26408789 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lipc lipase C, hepatic type increases activity EXP Diosgenin results in increased activity of LIPC protein CTD PMID:20149787 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Mest mesoderm specific transcript multiple interactions
decreases expression
ISO Diosgenin inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]
Diosgenin results in decreased expression of MEST mRNA
CTD PMID:26408789 NCBI chr 4:58,052,786...58,063,227
Ensembl chr 4:58,053,041...58,063,138
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression
EXP Diosgenin results in increased activity of MMP2 protein
Diosgenin results in increased expression of MMP2 mRNA
CTD PMID:21814480 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity
ISO
EXP
Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
Diosgenin results in decreased expression of MMP9 mRNA
Diosgenin results in decreased activity of MMP9 protein
CTD PMID:16331273, PMID:21814480 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:16331273 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:16331273 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:16331273 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Diosgenin results in increased activity of NR1I2 protein CTD PMID:15611112 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases response to substance
decreases expression
multiple interactions
ISO Diosgenin results in increased expression of PPARG protein
PPARG protein results in decreased susceptibility to Diosgenin
Diosgenin results in decreased expression of PPARG mRNA
[Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; fulvestrant inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of FABP4 mRNA]; PPARG protein inhibits the reaction [Diosgenin results in decreased expression of PPARG mRNA]
CTD PMID:24001619, PMID:26408789 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:16331273 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein] CTD PMID:16331273 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]] which results in decreased activity of PPARG protein; Diosgenin inhibits the reaction [RXRA protein binds to PPARG protein]; Diosgenin promotes the reaction [RXRA protein binds to ESR2 protein] CTD PMID:26408789 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Diosgenin results in decreased activity of TNF protein
CTD PMID:16331273 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases activity
ISO Diosgenin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]
Diosgenin results in decreased activity of TNFSF11 protein
CTD PMID:16331273 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein] CTD PMID:16331273 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wnt10b Wnt family member 10B decreases expression ISO Diosgenin results in decreased expression of WNT10B mRNA CTD PMID:26408789 NCBI chr 7:140,448,284...140,466,159
Ensembl chr 7:140,448,465...140,454,268
JBrowse link
eprinomectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO eprinomectin results in decreased activity of ABCB1A protein CTD PMID:17134887 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
increases expression
decreases activity
increases export
decreases response to substance
multiple interactions
increases response to substance
affects binding
affects response to substance
ISO ABCB1 gene polymorphism affects the abundance of Ivermectin
Ivermectin results in increased expression of ABCB1A mRNA
Ivermectin results in decreased activity of ABCB1A protein
ABCB1A protein results in increased export of Ivermectin
ABCB1A protein results in decreased susceptibility to Ivermectin
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin results in increased expression of and results in increased stability of ABCB1A mRNA; Ivermectin results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
ABCB1A gene mutant form results in increased susceptibility to Ivermectin; ABCB1A protein mutant form results in increased susceptibility to Ivermectin
Ivermectin results in decreased activity of ABCB1 protein
ABCB1 protein affects the abundance of Ivermectin
Ivermectin inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
Ivermectin binds to ABCB1 protein
ABCB1 gene polymorphism affects the susceptibility to Ivermectin
CTD PMID:8917702, PMID:8949985, PMID:9144452, PMID:17134887, PMID:18633165, PMID:19161460, PMID:20513441, PMID:20595473, PMID:20630055, PMID:22024132, PMID:22834856, PMID:24998875, PMID:25865432 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions
increases expression
ISO [ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin results in increased expression of and results in increased stability of ABCB1B mRNA
Ivermectin results in increased expression of ABCB1B mRNA
CTD PMID:19161460, PMID:22024132, PMID:24998875 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity
ISO Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
Ivermectin results in decreased activity of ABCC1 protein
CTD PMID:25865432 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Ivermectin results in increased expression of ABCC2 mRNA CTD PMID:24998875 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Ivermectin results in increased expression of ABCG2 mRNA CTD PMID:24998875 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaca acetyl-CoA carboxylase alpha affects expression
decreases expression
multiple interactions
ISO Ivermectin affects the expression of ACACA mRNA
Ivermectin results in decreased expression of ACACA mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACACA protein]
Ivermectin inhibits the reaction [Palmitic Acid results in decreased phosphorylation of ACACA protein]
CTD PMID:30738135, PMID:31199990 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA CTD PMID:16861626 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
JBrowse link
G Adm adrenomedullin decreases expression ISO Ivermectin results in decreased expression of ADM mRNA CTD PMID:28942281 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases expression ISO Ivermectin results in increased expression of ALDH1L2 mRNA CTD PMID:28942281 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression ISO Ivermectin results in increased expression of ANGPTL6 mRNA CTD PMID:28942281 NCBI chr 8:21,895,523...21,902,002
Ensembl chr 8:21,895,524...21,901,829
JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of ARL4C mRNA CTD PMID:16861626 NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Ivermectin results in increased expression of ATF4 mRNA CTD PMID:28942281 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO Ivermectin results in increased expression of ATF5 mRNA CTD PMID:28942281 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Ivermectin results in increased expression of ATF6 mRNA CTD PMID:28942281 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA CTD PMID:16861626 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ivermectin results in increased expression of BAX protein CTD PMID:28811376 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Ivermectin inhibits the reaction [geranylgeranic acid results in increased expression of BBC3 mRNA] CTD PMID:24658405 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO Ivermectin results in decreased expression of BNIP3 mRNA CTD PMID:28942281 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Camp cathelicidin antimicrobial peptide decreases expression ISO Ivermectin results in decreased expression of CAMP mRNA; Ivermectin results in decreased expression of CAMP protein CTD PMID:28653460 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Ivermectin results in decreased activity of CAT protein
Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]
CTD PMID:28880400 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCL3 protein CTD PMID:16861626 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CCR7 mRNA CTD PMID:16861626 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA CTD PMID:16861626 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610
JBrowse link
G Cd36 CD36 molecule affects expression ISO Ivermectin affects the expression of CD36 mRNA CTD PMID:31199990 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Ivermectin results in increased expression of CDH1 CTD PMID:26078298 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Ivermectin results in increased expression of CDKN1A protein CTD PMID:28811376 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Ivermectin results in increased expression of CDKN1B protein CTD PMID:28811376 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression
