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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiazide
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Accession:CHEBI:50264 term browser browse the term
Definition:Heterocyclic compound with sulfur and nitrogen in the ring.
Synonyms:related_synonym: Thiazides;   tiazidas



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bendroflumethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B affects expression ISO Bendroflumethiazide affects the expression of APOB protein CTD PMID:2344503 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Ren renin increases expression ISO Bendroflumethiazide results in increased expression of REN protein CTD PMID:62162 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc12a3 solute carrier family 12 member 3 increases response to substance EXP SLC12A3 protein results in increased susceptibility to Bendroflumethiazide CTD PMID:18480177 NCBI chr19:10,630,649...10,679,250
Ensembl chr19:10,631,393...10,669,091
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases secretion
ISO Bendroflumethiazide results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
increases secretion
ISO Bendroflumethiazide results in decreased activity of SLC22A8 protein
SLC22A8 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Bendroflumethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression EXP Bendroflumethiazide results in decreased expression of VEGFC protein CTD PMID:20625077 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848
JBrowse link
bentazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin increases secretion
multiple interactions
EXP bentazone results in increased secretion of ALB protein
[bentazone co-treated with Dicamba] results in increased secretion of ALB protein
CTD PMID:25863332 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
cyclothiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sfrp4 secreted frizzled-related protein 4 affects binding ISO cyclothiazide binds to SFRP4 protein CTD PMID:25019556 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736
JBrowse link
diazoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases localization
multiple interactions
EXP Diazoxide results in decreased localization of AIFM1 protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased localization of AIFM1 protein]
CTD PMID:21256120 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased phosphorylation of AKT1 protein] CTD PMID:21256120 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:20650802 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:20650802 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 mRNA alternative form]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 protein alternative form]
Diazoxide results in increased expression of BCL2L1 mRNA alternative form; Diazoxide results in increased expression of BCL2L1 protein alternative form
CTD PMID:15326191 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased activity of CASP3 protein] CTD PMID:21256120 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CCND1 mRNA
CTD PMID:19052819 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CTNNB1 protein
CTD PMID:19052819 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cycs cytochrome c, somatic decreases secretion
multiple interactions
EXP Diazoxide results in decreased secretion of CYCS protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased secretion of CYCS protein]
CTD PMID:21256120 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Gcg glucagon multiple interactions ISO Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein] CTD PMID:23200776 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:10464266 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 mRNA]; Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Iapp islet amyloid polypeptide multiple interactions EXP Diazoxide inhibits the reaction [Glucose results in increased expression of IAPP mRNA] CTD PMID:9142872 NCBI chr 4:175,237,013...175,244,373
Ensembl chr 4:175,237,115...175,242,920
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Diazoxide results in decreased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Diazoxide results in decreased secretion of IL6 protein CTD PMID:16612254 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases expression ISO Diazoxide results in decreased expression of KCNJ11 mRNA CTD PMID:23200776 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Lep leptin multiple interactions
decreases secretion
EXP Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]
Diazoxide results in decreased secretion of LEP protein
CTD PMID:10780946 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Diazoxide inhibits the reaction [Glucose results in increased secretion of NAMPT protein] CTD PMID:23536823 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity
ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased activity of NFKB1 protein] CTD PMID:15326191 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]]; Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]
CTD PMID:15795934 PMID:15927086 PMID:16257489 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] CTD PMID:11527545 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA] CTD PMID:11527545 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO
EXP
Diazoxide results in decreased secretion of TNF protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]
CTD PMID:16257489 PMID:16612254 PMID:18700057 PMID:19012619 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Diazoxide results in decreased expression of TP53 mRNA CTD PMID:16426753 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
hydrochlorothiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
increases export
ISO ABCC4 protein results in increased transport of Hydrochlorothiazide
ABCC4 protein results in increased export of Hydrochlorothiazide
CTD PMID:17135398 PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Ace angiotensin I converting enzyme increases expression
multiple interactions
EXP Hydrochlorothiazide results in increased expression of ACE mRNA
Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]
