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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:liproxstatin-1
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Accession:CHEBI:173097 term browser browse the term
Definition:An azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis.
Synonyms:exact_synonym: N-(3-chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
 related_synonym: Formula=C19H21ClN4;   InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23);   InChIKey=YAFQFNOUYXZVPZ-UHFFFAOYSA-N;   Lip-1;   N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine;   SMILES=ClC1=CC(CNC2=NC3=CC=CC=C3NC22CCNCC2)=CC=C1;   liproxstatin1
 xref: CAS:950455-15-9;   Chemspider:20387119
 xref_mesh: MESH:C000595890
 xref: PMID:28386601;   PMID:28489094;   PMID:28975372;   PMID:31597407;   PMID:31623831;   PMID:31655003;   PMID:31682397;   PMID:32540488;   PMID:32985488;   PMID:33314758;   PMID:33343803;   PMID:33378529;   PMID:33421025;   PMID:33453994;   PMID:33497529;   PMID:33681224;   PMID:33735625;   PMID:33827043;   PMID:33889074;   PMID:33974796


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liproxstatin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO liproxstatin-1 results in increased expression of KEAP1 protein CTD PMID:37507096 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      chemical role 19420
        antioxidant 16122
          liproxstatin-1 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        secondary amino compound 6829
                                          liproxstatin-1 1
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