multiple interactions
ISO Ivermectin affects the expression of CEBPA mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of CEBPA mRNA]
CTD PMID:31199990 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 increases expression ISO Ivermectin results in increased expression of COX6A2 mRNA; Ivermectin results in increased expression of COX6A2 protein CTD PMID:28942281 NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression
multiple interactions
ISO Ivermectin affects the expression of CPT1A mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]
CTD PMID:30738135, PMID:31199990 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crp C-reactive protein increases expression ISO Ivermectin results in increased expression of CRP protein CTD PMID:8555762 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CTSL mRNA CTD PMID:16861626 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
ISO Ivermectin results in decreased activity of CYP1A1 protein
Ivermectin results in increased expression of CYP1A1 mRNA
CTD PMID:18420780, PMID:24998875 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Ivermectin results in increased expression of CYP1A2 mRNA CTD PMID:24998875 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ivermectin results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity
increases expression
ISO Ivermectin results in decreased activity of CYP2B10 protein
Ivermectin results in increased expression of CYP2B10 mRNA
CTD PMID:18420780, PMID:24998875 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Ivermectin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Ivermectin results in decreased activity of CYP2D6 protein
Ivermectin results in decreased activity of CYP2D22 protein
CTD PMID:11124226, PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Ivermectin results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
affects expression
multiple interactions
ISO Ivermectin results in increased expression of DDIT3 mRNA
Ivermectin affects the expression of DDIT3 mRNA
Ivermectin promotes the reaction [Palmitic Acid results in increased expression of DDIT3 protein]
CTD PMID:28942281, PMID:30738135, PMID:31199990 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA CTD PMID:16861626 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA CTD PMID:16861626 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Ivermectin results in increased expression of EDEM1 mRNA CTD PMID:28942281 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression ISO Ivermectin results in decreased expression of EGLN3 mRNA CTD PMID:28942281 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Ivermectin results in increased expression of ESR1 CTD PMID:26078298 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression
multiple interactions
ISO Ivermectin affects the expression of FABP4 mRNA
Rosiglitazone affects the reaction [Ivermectin affects the expression of FABP4 mRNA]
CTD PMID:31199990 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fasn fatty acid synthase affects expression ISO Ivermectin affects the expression of FASN mRNA CTD PMID:31199990 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Ivermectin results in increased expression of GDF15 mRNA CTD PMID:28942281 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA CTD PMID:16861626 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Glra1 glycine receptor, alpha 1 increases activity
multiple interactions
affects activity
ISO Ivermectin results in increased activity of GLRA1 protein mutant form
Ivermectin affects the reaction [Glycine affects the activity of GLRA1 protein mutant form]
Ivermectin affects the activity of GLRA1 protein mutant form
CTD PMID:25231486, PMID:27958714 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Glra3 glycine receptor, alpha 3 affects expression ISO Ivermectin affects the expression of GLRA3 mRNA CTD PMID:31199990 NCBI chr16:37,676,959...37,908,221
Ensembl chr16:37,676,962...38,063,821
JBrowse link
G Glrb glycine receptor, beta affects expression ISO Ivermectin affects the expression of GLRB mRNA CTD PMID:31199990 NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547
JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of GPR183 mRNA CTD PMID:16861626 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA CTD PMID:16861626 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AB1 mRNA CTD PMID:16861626 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
EXP Ivermectin results in increased expression of HSPA1A mRNA
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA]
CTD PMID:28880400 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA4 mRNA CTD PMID:16861626 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Ivermectin results in increased expression of HSPA5 protein CTD PMID:30738135 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA8 mRNA CTD PMID:16861626 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO Ivermectin results in increased expression of HSPA9 mRNA CTD PMID:28942281 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPD1 mRNA
Ivermectin results in increased expression of HSPD1 mRNA
CTD PMID:16861626, PMID:28942281 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPE1 mRNA CTD PMID:16861626 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA CTD PMID:16861626 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression
multiple interactions
EXP Ivermectin results in increased expression of IGFBP3 mRNA
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA]
CTD PMID:28880400 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL10 protein CTD PMID:16861626 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein CTD PMID:16861626 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA CTD PMID:16861626 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO Ivermectin results in increased expression of LONP1 mRNA CTD PMID:28942281 NCBI chr 9:10,428,853...10,441,180
Ensembl chr 9:10,428,853...10,441,177
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of MAP3K8 mRNA CTD PMID:16861626 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:19168156 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:19168156 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein] CTD PMID:19168156 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mxd1 max dimerization protein 1 multiple interactions ISO Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 4:118,451,752...118,472,150
Ensembl chr 4:118,449,882...118,472,179
JBrowse link
G Myh4 myosin heavy chain 4 multiple interactions EXP Ivermectin inhibits the reaction [Potassium Chloride affects the localization of MYH4 protein] CTD PMID:29293066 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Ivermectin results in decreased expression of NANOG mRNA; Ivermectin results in decreased expression of NANOG protein CTD PMID:29257278 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases expression ISO Ivermectin results in decreased expression of NDRG1 mRNA CTD PMID:28942281 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:19168156 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Ivermectin results in decreased expression of NQO1 mRNA; Ivermectin results in decreased expression of NQO1 protein CTD PMID:22021338 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression
affects expression
ISO Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
Ivermectin results in increased expression of NR1H4 mRNA
Ivermectin affects the expression of NR1H4 mRNA
CTD PMID:27773686, PMID:30738135, PMID:31199990 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ivermectin results in increased expression of NUPR1 mRNA CTD PMID:28942281 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions
increases activity
ISO Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
Ivermectin results in increased activity of P2RX4 protein
CTD PMID:19560503, PMID:21638035, PMID:30545933 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Ivermectin results in increased expression of PARP1 protein modified form CTD PMID:28811376 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pfkl phosphofructokinase, liver type decreases expression ISO Ivermectin results in decreased expression of PFKL mRNA CTD PMID:28942281 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Ivermectin results in decreased expression of POU5F1 mRNA; Ivermectin results in decreased expression of POU5F1 protein CTD PMID:29257278 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO Ivermectin results in decreased expression of PPARA mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of PPARA mRNA]