CTD PMID:16326922 PMID:18796534 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA] CTD PMID:16326922 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Hydrochlorothiazide results in decreased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Hydrochlorothiazide results in decreased expression of AGTR1A mRNA CTD PMID:18796534 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Aqp2 aquaporin 2 decreases expression
multiple interactions
EXP Hydrochlorothiazide results in decreased expression of AQP2 mRNA; Hydrochlorothiazide results in decreased expression of AQP2 protein
Hydrochlorothiazide inhibits the reaction [Lithium results in decreased expression of AQP2 protein]
CTD PMID:15504936 PMID:17584643 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 increases expression EXP Hydrochlorothiazide results in increased expression of ATP6V1B1 protein CTD PMID:17311909 NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
JBrowse link
G Avp arginine vasopressin affects secretion ISO Hydrochlorothiazide affects the secretion of AVP protein CTD PMID:6635723 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr2 arginine vasopressin receptor 2 decreases expression EXP Hydrochlorothiazide results in decreased expression of AVPR2 mRNA CTD PMID:17584643 NCBI chr  X:151,633,501...151,636,000
Ensembl chr  X:151,633,522...151,635,989
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases expression EXP Hydrochlorothiazide results in decreased expression of BDKRB1 mRNA CTD PMID:18796534 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Hydrochlorothiazide co-treated with Fructose] results in decreased activity of CAT protein
Hydrochlorothiazide results in decreased activity of CAT protein
CTD PMID:23707192 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Hydrochlorothiazide results in decreased expression of CCL2 mRNA CTD PMID:19627010 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein CTD PMID:11318962 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cma1 chymase 1 affects expression EXP Hydrochlorothiazide affects the expression of CMA1 mRNA CTD PMID:18796534 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA] CTD PMID:21107329 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB] CTD PMID:21107329 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Hydrochlorothiazide results in increased expression of CYP11B2 mRNA CTD PMID:18796534 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA] CTD PMID:16326922 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions EXP [Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Klk1 kallikrein 1 increases expression EXP Hydrochlorothiazide results in increased expression of KLK1 mRNA CTD PMID:18796534 NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Lepr leptin receptor increases response to substance ISO LEPR mutant form results in increased susceptibility to Hydrochlorothiazide CTD PMID:22949526 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Hydrochlorothiazide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA] CTD PMID:16326922 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein] CTD PMID:16197366 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4] CTD PMID:21107329 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA] CTD PMID:16326922 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Hydrochlorothiazide results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein CTD PMID:11318962 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins] CTD PMID:11703585 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein] CTD PMID:16326922 NCBI chr10:86,187,366...86,190,692 JBrowse link
G Ramp3 receptor activity modifying protein 3 multiple interactions EXP Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein] CTD PMID:16326922 NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902
JBrowse link
G Ren renin increases activity
multiple interactions
increases expression
ISO
EXP
Hydrochlorothiazide results in increased activity of REN protein
Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]; Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]
CTD PMID:1930859 PMID:2920503 PMID:11135058 PMID:12569265 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Hydrochlorothiazide affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:3,403,418...3,479,476 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Hydrochlorothiazide affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Hydrochlorothiazide affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Hydrochlorothiazide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein CTD PMID:11318962 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases expression EXP Hydrochlorothiazide results in increased expression of SLC22A6 protein CTD PMID:12897087 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
trichlormethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a7 solute carrier family 12 member 7 decreases activity ISO Trichlormethiazide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 1:29,472,692...29,554,246
Ensembl chr 1:29,472,692...29,554,302
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Trichlormethiazide inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Trichlormethiazide affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Trichlormethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          nitrogen atom 18774
            nitrogen molecular entity 18774
              organonitrogen compound 18552
                organonitrogen heterocyclic compound 17669
                  thiazide 74
                    benzothiadiazine + 74
                    hydroflumethiazide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    main group molecular entity 19710
                      p-block molecular entity 19710
                        carbon group molecular entity 19631
                          organic molecular entity 19621
                            organic molecule 19562
                              organic cyclic compound 19356
                                organic heterocyclic compound 18596
                                  organonitrogen heterocyclic compound 17669
                                    thiazide 74
                                      benzothiadiazine + 74
                                      hydroflumethiazide 0
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