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diazoxide - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diazoxide
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Accession:CHEBI:4495 term browser browse the term
Definition:A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Synonyms:exact_synonym: 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
 related_synonym: Diazossido;   Eudemine;   Formula=C8H7ClN2O2S;   InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11);   InChIKey=GDLBFKVLRPITMI-UHFFFAOYSA-N;   SMILES=CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1;   diazoxido;   diazoxidum
 alt_id: CHEBI:6046
 xref: CAS:364-98-7;   DrugBank:DB01119;   Drug_Central:854;   HMDB:HMDB0015251;   KEGG:C06949;   KEGG:D00294;   LINCS:LSM-3639
 xref_mesh: MESH:D003981
 xref: PMID:11014217;   PMID:12039709;   PMID:15319354;   PMID:16740260;   PMID:16777075;   PMID:18191077;   PMID:20828743;   PMID:20950601;   PMID:21538163;   PMID:21693179;   PMID:22047130;   PMID:29438107;   Patent:DE723278;   Patent:US2986573;   Patent:US3345365;   Reaxys:523907;   Wikipedia:Diazoxide


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  CHEBI ontology 2
    role 2
      application 2
        pharmaceutical 2
          drug 2
            diuretic 0
              diazoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 2
    subatomic particle 2
      composite particle 2
        hadron 2
          baryon 2
            nucleon 2
              atomic nucleus 2
                atom 2
                  main group element atom 2
                    p-block element atom 2
                      carbon group element atom 2
                        carbon atom 2
                          organic molecular entity 2
                            organic molecule 2
                              organic cyclic compound 2
                                organic heterocyclic compound 2
                                  organonitrogen heterocyclic compound 2
                                    thiazide 0
                                      benzothiadiazine 0
                                        diazoxide 0
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