CTD PMID:30738135 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions
ISO Ivermectin affects the expression of PPARG mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of PPARG mRNA]
CTD PMID:31199990 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPID mRNA CTD PMID:16861626 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685
JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA CTD PMID:16861626 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ptges3 prostaglandin E synthase 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA CTD PMID:16861626 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:19168156 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rpp14 ribonuclease P/MRP subunit p14 increases expression ISO Ivermectin results in increased expression of RPP14 mRNA CTD PMID:28942281 NCBI chr15:18,625,963...18,636,157
Ensembl chr15:18,625,964...18,632,536
JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Ivermectin results in decreased expression of SERPINE1 mRNA CTD PMID:28942281 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions ISO Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of SKAP2 mRNA CTD PMID:16861626 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Ivermectin results in decreased expression of SLC2A1 mRNA CTD PMID:28942281 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects expression ISO Ivermectin affects the expression of SLC2A4 mRNA CTD PMID:31199990 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Ivermectin results in decreased expression of SOX2 mRNA; Ivermectin results in decreased expression of SOX2 protein CTD PMID:29257278 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G St13 ST13, Hsp70 interacting protein multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ST13 mRNA CTD PMID:16861626 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Tcp1 t-complex 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of TCP1 mRNA CTD PMID:16861626 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tfrc transferrin receptor decreases expression ISO Ivermectin results in decreased expression of TFRC mRNA CTD PMID:28942281 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA CTD PMID:16861626 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Ivermectin results in decreased expression of TLR2 protein CTD PMID:28653460 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO Ivermectin results in decreased expression of TLR4 mRNA CTD PMID:28653460 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Ivermectin results in decreased expression of TNF mRNA CTD PMID:28653460 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Ivermectin inhibits the reaction [geranylgeranic acid affects the localization of TP53 protein mutant form] CTD PMID:24658405 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Ivermectin results in increased expression of TRIB3 mRNA CTD PMID:28942281 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TSC22D1 mRNA CTD PMID:16861626 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
milbemycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
decreases expression
ISO moxidectin results in decreased activity of ABCB1A protein
moxidectin results in decreased expression of ABCB1 protein
CTD PMID:17134887, PMID:21458446 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases export
multiple interactions
ISO ABCG2 protein results in increased export of moxidectin
tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of moxidectin]
CTD PMID:19428349 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; moxidectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; moxidectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666, PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
monensin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha multiple interactions ISO Monensin inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Monensin results in increased expression of BNIP3 protein CTD PMID:30718715 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP3 protein] CTD PMID:20799912 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP7 protein] CTD PMID:20799912 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Il6 interleukin 6 decreases secretion ISO Monensin results in decreased secretion of IL6 protein CTD PMID:11216681 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Monensin results in increased cleavage of PARP1 protein CTD PMID:30718715 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]] CTD PMID:29908239 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 decreases expression
increases expression
multiple interactions
ISO Monensin results in decreased expression of TRPM2 protein alternative form
Monensin results in increased expression of TRPM2 protein alternative form
Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form]
CTD PMID:20799912 NCBI chr20:11,434,062...11,482,880
Ensembl chr20:11,436,267...11,482,051
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases response to substance ISO ZEB1 protein results in increased susceptibility to Monensin CTD PMID:30718715 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
oligomycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6v1h ATPase H+ transporting V1 subunit H multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA CTD PMID:28366621 NCBI chr 5:14,262,352...14,367,898
Ensembl chr 5:14,262,349...14,367,898
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO oligomycin A inhibits the reaction [bisphenol A results in increased expression of BCL2 protein] CTD PMID:24909818 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO oligomycin A inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein] CTD PMID:24909818 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO oligomycin A inhibits the reaction [bisphenol A results in increased expression of CCNB1 protein] CTD PMID:24909818 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [bisphenol A co-treated with oligomycin A] results in decreased expression of CCND1 protein CTD PMID:24909818 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [bisphenol A co-treated with oligomycin A] results in decreased expression of CCNE1 protein CTD PMID:24909818 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd14 CD14 molecule increases expression ISO oligomycin A results in increased expression of CD14 protein CTD PMID:26036281 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Fut4 fucosyltransferase 4 increases expression ISO oligomycin A results in increased expression of FUT4 protein CTD PMID:26036281 NCBI chr 8:13,258,768...13,262,729
Ensembl chr 8:13,258,768...13,262,729
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA CTD PMID:28366621 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA]; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein] CTD PMID:28366621 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] results in increased expression of SQSTM1 mRNA] CTD PMID:28366621 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tfeb transcription factor EB multiple interactions ISO [oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]] CTD PMID:28366621 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
oligomycin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO oligomycin B results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
Salinomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot13 acyl-CoA thioesterase 13 decreases expression ISO salinomycin results in decreased expression of ACOT13 mRNA CTD PMID:19682730 NCBI chr17:42,241,141...42,253,611
Ensembl chr17:42,241,159...42,253,649
JBrowse link
G Actg1 actin, gamma 1 decreases expression ISO salinomycin results in decreased expression of ACTG1 mRNA CTD PMID:19682730 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Adam12 ADAM metallopeptidase domain 12 decreases expression ISO salinomycin results in decreased expression of ADAM12 mRNA CTD PMID:19682730 NCBI chr 1:205,951,840...206,286,294
Ensembl chr 1:205,956,342...206,282,575
JBrowse link
G Aebp1 AE binding protein 1 decreases expression ISO salinomycin results in decreased expression of AEBP1 mRNA CTD PMID:19682730 NCBI chr14:86,101,253...86,111,323
