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PJ34 - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PJ34
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Accession:CHEBI:167900 term browser browse the term
Definition:A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.
Synonyms:related_synonym: 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;   2-(dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one;   Formula=C17H17N3O2;   InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);   InChIKey=UYJZZVDLGDDTCL-UHFFFAOYSA-N;   N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide;   N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide;   N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide;   PJ 34;   SMILES=CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1
 alt_id: CHEBI:44653
 xref: CAS:344458-19-1;   Chemspider:4692;   DrugBank:DB08348;   LINCS:LSM-4937;   PDBeChem:P34;   PMID:11179503;   PMID:11845877;   PMID:15458385;   PMID:16107839;   PMID:17612561;   PMID:18276581;   PMID:18575783;   PMID:18695907;   PMID:19354255;   PMID:19890834;   PMID:21190076;   PMID:21623955;   PMID:22297980;   PMID:22561282;   PMID:22995423;   PMID:23011206;   PMID:23995751;   PMID:24564608;   PMID:24900770;   PMID:25286857;   PMID:25446913;   PMID:25635049;   PMID:25934569;   PMID:26497583;   PMID:27002155;   PMID:27427773;   PMID:28001384;   PMID:28791810;   PMID:29317476;   PMID:29651748;   PMID:30139380;   PMID:30665718;   PMID:30683694;   PMID:31133874;   PMID:31276434;   PMID:31679124;   PMID:31692907;   PMID:32082490;   PMID:32478624;   PMID:32575437;   PMID:32911782;   PMID:33368686;   PMID:33484702;   PMID:33770364
 cyclic_relationship: is_conjugate_base_of CHEBI:167903

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PJ34 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgam integrin subunit alpha M decreases expression EXP PJ34 decreases expression of Itgam mRNA and protein in ischemic brain RGD PMID:23151666 RGD:329902065 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        anti-inflammatory agent 16678
          PJ34 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              secondary carboxamide 1252
                                                PJ34 1
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