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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N(5)-ethyl-L-glutamine
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Accession:CHEBI:17394 term browser browse the term
Definition:A N(5)-alkylglutamine where the alkyl group is ethyl. It has been isolated from green tea.
Synonyms:exact_synonym: (2S)-2-amino-5-(ethylamino)-5-oxopentanoic acid
 related_synonym: Formula=C7H14N2O3;   InChI=1S/C7H14N2O3/c1-2-9-6(10)4-3-5(8)7(11)12/h5H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1;   InChIKey=DATAGRPVKZEWHA-YFKPBYRVSA-N;   L-theanine;   N5-Ethyl-L-glutamine;   SMILES=C(=O)([C@H](CCC(NCC)=O)N)O
 alt_id: CHEBI:12651;   CHEBI:21845;   CHEBI:7397
 xref: CAS:3081-61-6;   HMDB:HMDB0034365;   KEGG:C01047
 xref_mesh: MESH:C026166
 xref: PDBeChem:85G;   PMID:20416364;   PMID:22422488;   PMID:23096008;   PMID:23097345;   PMID:23395732;   PMID:24304633;   Reaxys:1725586;   Wikipedia:L-theanine
 cyclic_relationship: is_tautomer_of CHEBI:58128


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N(5)-ethyl-L-glutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN1 claudin 1 multiple interactions EXP [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA] CTD PMID:37271275 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:37271275
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA] CTD PMID:37271275 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA] CTD PMID:37271275 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228 		JBrowse link
G OCLN occludin multiple interactions EXP [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA] CTD PMID:37271275 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5076
    role 5041
      application 884
        pharmaceutical 737
          drug 737
            protective agent 451
              geroprotector 407
                N(5)-ethyl-L-glutamine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 5076
    subatomic particle 5067
      composite particle 5067
        hadron 5067
          baryon 5067
            nucleon 5044
              atomic nucleus 5067
                atom 5067
                  main group element atom 5037
                    main group molecular entity 5036
                      s-block molecular entity 4967
                        hydrogen molecular entity 4960
                          hydrides 4566
                            inorganic hydride 405
                              pnictogen hydride 401
                                nitrogen hydride 401
                                  azane 393
                                    ammonia 391
                                      organic amino compound 286
                                        amino acid 181
                                          alpha-amino acid 151
                                            L-alpha-amino acid 150
                                              glutamine family amino acid 34
                                                L-glutamic acid 26
                                                  L-glutamic acid derivative 25
                                                    L-glutamine derivative 5
                                                      N(5)-alkyl-L-glutamine 5
                                                        N(5)-ethyl-L-glutamine 5
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