Ensembl chr14:86,101,277...86,111,306
JBrowse link
G Agps alkylglycerone phosphate synthase decreases expression ISO salinomycin results in decreased expression of AGPS mRNA CTD PMID:19682730 NCBI chr 3:62,648,352...62,749,250
Ensembl chr 3:62,648,447...62,749,153
JBrowse link
G Aida axin interactor, dorsalization associated decreases expression ISO salinomycin results in decreased expression of AIDA mRNA CTD PMID:19682730 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 decreases expression ISO salinomycin results in decreased expression of AIMP2 mRNA CTD PMID:19682730 NCBI chr12:12,738,784...12,748,345
Ensembl chr12:12,738,812...12,748,345
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO salinomycin results in decreased expression of ALDH1 protein; salinomycin results in decreased expression of ALDH1A1 mRNA CTD PMID:25499043, PMID:30273566 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Alg2 ALG2, alpha-1,3/1,6-mannosyltransferase decreases expression ISO salinomycin results in decreased expression of ALG2 mRNA CTD PMID:19682730 NCBI chr 5:63,187,466...63,192,025
Ensembl chr 5:63,187,468...63,192,025
JBrowse link
G Alkbh1 alkB homolog 1, histone H2A dioxygenase decreases expression ISO salinomycin results in decreased expression of ALKBH1 mRNA CTD PMID:19682730 NCBI chr 6:111,456,096...111,476,829
Ensembl chr 6:111,456,187...111,477,090
JBrowse link
G Ammecr1 AMMECR nuclear protein 1 decreases expression ISO salinomycin results in decreased expression of AMMECR1 mRNA CTD PMID:19682730 NCBI chr  X:114,129,829...114,233,013
Ensembl chr  X:114,131,898...114,232,939
JBrowse link
G Ankrd13c ankyrin repeat domain 13C decreases expression ISO salinomycin results in decreased expression of ANKRD13C mRNA CTD PMID:19682730 NCBI chr 2:264,785,379...264,833,283
Ensembl chr 2:264,786,242...264,833,283
JBrowse link
G Anxa5 annexin A5 decreases expression ISO salinomycin results in decreased expression of ANXA5 mRNA CTD PMID:19682730 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Ar androgen receptor decreases expression ISO salinomycin results in decreased expression of AR mRNA; salinomycin results in decreased expression of AR protein CTD PMID:22215106 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 decreases expression ISO salinomycin results in decreased expression of ARAP1 mRNA CTD PMID:19682730 NCBI chr 1:166,459,062...166,525,200
Ensembl chr 1:166,478,005...166,525,255
JBrowse link
G Arf3 ADP-ribosylation factor 3 decreases expression ISO salinomycin results in decreased expression of ARF3 mRNA CTD PMID:19682730 NCBI chr 7:140,412,463...140,438,751
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 decreases expression ISO salinomycin results in decreased expression of ARPC5 mRNA CTD PMID:19682730 NCBI chr13:70,174,970...70,183,879
Ensembl chr13:70,174,936...70,183,879
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO salinomycin results in increased expression of ATF3 mRNA CTD PMID:22215106 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase decreases expression ISO salinomycin results in decreased expression of ATIC mRNA CTD PMID:19682730 NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
JBrowse link
G Atp13a3 ATPase 13A3 decreases expression ISO salinomycin results in decreased expression of ATP13A3 mRNA CTD PMID:19682730 NCBI chr11:73,936,750...73,963,852
Ensembl chr11:73,936,750...73,963,852
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 decreases expression ISO salinomycin results in decreased expression of ATP1B3 mRNA CTD PMID:19682730 NCBI chr 8:104,190,032...104,221,342
Ensembl chr 8:104,190,032...104,221,342
JBrowse link
G Atxn3 ataxin 3 decreases expression ISO salinomycin results in decreased expression of ATXN3 mRNA CTD PMID:19682730 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461
JBrowse link
G Bag6 BAG cochaperone 6 decreases expression ISO salinomycin results in decreased expression of BAG6 mRNA CTD PMID:19682730 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO salinomycin results in decreased expression of BIRC5 protein CTD PMID:30273566 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Cald1 caldesmon 1 decreases expression ISO salinomycin results in decreased expression of CALD1 mRNA CTD PMID:19682730 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Casp3 caspase 3 increases cleavage ISO salinomycin results in increased cleavage of CASP3 protein CTD PMID:30273566 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 decreases expression ISO salinomycin results in decreased expression of CASP8 mRNA CTD PMID:19682730 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage ISO salinomycin results in increased cleavage of CASP9 protein CTD PMID:30273566 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccdc43 coiled-coil domain containing 43 decreases expression ISO salinomycin results in decreased expression of CCDC43 mRNA CTD PMID:19682730 NCBI chr10:90,644,993...90,658,241
Ensembl chr10:90,644,995...90,657,185
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO salinomycin results in decreased expression of CCL2 mRNA CTD PMID:19682730 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO salinomycin results in decreased expression of CCND2 mRNA CTD PMID:19682730 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccny cyclin Y decreases expression ISO salinomycin results in decreased expression of CCNY mRNA CTD PMID:19682730 NCBI chr17:62,332,537...62,462,644
Ensembl chr17:62,332,537...62,462,644
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO salinomycin results in decreased expression of CD44 protein CTD PMID:30273566 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdc123 cell division cycle 123 decreases expression ISO salinomycin results in decreased expression of CDC123 mRNA CTD PMID:19682730 NCBI chr17:76,410,629...76,454,275
Ensembl chr17:76,410,585...76,454,282
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO salinomycin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:26896736, PMID:30273566 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO salinomycin inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30273566 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cep350 centrosomal protein 350 decreases expression ISO salinomycin results in decreased expression of CEP350 mRNA CTD PMID:19682730 NCBI chr13:73,499,715...73,637,707
Ensembl chr13:73,499,229...73,638,073
JBrowse link
G Clec11a C-type lectin domain containing 11A decreases expression ISO salinomycin results in decreased expression of CLEC11A mRNA CTD PMID:19682730 NCBI chr 1:100,290,374...100,293,515
Ensembl chr 1:100,289,295...100,293,558
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO salinomycin results in decreased expression of CLIC1 mRNA CTD PMID:19682730 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Cltc clathrin heavy chain decreases expression ISO salinomycin results in decreased expression of CLTC mRNA CTD PMID:19682730 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Cnih4 cornichon family AMPA receptor auxiliary protein 4 decreases expression ISO salinomycin results in decreased expression of CNIH4 mRNA CTD PMID:19682730 NCBI chr13:99,469,382...99,490,693
Ensembl chr13:99,473,044...99,489,263
JBrowse link
G Cnot4 CCR4-NOT transcription complex, subunit 4 decreases expression ISO salinomycin results in decreased expression of CNOT4 mRNA CTD PMID:19682730 NCBI chr 4:62,561,443...62,663,225
Ensembl chr 4:62,561,444...62,663,200
JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO salinomycin results in decreased expression of COA7 mRNA CTD PMID:19682730 NCBI chr 5:127,925,726...127,936,516
Ensembl chr 5:127,925,726...127,936,509
JBrowse link
G Copb2 COPI coat complex subunit beta 2 decreases expression ISO salinomycin results in decreased expression of COPB2 mRNA CTD PMID:19682730 NCBI chr 8:106,582,339...106,603,763 JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression ISO salinomycin results in decreased expression of CSNK2A1 mRNA CTD PMID:19682730 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Cstf1 cleavage stimulation factor subunit 1 decreases expression ISO salinomycin results in decreased expression of CSTF1 mRNA CTD PMID:19682730 NCBI chr 3:170,380,413...170,392,162
Ensembl chr 3:170,380,719...170,392,160
JBrowse link
