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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzothiadiazine
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Accession:CHEBI:50265 term browser browse the term
Definition:Heterocyclic compound of a ring with sulfur and two nitrogen atoms fused to a benzene ring. Members inhibit sodium-potassium-chloride symporters and are used as diuretics.
Synonyms:related_synonym: Benzothiadiazines

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bendroflumethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B affects expression ISO Bendroflumethiazide affects the expression of APOB protein CTD PMID:2344503 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Ren renin increases expression ISO Bendroflumethiazide results in increased expression of REN protein CTD PMID:62162 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 increases response to substance EXP SLC12A3 protein results in increased susceptibility to Bendroflumethiazide CTD PMID:18480177 NCBI chr19:11,106,033...11,144,674
Ensembl chr19:11,106,033...11,144,641 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases secretion		 ISO Bendroflumethiazide results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased secretion of Bendroflumethiazide		 CTD PMID:18216144 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
increases secretion		 ISO Bendroflumethiazide results in decreased activity of SLC22A8 protein
SLC22A8 protein results in increased secretion of Bendroflumethiazide		 CTD PMID:18216144 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Bendroflumethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression EXP Bendroflumethiazide results in decreased expression of VEGFC protein CTD PMID:20625077 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576 		JBrowse link
bentazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin increases secretion
multiple interactions		 EXP bentazone results in increased secretion of ALB protein
[bentazone co-treated with Dicamba] results in increased secretion of ALB protein		 CTD PMID:25863332 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
cyclothiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sfrp4 secreted frizzled-related protein 4 affects binding ISO cyclothiazide binds to SFRP4 protein CTD PMID:25019556 NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328 		JBrowse link
diazoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases localization
multiple interactions		 EXP Diazoxide results in decreased localization of AIFM1 protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased localization of AIFM1 protein]		 CTD PMID:21256120 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased phosphorylation of AKT1 protein] CTD PMID:21256120 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:20650802 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:20650802 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 mRNA alternative form]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 protein alternative form]
Diazoxide results in increased expression of BCL2L1 mRNA alternative form; Diazoxide results in increased expression of BCL2L1 protein alternative form		 CTD PMID:15326191 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity		 EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased activity of CASP3 protein] CTD PMID:21256120 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CCND1 mRNA		 CTD PMID:19052819 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CTNNB1 protein		 CTD PMID:19052819 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cycs cytochrome c, somatic decreases secretion
multiple interactions		 EXP Diazoxide results in decreased secretion of CYCS protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased secretion of CYCS protein]		 CTD PMID:21256120 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905 		JBrowse link
G Gcg glucagon multiple interactions ISO Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein] CTD PMID:23200776 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:10464266 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 mRNA]; Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Iapp islet amyloid polypeptide multiple interactions EXP Diazoxide inhibits the reaction [Glucose results in increased expression of IAPP mRNA] CTD PMID:9142872 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Diazoxide results in decreased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il6 interleukin 6 decreases secretion ISO Diazoxide results in decreased secretion of IL6 protein CTD PMID:16612254 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases expression ISO Diazoxide results in decreased expression of KCNJ11 mRNA CTD PMID:23200776 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127 		JBrowse link
G Lep leptin multiple interactions
decreases secretion		 EXP Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]
Diazoxide results in decreased secretion of LEP protein		 CTD PMID:10780946 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Diazoxide inhibits the reaction [Glucose results in increased secretion of NAMPT protein] CTD PMID:23536823 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity		 ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased activity of NFKB1 protein] CTD PMID:15326191 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]]; Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]		 CTD PMID:15795934 PMID:15927086 PMID:16257489 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] CTD PMID:11527545 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA] CTD PMID:11527545 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395 		JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions		 ISO
EXP		 Diazoxide results in decreased secretion of TNF protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]		 CTD PMID:16257489 PMID:16612254 PMID:18700057 PMID:19012619 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Diazoxide results in decreased expression of TP53 mRNA CTD PMID:16426753 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
hydrochlorothiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
increases export		 ISO ABCC4 protein results in increased transport of Hydrochlorothiazide
ABCC4 protein results in increased export of Hydrochlorothiazide		 CTD PMID:17135398 PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Ace angiotensin I converting enzyme increases expression
multiple interactions		 EXP Hydrochlorothiazide results in increased expression of ACE mRNA
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]		 CTD PMID:16326922 PMID:18796534 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA] CTD PMID:16326922 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Hydrochlorothiazide results in decreased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Hydrochlorothiazide results in decreased expression of AGTR1A mRNA CTD PMID:18796534 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Aqp2 aquaporin 2 decreases expression
multiple interactions		 EXP Hydrochlorothiazide results in decreased expression of AQP2 mRNA; Hydrochlorothiazide results in decreased expression of AQP2 protein
Hydrochlorothiazide inhibits the reaction [Lithium results in decreased expression of AQP2 protein]		 CTD PMID:15504936 PMID:17584643 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165 		JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 increases expression EXP Hydrochlorothiazide results in increased expression of ATP6V1B1 protein CTD PMID:17311909 NCBI chr 4:115,417,100...115,435,754
Ensembl chr 4:115,416,580...115,437,206 		JBrowse link
