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simvastatin hydroxy acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:simvastatin hydroxy acid
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Accession:CHEBI:169041 term browser browse the term
Synonyms:exact_synonym: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
 related_synonym: Formula=C25H40O6;   InChI=1S/C25H40O6/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29)/t15-,16-,18+,19+,20-,21-,23-/m0/s1;   InChIKey=XWLXKKNPFMNSFA-HGQWONQESA-N;   SMILES=O([C@@H]1[C@@]2([C@H]([C@H](C=CC2=C[C@@H](C1)C)C)CC[C@@H](O)C[C@@H](O)CC(O)=O)[H])C(=O)C(CC)(C)C
 xref: CAS:121009-77-6;   Chemspider:58263;   DrugBank:DB14714;   HMDB:HMDB0061047;   KEGG:C21581
 xref_mesh: MESH:C063287
 xref: PDBeChem:SIM


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simvastatin hydroxy acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO simvastatin acid inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid] CTD PMID:15901796 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 multiple interactions
decreases expression
increases uptake
ISO Cyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]; estrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]; Indican promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]; Penicillin G promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]; simvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]
simvastatin acid results in decreased expression of SLCO3A1 protein
CTD PMID:28887287 NCBI chr 1:128,106,232...128,388,043
Ensembl chr 1:128,106,228...128,387,925
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    chemical entity 20854
      group 20798
        inorganic group 20297
          oxo group 19435
            organic oxo compound 19435
              carbonyl compound 19435
                simvastatin hydroxy acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbonyl compound 19435
                                    simvastatin hydroxy acid 2
paths to the root