G Ctbs chitobiase decreases expression ISO salinomycin results in decreased expression of CTBS mRNA CTD PMID:19682730 NCBI chr 2:252,305,874...252,320,387
Ensembl chr 2:252,305,874...252,320,387
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of CTNNB1 mRNA] CTD PMID:26896736 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO salinomycin results in decreased activity of CYP2D6 protein CTD PMID:26282489 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dbr1 debranching RNA lariats 1 decreases expression ISO salinomycin results in decreased expression of DBR1 mRNA CTD PMID:19682730 NCBI chr 8:107,826,690...107,838,186
Ensembl chr 8:107,826,424...107,838,339
JBrowse link
G Dcaf7 DDB1 and CUL4 associated factor 7 decreases expression ISO salinomycin results in decreased expression of DCAF7 mRNA CTD PMID:19682730 NCBI chr10:94,231,585...94,254,046
Ensembl chr10:94,231,585...94,254,046
JBrowse link
G Dcbld1 discoidin, CUB and LCCL domain containing 1 decreases expression ISO salinomycin results in decreased expression of DCBLD1 mRNA CTD PMID:19682730 NCBI chr20:33,359,062...33,455,161
Ensembl chr20:33,359,196...33,453,766
JBrowse link
G Dcn decorin decreases expression ISO salinomycin results in decreased expression of DCN mRNA CTD PMID:19682730 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Dcun1d4 defective in cullin neddylation 1 domain containing 4 decreases expression ISO salinomycin results in decreased expression of DCUN1D4 mRNA CTD PMID:19682730 NCBI chr14:37,210,721...37,294,517
Ensembl chr14:37,210,721...37,294,472
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO salinomycin results in increased expression of DDIT3 mRNA CTD PMID:22215106 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO salinomycin results in increased expression of DDIT4 mRNA CTD PMID:22215106 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Desi2 desumoylating isopeptidase 2 decreases expression ISO salinomycin results in decreased expression of DESI2 mRNA CTD PMID:19682730 NCBI chr13:96,111,800...96,156,693
Ensembl chr13:96,111,800...96,154,685
JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 decreases expression ISO salinomycin results in decreased expression of DNAJC13 mRNA CTD PMID:19682730 NCBI chr 8:112,697,907...112,830,445
Ensembl chr 8:112,698,348...112,807,598
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO salinomycin results in decreased expression of DNMT3A mRNA CTD PMID:19682730 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dpf2 double PHD fingers 2 decreases expression ISO salinomycin results in decreased expression of DPF2 mRNA CTD PMID:19682730 NCBI chr 1:221,253,764...221,269,043
Ensembl chr 1:221,253,747...221,269,042
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression ISO salinomycin results in decreased expression of DPYSL3 mRNA CTD PMID:19682730 NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097
JBrowse link
G Dvl3 dishevelled segment polarity protein 3 decreases expression ISO salinomycin results in decreased expression of DVL3 mRNA CTD PMID:19682730 NCBI chr11:84,051,177...84,068,479
Ensembl chr11:84,051,078...84,068,302
JBrowse link
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 decreases expression ISO salinomycin results in decreased expression of EIF4E2 mRNA CTD PMID:19682730 NCBI chr 9:94,310,476...94,325,445
Ensembl chr 9:94,307,852...94,336,831
JBrowse link
G Elp4 elongator acetyltransferase complex subunit 4 decreases expression ISO salinomycin results in decreased expression of ELP4 mRNA CTD PMID:19682730 NCBI chr 3:95,733,810...95,954,987 JBrowse link
G Emp3 epithelial membrane protein 3 decreases expression ISO salinomycin results in decreased expression of EMP3 mRNA CTD PMID:19682730 NCBI chr 1:101,900,731...101,903,948
Ensembl chr 1:101,900,733...101,903,910
JBrowse link
G Eng endoglin decreases expression ISO salinomycin results in decreased expression of ENG protein CTD PMID:30273566 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Erg ETS transcription factor ERG decreases expression ISO salinomycin results in decreased expression of ERG mRNA CTD PMID:22215106 NCBI chr11:35,645,317...35,749,637
Ensembl chr11:35,646,116...35,749,594
JBrowse link
G Etaa1 ETAA1 activator of ATR kinase decreases expression ISO salinomycin results in decreased expression of ETAA1 mRNA CTD PMID:19682730 NCBI chr14:102,290,655...102,293,674
Ensembl chr14:102,290,418...102,293,677
JBrowse link
G Ext1 exostosin glycosyltransferase 1 decreases expression ISO salinomycin results in decreased expression of EXT1 mRNA CTD PMID:19682730 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Fam160b1 family with sequence similarity 160, member B1 decreases expression ISO salinomycin results in decreased expression of FAM160B1 mRNA CTD PMID:19682730 NCBI chr 1:278,198,181...278,224,365
Ensembl chr 1:278,198,179...278,221,686
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO salinomycin results in decreased expression of FGFR1 mRNA CTD PMID:19682730 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fsd1l fibronectin type III and SPRY domain containing 1-like decreases expression ISO salinomycin results in decreased expression of FSD1L mRNA CTD PMID:19682730 NCBI chr 5:70,441,075...70,517,131
Ensembl chr 5:70,441,123...70,511,659
JBrowse link
G Ftl1 ferritin light chain 1 decreases expression ISO salinomycin results in decreased expression of FTL mRNA CTD PMID:19682730 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase decreases expression ISO salinomycin results in decreased expression of FYN mRNA CTD PMID:19682730 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression ISO salinomycin results in decreased expression of FZD2 mRNA CTD PMID:19682730 NCBI chr10:90,550,147...90,552,057
Ensembl chr10:90,550,147...90,552,057
JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO salinomycin results in decreased expression of GAP43 mRNA CTD PMID:19682730 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression ISO salinomycin results in decreased expression of GAPDH mRNA CTD PMID:19682730 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gas6 growth arrest specific 6 decreases expression ISO salinomycin results in decreased expression of GAS6 mRNA CTD PMID:19682730 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Ghr growth hormone receptor decreases expression ISO salinomycin results in decreased expression of GHR mRNA CTD PMID:19682730 NCBI chr 2:53,149,225...53,413,954
Ensembl chr 2:53,150,370...53,413,638
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO salinomycin results in decreased expression of GLI1 mRNA; salinomycin results in decreased expression of GLI1 protein CTD PMID:25499043, PMID:30273566 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gnpda1 glucosamine-6-phosphate deaminase 1 decreases expression ISO salinomycin results in decreased expression of GNPDA1 mRNA CTD PMID:19682730 NCBI chr18:31,479,117...31,489,154
Ensembl chr18:31,479,117...31,487,671
JBrowse link
G Gorab golgin, RAB6-interacting decreases expression ISO salinomycin results in decreased expression of GORAB mRNA CTD PMID:19682730 NCBI chr13:81,682,207...81,698,827
Ensembl chr13:81,682,018...81,698,833
JBrowse link
G Gpc4 glypican 4 decreases expression ISO salinomycin results in decreased expression of GPC4 mRNA CTD PMID:19682730 NCBI chr  X:139,354,325...139,464,876
Ensembl chr  X:139,354,155...139,464,798
JBrowse link
G Gpnmb glycoprotein nmb decreases expression ISO salinomycin results in decreased expression of GPNMB mRNA CTD PMID:19682730 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A decreases expression ISO salinomycin results in decreased expression of GPRC5A mRNA CTD PMID:19682730 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO salinomycin results in decreased expression of GSK3B mRNA CTD PMID:19682730 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtf3c3 general transcription factor IIIC subunit 3 decreases expression ISO salinomycin results in decreased expression of GTF3C3 mRNA CTD PMID:19682730 NCBI chr 9:60,999,159...61,033,612
Ensembl chr 9:60,969,061...61,033,580
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [salinomycin results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO salinomycin results in decreased expression of HIF1A mRNA CTD PMID:19682730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 decreases expression ISO salinomycin results in decreased expression of HS2ST1 mRNA CTD PMID:19682730 NCBI chr 2:250,467,428...250,600,517
