.
3-methyl-2-oxovaleric acid - Ontology Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-methyl-2-oxovaleric acid
go back to main search page
Accession:CHEBI:35932 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is valeric acid carrying oxo- and methyl substituents at C-2 and C-3, respectively. An alpha-keto acid analogue and metabolite of isoleucine in man, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD).
Synonyms:related_synonym: 2-Oxo-3-methyl-n-valeric acid;   2-Oxo-3-methylpentanoic acid;   2-Oxo-3-methylvalerate;   2-Oxo-3-methylvaleric acid;   2-Oxoisoleucine;   2-oxokolavenic acid;   3-Methyl-2-oxopentanoic acid;   3-ethyl-3-methylpyruvic acid;   Formula=C6H10O3;   InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9);   InChIKey=JVQYSWDUAOAHFM-UHFFFAOYSA-N;   SMILES=CCC(C)C(=O)C(O)=O;   alpha-Oxo-beta-methylvaleric acid;   alpha-keto-beta-methyl-n-valeric acid;   alpha-keto-beta-methylvaleric acid;   alpha-oxo-beta-methyl-n-valeric acid;   ketoisoleucine
 xref: CAS:1460-34-0;   Gmelin:971983;   HMDB:HMDB0000491;   KEGG:C03465
 xref_mesh: MESH:C016211
 xref: PMID:1638756;   PMID:17190852;   PMID:759179;   Reaxys:1098987
 cyclic_relationship: is_conjugate_acid_of CHEBI:28654

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
X

show annotations for term's descendants           Sort by:
3-methyl-2-oxovaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of alpha-keto-beta-methylvaleric acid CTD PMID:20567778 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          metabolite 19554
            eukaryotic metabolite 19381
              plant metabolite 18021
                valeric acid 14538
                  3-methyl-2-oxovaleric acid 1
                    (R)-3-methyl-2-oxovaleric acid 0
                    (S)-3-methyl-2-oxovaleric acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      monocarboxylic acid 18012
                                        fatty acid 16849
                                          saturated fatty acid 16565
                                            straight-chain saturated fatty acid 16099
                                              valeric acid 14538
                                                3-methyl-2-oxovaleric acid 1
                                                  (R)-3-methyl-2-oxovaleric acid 0
                                                  (S)-3-methyl-2-oxovaleric acid 0
paths to the root