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binimetinib - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:binimetinib
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Accession:CHEBI:145371 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.
Synonyms:exact_synonym: 5-(4-bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
 related_synonym: 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide;   5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;   ARRY 162;   ARRY-438162;   Formula=C17H15BrF2N4O3;   InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26);   InChIKey=ACWZRVQXLIRSDF-UHFFFAOYSA-N;   MEK-162;   MEK162;   Mektovi;   N-(2-hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide;   NVP-MEK162;   SMILES=BrC=1C=C(F)C(NC=2C(F)=C3N=CN(C3=CC2C(=O)NOCCO)C)=CC1;   binimetinibum
 xref: CAS:606143-89-9;   DrugBank:DB11967;   KEGG:D10604;   LINCS:LSM-45640
 xref_mesh: MESH:C581313
 xref: PMCID:PMC6012544;   PMID:23414587;   PMID:27071922;   PMID:28152546;   PMID:28412197;   PMID:28587477;   PMID:28851243;   PMID:29785570;   PMID:29946554;   PMID:30117021;   PMID:30635233;   PMID:30648436;   PMID:30652516;   PMID:30956763;   PMID:31050693;   PMID:31129802;   PMID:31213500;   PMID:31312030;   PMID:31395751;   PMID:31436845;   PMID:31437754;   PMID:31631932;   Wikipedia:Binimetinib

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binimetinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with binimetinib] results in decreased activity of CYP1A2 protein CTD PMID:33728909 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
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  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          apoptosis inducer 13666
            binimetinib 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              hydroxamic acid 6342
                                                hydroxamic acid ester 153
                                                  binimetinib 1
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