Ensembl chr 2:250,467,429...250,600,517
JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase decreases expression ISO salinomycin results in decreased expression of ICMT mRNA CTD PMID:19682730 NCBI chr 5:169,475,270...169,482,031
Ensembl chr 5:169,475,270...169,482,030
JBrowse link
G Igf2r insulin-like growth factor 2 receptor decreases expression ISO salinomycin results in decreased expression of IGF2R mRNA CTD PMID:19682730 NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 decreases expression ISO salinomycin results in decreased expression of IGFBP4 mRNA CTD PMID:19682730 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 decreases expression ISO salinomycin results in decreased expression of IGFBP7 mRNA CTD PMID:19682730 NCBI chr14:33,010,300...33,070,193
Ensembl chr14:33,010,300...33,070,190
JBrowse link
G Ints2 integrator complex subunit 2 decreases expression ISO salinomycin results in decreased expression of INTS2 mRNA CTD PMID:19682730 NCBI chr10:73,632,805...73,690,952
Ensembl chr10:73,634,255...73,690,887
JBrowse link
G Ints8 integrator complex subunit 8 decreases expression ISO salinomycin results in decreased expression of INTS8 mRNA CTD PMID:19682730 NCBI chr 5:24,446,002...24,493,819
Ensembl chr 5:24,445,886...24,493,670
JBrowse link
G Irf9 interferon regulatory factor 9 decreases expression ISO salinomycin results in decreased expression of IRF9 mRNA CTD PMID:19682730 NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
JBrowse link
G Kdelr2 KDEL endoplasmic reticulum protein retention receptor 2 decreases expression ISO salinomycin results in decreased expression of KDELR2 mRNA CTD PMID:19682730 NCBI chr12:13,192,452...13,210,758
Ensembl chr12:13,192,453...13,210,758
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 decreases expression ISO salinomycin results in decreased expression of KDELR3 mRNA CTD PMID:19682730 NCBI chr 7:120,749,680...120,760,163
Ensembl chr 7:120,749,752...120,760,160
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression ISO salinomycin results in increased expression of KLF6 mRNA CTD PMID:22215106 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Klhl20 kelch-like family member 20 decreases expression ISO salinomycin results in decreased expression of KLHL20 mRNA CTD PMID:19682730 NCBI chr13:78,912,361...78,957,226
Ensembl chr13:78,912,361...78,957,212
JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator decreases expression ISO salinomycin results in decreased expression of LARP1 mRNA CTD PMID:19682730 NCBI chr10:43,435,738...43,501,186
Ensembl chr10:43,446,526...43,498,066
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO salinomycin results in decreased expression of LDHA mRNA CTD PMID:19682730 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Lmbr1 limb development membrane protein 1 decreases expression ISO salinomycin results in decreased expression of LMBR1 mRNA CTD PMID:19682730 NCBI chr 4:2,116,094...2,274,111
Ensembl chr 4:2,116,094...2,201,749
JBrowse link
G Lpin2 lipin 2 decreases expression ISO salinomycin results in decreased expression of LPIN2 mRNA CTD PMID:19682730 NCBI chr 9:119,517,101...119,591,533
Ensembl chr 9:119,517,101...119,591,533
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein] CTD PMID:30796972 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO salinomycin results in decreased phosphorylation of MAPK1 protein CTD PMID:28395993 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression ISO salinomycin results in decreased expression of MAPK14 mRNA CTD PMID:19682730 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO salinomycin results in decreased phosphorylation of MAPK3 protein CTD PMID:28395993 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 decreases expression ISO salinomycin results in decreased expression of MARS1 mRNA CTD PMID:19682730 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO salinomycin results in decreased expression of MMP10 mRNA CTD PMID:19682730 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO salinomycin results in decreased expression of MMP14 mRNA CTD PMID:19682730 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases secretion
ISO salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]
salinomycin results in decreased secretion of MMP2 protein
CTD PMID:26896736, PMID:28395993, PMID:30273566 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO salinomycin results in decreased secretion of MMP9 protein CTD PMID:28395993 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt2A metallothionein 2A decreases expression ISO salinomycin results in decreased expression of MT2A mRNA CTD PMID:19682730 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtrex Mtr4 exosome RNA helicase decreases expression ISO salinomycin results in decreased expression of MTREX mRNA CTD PMID:19682730 NCBI chr 2:44,726,716...44,787,013
Ensembl chr 2:44,717,781...44,786,963
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO salinomycin results in decreased expression of MYC mRNA CTD PMID:22215106 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myo10 myosin X decreases expression ISO salinomycin results in decreased expression of MYO10 mRNA CTD PMID:19682730 NCBI chr 2:77,868,398...78,072,443
Ensembl chr 2:77,868,412...78,071,309
JBrowse link
G Nat10 N-acetyltransferase 10 decreases expression ISO salinomycin results in decreased expression of NAT10 mRNA CTD PMID:19682730 NCBI chr 3:93,658,119...93,698,136
Ensembl chr 3:93,658,117...93,698,136
JBrowse link
G Nid1 nidogen 1 decreases expression ISO salinomycin results in decreased expression of NID1 mRNA CTD PMID:19682730 NCBI chr17:90,553,161...90,627,133
Ensembl chr17:90,553,394...90,627,101
JBrowse link
G Nid2 nidogen 2 decreases expression ISO salinomycin results in decreased expression of NID2 mRNA CTD PMID:19682730 NCBI chr15:4,893,999...4,951,893
Ensembl chr15:4,894,213...4,951,917
JBrowse link
G Nol8 nucleolar protein 8 decreases expression ISO salinomycin results in decreased expression of NOL8 mRNA CTD PMID:19682730 NCBI chr17:14,565,794...14,589,154
Ensembl chr17:14,565,794...14,589,154
Ensembl chr17:14,565,794...14,589,154
JBrowse link
G Notch3 notch receptor 3 decreases expression ISO salinomycin results in decreased expression of NOTCH3 mRNA CTD PMID:19682730 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression ISO salinomycin results in decreased expression of NSF mRNA CTD PMID:19682730 NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082
JBrowse link
G Nuak2 NUAK family kinase 2 decreases expression ISO salinomycin results in decreased expression of NUAK2 mRNA CTD PMID:19682730 NCBI chr13:49,092,306...49,109,055
Ensembl chr13:49,092,306...49,109,050
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO salinomycin results in decreased expression of NUCKS1 mRNA CTD PMID:19682730 NCBI chr13:48,679,726...48,709,663
Ensembl chr13:48,679,774...48,705,575
JBrowse link
G Nudt5 nudix hydrolase 5 decreases expression ISO salinomycin results in decreased expression of NUDT5 mRNA CTD PMID:19682730 NCBI chr17:76,387,027...76,410,309
Ensembl chr17:76,387,031...76,410,294
JBrowse link
G Nup37 nucleoporin 37 decreases expression ISO salinomycin results in decreased expression of NUP37 mRNA CTD PMID:19682730 NCBI chr 7:28,715,299...28,750,978
Ensembl chr 7:28,701,690...28,743,326
JBrowse link
G Nup62 nucleoporin 62 decreases expression ISO salinomycin results in decreased expression of NUP62 mRNA CTD PMID:19682730 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 decreases expression ISO salinomycin results in decreased expression of PAK2 mRNA CTD PMID:19682730 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO salinomycin results in increased cleavage of PARP1 protein CTD PMID:30273566 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pde8a phosphodiesterase 8A decreases expression ISO salinomycin results in decreased expression of PDE8A mRNA CTD PMID:19682730 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO salinomycin results in decreased expression of PDGFRB mRNA CTD PMID:19682730 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 decreases expression ISO salinomycin results in decreased expression of PFKFB3 mRNA CTD PMID:19682730 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pgk1 phosphoglycerate kinase 1 decreases expression ISO salinomycin results in decreased expression of PGK1 mRNA CTD PMID:19682730 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases expression ISO salinomycin results in decreased expression of PKD2 mRNA CTD PMID:19682730 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Plaa phospholipase A2, activating protein decreases expression ISO salinomycin results in decreased expression of PLAA mRNA CTD PMID:19682730 NCBI chr 5:113,548,913...113,578,928