G Avp arginine vasopressin affects secretion ISO Hydrochlorothiazide affects the secretion of AVP protein CTD PMID:6635723 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460 		JBrowse link
G Avpr2 arginine vasopressin receptor 2 decreases expression EXP Hydrochlorothiazide results in decreased expression of AVPR2 mRNA CTD PMID:17584643 NCBI chr  X:156,889,006...156,892,707
Ensembl chr  X:156,889,410...156,891,213 		JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases expression EXP Hydrochlorothiazide results in decreased expression of BDKRB1 mRNA CTD PMID:18796534 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP [Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein
Hydrochlorothiazide results in decreased activity of CAT protein		 CTD PMID:23707192 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Hydrochlorothiazide results in decreased expression of CCL2 mRNA CTD PMID:19627010 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein CTD PMID:11318962 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Cma1 chymase 1 affects expression EXP Hydrochlorothiazide affects the expression of CMA1 mRNA CTD PMID:18796534 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA] CTD PMID:21107329 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB] CTD PMID:21107329 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Hydrochlorothiazide results in increased expression of CYP11B2 mRNA CTD PMID:18796534 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA] CTD PMID:16326922 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions EXP [Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905 		JBrowse link
G Klk1 kallikrein 1 increases expression EXP Hydrochlorothiazide results in increased expression of KLK1 mRNA CTD PMID:18796534 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329 		JBrowse link
G Lepr leptin receptor increases response to substance ISO LEPR mutant form results in increased susceptibility to Hydrochlorothiazide CTD PMID:22949526 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Hydrochlorothiazide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA] CTD PMID:16326922 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein] CTD PMID:16197366 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4] CTD PMID:21107329 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA] CTD PMID:16326922 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Hydrochlorothiazide results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein CTD PMID:11318962 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins] CTD PMID:11703585 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein] CTD PMID:16326922 NCBI chr10:89,166,170...89,168,962
Ensembl chr10:89,166,890...89,168,965 		JBrowse link
G Ramp3 receptor activity modifying protein 3 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein] CTD PMID:16326922 NCBI chr14:86,922,223...86,939,722
Ensembl chr14:86,922,223...86,939,719 		JBrowse link
G Ren renin increases activity
multiple interactions
increases expression		 ISO
EXP		 Hydrochlorothiazide results in increased activity of REN protein
Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]; Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]		 CTD PMID:1930859 PMID:2920503 PMID:11135058 PMID:12569265 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Hydrochlorothiazide affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Hydrochlorothiazide affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Hydrochlorothiazide affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Hydrochlorothiazide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein CTD PMID:11318962 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases expression EXP Hydrochlorothiazide results in increased expression of SLC22A6 protein CTD PMID:12897087 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
trichlormethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a7 solute carrier family 12 member 7 decreases activity ISO Trichlormethiazide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 1:32,086,755...32,167,950
Ensembl chr 1:32,086,755...32,141,036 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Trichlormethiazide inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Trichlormethiazide affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Trichlormethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          nitrogen atom 18620
            nitrogen molecular entity 18620
              organonitrogen compound 18395
                organonitrogen heterocyclic compound 17564
                  thiazide 74
                    benzothiadiazine 74
                      3-fluoro-6a,7,8,9,10,11-hexahydro-6H-azepino[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide 0
                      6-chloro-1,1-dioxo-3-[(prop-2-enylthio)methyl]-3,4-dihydro-2H-1$l^\{6\},2,4-benzothiadiazine-7-sulfonamide 0
                      6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^\{6\},2,4-benzothiadiazine-7-sulfonamide 0
                      7-chloro-3-methyl-3,4-dihydro-2H-1$l^\{6\},2,4-benzothiadiazine 1,1-dioxide 0
                      Benzylhydrochlorothiazide 0
                      Ethiazide 0
                      Methyclothiazide 0
                      Polythiazide 0
                      bemetizide 0
                      bendroflumethiazide + 7
                      bentazone 1
                      benzthiazide 0
                      butizide 0
                      chlorothiazide 0
                      cyclothiazide 1
                      diazoxide 25
                      epitizide 0
                      flumethiazide 0
                      hydrochlorothiazide 40
                      hydroflumethiazide 0
                      mebutizide 0
                      teclothiazide 0
                      trichlormethiazide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      p-block molecular entity 19744
                        carbon group molecular entity 19650
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organonitrogen heterocyclic compound 17564
                                    thiazide 74
                                      benzothiadiazine 74
                                        3-fluoro-6a,7,8,9,10,11-hexahydro-6H-azepino[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide 0
                                        6-chloro-1,1-dioxo-3-[(prop-2-enylthio)methyl]-3,4-dihydro-2H-1$l^\{6\},2,4-benzothiadiazine-7-sulfonamide 0
                                        6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^\{6\},2,4-benzothiadiazine-7-sulfonamide 0
                                        7-chloro-3-methyl-3,4-dihydro-2H-1$l^\{6\},2,4-benzothiadiazine 1,1-dioxide 0
                                        Benzylhydrochlorothiazide 0
                                        Ethiazide 0
                                        Methyclothiazide 0
                                        Polythiazide 0
                                        bemetizide 0
                                        bendroflumethiazide + 7
                                        bentazone 1
                                        benzthiazide 0
                                        butizide 0
                                        chlorothiazide 0
                                        cyclothiazide 1
                                        diazoxide 25
                                        epitizide 0
                                        flumethiazide 0
                                        hydrochlorothiazide 40
                                        hydroflumethiazide 0
                                        mebutizide 0
                                        teclothiazide 0
                                        trichlormethiazide 4
paths to the root