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2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene
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Accession:CHEBI:192743 term browser browse the term
Definition:A member of the class of chromenes that is 4H-chromene substituted by amino, cyano, 3-nitrophenyl, and dimethylamino groups at positions 2, 3, 4 and 7, respectively. It exhibits anti-cancer activity.
Synonyms:exact_synonym: 2-amino-7-(dimethylamino)-4-(3-nitrophenyl)-4H-chromene-3-carbonitrile
 related_synonym: 2-amino-7-(dimethylamino)-4-(3-nitrophenyl)-4H-1-benzopyran-3-carbonitrile;   3-NC;   Formula=C18H16N4O3;   InChI=1S/C18H16N4O3/c1-21(2)12-6-7-14-16(9-12)25-18(20)15(10-19)17(14)11-4-3-5-13(8-11)22(23)24/h3-9,17H,20H2,1-2H3;   InChIKey=PNHBABGLCCOXEK-UHFFFAOYSA-N;   SMILES=CN(C)C1=CC=C2C(C3=CC(=CC=C3)[N+]([O-])=O)C(C#N)=C(N)OC2=C1
 xref: PMID:21565459;   PMID:23054714;   PMID:26074734

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2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO 3-NC decreases expression of BIRC3 protein in colorectal carcinoma cells RGD PMID:21565459 RGD:155226872 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
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  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          apoptosis inducer 13666
            2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene 1
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  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  oxacycle 17906
                                    benzopyran 11990
                                      1-benzopyran 11744
                                        chromenes 4440
                                          aminochromene 1
                                            2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene 1
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