Ensembl chr 5:113,548,913...113,578,928
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases expression ISO salinomycin results in decreased expression of PLOD2 mRNA CTD PMID:19682730 NCBI chr 8:99,977,334...100,059,736
Ensembl chr 8:99,977,334...100,059,736
JBrowse link
G Plp2 proteolipid protein 2 decreases expression ISO salinomycin results in decreased expression of PLP2 mRNA CTD PMID:19682730 NCBI chr  X:15,679,254...15,682,653
Ensembl chr  X:15,679,254...15,682,652
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing decreases expression ISO salinomycin results in decreased expression of PNKD mRNA CTD PMID:19682730 NCBI chr 9:81,566,074...81,634,531
Ensembl chr 9:81,566,074...81,634,534
JBrowse link
G Prepl prolyl endopeptidase-like decreases expression ISO salinomycin results in decreased expression of PREPL mRNA CTD PMID:19682730 NCBI chr 6:8,316,861...8,346,293
Ensembl chr 6:8,318,979...8,346,197
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 decreases expression ISO salinomycin results in decreased expression of PSMA5 mRNA CTD PMID:19682730 NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714
JBrowse link
G Psmb7 proteasome 20S subunit beta 7 decreases expression ISO salinomycin results in decreased expression of PSMB7 mRNA CTD PMID:19682730 NCBI chr 3:22,890,072...22,951,718
Ensembl chr 3:22,871,105...22,952,063
JBrowse link
G Psmd8 proteasome 26S subunit, non-ATPase 8 decreases expression ISO salinomycin results in decreased expression of PSMD8 mRNA CTD PMID:19682730 NCBI chr 1:88,116,811...88,123,643
Ensembl chr 1:88,116,812...88,123,643
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO salinomycin results in decreased phosphorylation of PTK2 protein CTD PMID:28395993 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptov1 PTOV1, extended AT-hook containing adaptor protein decreases expression ISO salinomycin results in decreased expression of PTOV1 mRNA CTD PMID:19682730 NCBI chr 1:100,859,346...100,866,917
Ensembl chr 1:100,859,349...100,865,894
JBrowse link
G Rab23 RAB23, member RAS oncogene family decreases expression ISO salinomycin results in decreased expression of RAB23 mRNA CTD PMID:19682730 NCBI chr 9:38,469,784...38,496,185
Ensembl chr 9:38,470,298...38,495,176
JBrowse link
G Rack1 receptor for activated C kinase 1 decreases expression ISO salinomycin results in decreased expression of RACK1 mRNA CTD PMID:19682730 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein decreases expression ISO salinomycin results in decreased expression of RAD23B mRNA CTD PMID:19682730 NCBI chr 5:72,103,704...72,141,701
Ensembl chr 5:72,103,704...72,141,700
JBrowse link
G RGD1308147 similar to expressed sequence AW209491 decreases expression ISO salinomycin results in decreased expression of C7ORF25 mRNA CTD PMID:19682730 NCBI chr17:53,080,629...53,087,335
Ensembl chr17:53,080,638...53,087,274
JBrowse link
G RGD1311345 similar to CG9752-PA decreases expression ISO salinomycin results in decreased expression of C9ORF64 mRNA CTD PMID:19682730 NCBI chr17:6,683,152...6,690,724
Ensembl chr17:6,683,152...6,690,723
JBrowse link
G Rin2 Ras and Rab interactor 2 decreases expression ISO salinomycin results in decreased expression of RIN2 mRNA CTD PMID:19682730 NCBI chr 3:139,871,330...140,087,679
Ensembl chr 3:139,894,331...140,087,678
JBrowse link
G Rnf8 ring finger protein 8 decreases expression ISO salinomycin results in decreased expression of RNF8 mRNA CTD PMID:19682730 NCBI chr20:8,285,380...8,309,858
Ensembl chr20:8,285,296...8,309,908
JBrowse link
G Rybp RING1 and YY1 binding protein decreases expression ISO salinomycin results in decreased expression of RYBP mRNA CTD PMID:19682730 NCBI chr 4:132,689,623...132,740,823
Ensembl chr 4:132,689,531...132,740,938
JBrowse link
G Sdf4 stromal cell derived factor 4 decreases expression ISO salinomycin results in decreased expression of SDF4 mRNA CTD PMID:19682730 NCBI chr 5:173,425,922...173,444,478
Ensembl chr 5:173,425,907...173,444,620
JBrowse link
G Setd5 SET domain containing 5 decreases expression ISO salinomycin results in decreased expression of SETD5 mRNA CTD PMID:19682730 NCBI chr 4:145,017,549...145,095,247
Ensembl chr 4:145,017,608...145,095,245
JBrowse link
G Slc38a9 solute carrier family 38, member 9 decreases expression ISO salinomycin results in decreased expression of SLC38A9 mRNA CTD PMID:19682730 NCBI chr 2:44,512,556...44,592,793
Ensembl chr 2:44,512,895...44,592,053
JBrowse link
G Smg8 SMG8 nonsense mediated mRNA decay factor decreases expression ISO salinomycin results in decreased expression of SMG8 mRNA CTD PMID:19682730 NCBI chr10:74,379,224...74,388,838
Ensembl chr10:74,379,226...74,388,787
JBrowse link
G Smo smoothened, frizzled class receptor decreases expression ISO salinomycin results in decreased expression of SMO mRNA; salinomycin results in decreased expression of SMO protein CTD PMID:25499043, PMID:30273566 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of SNAI1 mRNA]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of SNAI1 protein]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:26896736, PMID:30273566 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snrnp25 small nuclear ribonucleoprotein U11/U12 subunit 25 decreases expression ISO salinomycin results in decreased expression of SNRNP25 mRNA CTD PMID:19682730 NCBI chr10:15,685,999...15,689,338
Ensembl chr10:15,686,008...15,689,325
JBrowse link
G Snx6 sorting nexin 6 decreases expression ISO salinomycin results in decreased expression of SNX6 mRNA CTD PMID:19682730 NCBI chr 6:75,626,927...75,670,172
Ensembl chr 6:75,626,927...75,670,135
JBrowse link
G Spats2l spermatogenesis associated, serine-rich 2-like decreases expression ISO salinomycin results in decreased expression of SPATS2L mRNA CTD PMID:19682730 NCBI chr 9:64,643,223...64,843,963
Ensembl chr 9:64,643,281...64,843,960
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO salinomycin results in decreased expression of SPP1 mRNA CTD PMID:19682730 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Srp54a signal recognition particle 54A decreases expression ISO salinomycin results in decreased expression of SRP54 mRNA CTD PMID:19682730 NCBI chr 6:75,996,629...76,035,768
Ensembl chr 6:75,996,643...76,034,083
JBrowse link
G Ssr1 signal sequence receptor subunit 1 decreases expression ISO salinomycin results in decreased expression of SSR1 mRNA CTD PMID:19682730 NCBI chr17:27,496,369...27,512,781
Ensembl chr17:27,492,220...27,523,912
JBrowse link
G Stam signal transducing adaptor molecule decreases expression ISO salinomycin results in decreased expression of STAM mRNA CTD PMID:19682730 NCBI chr17:81,209,795...81,256,111
Ensembl chr17:81,209,867...81,255,808
JBrowse link
G Stau1 staufen double-stranded RNA binding protein 1 decreases expression ISO salinomycin results in decreased expression of STAU1 mRNA CTD PMID:19682730 NCBI chr 3:163,703,204...163,748,996
Ensembl chr 3:163,703,204...163,748,996
JBrowse link
G Stk39 serine threonine kinase 39 decreases expression ISO salinomycin results in decreased expression of STK39 mRNA CTD PMID:19682730 NCBI chr 3:54,359,449...54,625,702
Ensembl chr 3:54,359,451...54,625,414
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO salinomycin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of CTNNB1 mRNA]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of SNAI1 mRNA]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of SNAI1 protein]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; salinomycin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:26896736, PMID:30273566 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thumpd3 THUMP domain containing 3 decreases expression ISO salinomycin results in decreased expression of THUMPD3 mRNA CTD PMID:19682730 NCBI chr 4:144,985,850...145,010,164
Ensembl chr 4:144,985,880...145,008,831
JBrowse link
G Ticam2 toll-like receptor adaptor molecule 2 decreases expression ISO salinomycin results in decreased expression of TICAM2 mRNA CTD PMID:19682730 NCBI chr18:40,555,106...40,572,569
Ensembl chr18:40,555,106...40,572,241
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO salinomycin results in decreased expression of TIMP3 mRNA CTD PMID:19682730 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tnc tenascin C decreases expression ISO salinomycin results in decreased expression of TNC mRNA CTD PMID:19682730 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO salinomycin results in decreased expression of TUBB3 mRNA CTD PMID:19682730 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO salinomycin results in decreased expression of TUBB mRNA CTD PMID:19682730 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tymp thymidine phosphorylase decreases response to substance
increases expression
multiple interactions
ISO TYMP protein results in decreased susceptibility to salinomycin
salinomycin results in increased expression of TYMP mRNA; salinomycin results in increased expression of TYMP protein
[salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP mRNA]; [salinomycin co-treated with tanespimycin] inhibits the reaction [MAP2K6 protein results in increased expression of TYMP protein]; [tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]]; Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]; salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]; SB 203580 inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; SB 203580 promotes the reaction [[tanespimycin co-treated with salinomycin] results in decreased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]]; tanespimycin inhibits the reaction [salinomycin inhibits the reaction [Cycloheximide results in decreased expression of TYMP protein]]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]
CTD PMID:30796972 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyw5 tRNA-yW synthesizing protein 5 decreases expression ISO salinomycin results in decreased expression of TYW5 mRNA CTD PMID:19682730 NCBI chr 9:64,077,841...64,096,265
Ensembl chr 9:64,077,845...64,096,265
JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) decreases expression ISO salinomycin results in decreased expression of UBE2F mRNA CTD PMID:19682730 NCBI chr 9:98,394,112...98,428,684
Ensembl chr 9:98,398,128...98,428,128
JBrowse link
G Ube2s ubiquitin-conjugating enzyme E2S decreases expression ISO salinomycin results in decreased expression of UBE2S mRNA CTD PMID:19682730 NCBI chr 1:72,580,424...72,584,484
Ensembl chr 1:72,580,424...72,584,482
JBrowse link
G Uhrf1bp1 UHRF1 binding protein 1 decreases expression ISO salinomycin results in decreased expression of UHRF1BP1 mRNA CTD PMID:19682730 NCBI chr20:7,431,235...7,475,515
Ensembl chr20:7,431,355...7,471,900
JBrowse link
G Vim vimentin multiple interactions ISO salinomycin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:26896736 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vopp1 VOPP1 WW domain binding protein decreases expression ISO salinomycin results in decreased expression of VOPP1 mRNA CTD PMID:19682730 NCBI chr 4:88,441,067...88,515,141
Ensembl chr 4:88,441,067...88,515,138
JBrowse link
G Wipf1 WAS/WASL interacting protein family, member 1 decreases expression ISO salinomycin results in decreased expression of WIPF1 mRNA CTD PMID:19682730 NCBI chr 3:60,150,001...60,207,125
Ensembl chr 3:60,150,021...60,166,013
JBrowse link
G Xpnpep1 X-prolyl aminopeptidase 1 decreases expression ISO salinomycin results in decreased expression of XPNPEP1 mRNA CTD PMID:19682730 NCBI chr 1:273,708,217...273,758,247
Ensembl chr 1:273,708,212...273,758,442
JBrowse link
G Xpr1 xenotropic and polytropic retrovirus receptor 1 decreases expression ISO salinomycin results in decreased expression of XPR1 mRNA CTD PMID:19682730 NCBI chr13:72,918,552...73,056,785
Ensembl chr13:72,918,490...73,056,875
JBrowse link
G Yae1 YAE1 maturation factor of ABCE1 decreases expression ISO salinomycin results in decreased expression of YAE1 mRNA CTD PMID:19682730 NCBI chr17:49,610,548...49,617,065
Ensembl chr17:49,610,548...49,617,065
JBrowse link
G Zmat3 zinc finger, matrin type 3 decreases expression ISO salinomycin results in decreased expression of ZMAT3 mRNA CTD PMID:19682730 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator decreases expression ISO salinomycin results in decreased expression of ZYG11B mRNA CTD PMID:19682730 NCBI chr 5:127,844,062...127,878,792
Ensembl chr 5:127,847,129...127,878,792
JBrowse link
spiroxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity ISO spiroxamine results in increased activity of NR3C1 protein CTD PMID:20143881 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        polyatomic entity 19727
          molecule 19554
            cyclic compound 19359
              polycyclic compound 18546
                spiro compound 1300
                  oxaspiro compound 628
                    spiroketal 390
                      19-bromoaplysiatoxin 0
                      22,23-dihydroavermectin B1a + 111
                      22,23-dihydroavermectin B1b + 111
                      26-desglucoavenacoside A 0
                      26-desglucoavenacoside B 0
                      Avermectin B2a aglycone 0
                      NK154183A 0
                      NK154183B 0
                      Salinomycin 189
                      TNP-ATP 0
                      aculeatol E 0
                      amcinonide 0
                      aplysiatoxin 0
                      avenacoside A + 0
                      avenacoside B + 0
                      chrysopine + 0
                      debromoaplysiatoxin 0
                      dioscin 89
                      diosgenin + 108
                      diosgenin 3-O-beta-D-glucoside 0
                      eprinomectin component B1a + 3
                      eprinomectin component B1b + 3
                      guanadrel 0
                      milbemycin + 4
                      monensin A 14
                      mutalomycin 0
                      nocamycin E + 0
                      nocamycin I 0
                      nolinospiroside F 0
                      oligomycin + 14
                      ossamycin 0
                      papulacandin + 0
                      spiroxamine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organooxygen compound 18816
                                  acetal 4568
                                    ketal 2581
                                      cyclic ketal 2471
                                        spiroketal 390
                                          19-bromoaplysiatoxin 0
                                          22,23-dihydroavermectin B1a + 111
                                          22,23-dihydroavermectin B1b + 111
                                          26-desglucoavenacoside A 0
                                          26-desglucoavenacoside B 0
                                          Avermectin B2a aglycone 0
                                          NK154183A 0
                                          NK154183B 0
                                          Salinomycin 189
                                          TNP-ATP 0
                                          aculeatol E 0
                                          amcinonide 0
                                          aplysiatoxin 0
                                          avenacoside A + 0
                                          avenacoside B + 0
                                          chrysopine + 0
                                          debromoaplysiatoxin 0
                                          dioscin 89
                                          diosgenin + 108
                                          diosgenin 3-O-beta-D-glucoside 0
                                          eprinomectin component B1a + 3
                                          eprinomectin component B1b + 3
                                          guanadrel 0
                                          milbemycin + 4
                                          monensin A 14
                                          mutalomycin 0
                                          nocamycin E + 0
                                          nocamycin I 0
                                          nolinospiroside F 0
                                          oligomycin + 14
                                          ossamycin 0
                                          papulacandin + 0
                                          spiroxamine 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.