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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxamic acid ester
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Accession:CHEBI:75606 term browser browse the term
Definition:A carboxamide that is a hydroxamic acid in which the hydrogen of the hydroxy group is replaced by an organyl group.
Synonyms:related_synonym: Formula=CHNO2R2;   RC(O)NHOR';   RCONHOR';   SMILES=[*]C(=O)NO[*];   hydroxamate ester;   hydroxamate esters;   hydroxamic acid esters


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binimetinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with binimetinib] results in decreased activity of CYP1A2 protein CTD PMID:33728909 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
D-cycloserine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egr1 early growth response 1 increases expression EXP Cycloserine results in increased expression of EGR1 protein CTD PMID:19144966 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA] CTD PMID:12464447 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]; Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA] CTD PMID:12464447 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein] CTD PMID:11903061 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein] CTD PMID:11903061 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
PD 0325901 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam19 ADAM metallopeptidase domain 19 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of ADAM19 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ADAM19 mRNA
CTD PMID:25119042 NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105
JBrowse link
G Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ADAMTS6 mRNA CTD PMID:25119042 NCBI chr 2:35,421,483...35,633,305
Ensembl chr 2:35,421,510...35,633,298
JBrowse link
G Akap12 A-kinase anchoring protein 12 decreases expression ISO PD 0325901 results in decreased expression of AKAP12 mRNA CTD PMID:25119042 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO [PD 0325901 co-treated with MK 2206] results in increased phosphorylation of AKT1 protein; [PD 0325901 co-treated with silmitasertib] results in decreased phosphorylation of AKT1 protein; PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]; romidepsin inhibits the reaction [[PD 0325901 co-treated with MK 2206] results in increased phosphorylation of AKT1 protein]
PD 0325901 results in increased phosphorylation of AKT1 protein
CTD PMID:22415236 PMID:25798061 PMID:27634878 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin decreases expression EXP PD 0325901 results in decreased expression of ALB protein CTD PMID:21976371 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ank3 ankyrin 3 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ANK3 mRNA CTD PMID:25119042 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Ano1 anoctamin 1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of ANO1 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ANO1 mRNA
CTD PMID:25119042 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases expression ISO PD 0325901 results in decreased expression of ANPEP mRNA CTD PMID:25119042 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ARHGAP24 mRNA CTD PMID:25119042 NCBI chr14:6,800,631...7,184,001
Ensembl chr14:6,800,631...7,183,823
JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C decreases expression ISO PD 0325901 results in decreased expression of ARL4C mRNA CTD PMID:25119042 NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
ISO PD 0325901 results in increased expression of BAK1 protein
[PD 0325901 co-treated with MK 2206] results in increased expression of BAK1 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of BAK1 protein; [romidepsin co-treated with PD 0325901] results in increased expression of BAK1 protein
CTD PMID:27634878 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO [PD 0325901 co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with PD 0325901] results in increased expression of BCL2L11 protein; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [PD 0325901 results in increased expression of BCL2L11 protein]]; KRAS protein affects the reaction [PD 0325901 results in increased expression of BCL2L11 protein]; NVP-BKM120 promotes the reaction [PD 0325901 results in increased expression of BCL2L11 protein] CTD PMID:24576621 PMID:27634878 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of BID mRNA; [PD 0325901 co-treated with MK 2206] results in increased expression of BID protein modified form CTD PMID:28691888 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of BIRC3 mRNA CTD PMID:25119042 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of CCL20 mRNA
PD 0325901 results in decreased expression of CCL20 mRNA
CTD PMID:25119042 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO PD 0325901 inhibits the reaction [camostat results in increased expression of CCND1 protein] CTD PMID:25104499 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO PD 0325901 inhibits the reaction [camostat results in increased expression of CCND3 protein] CTD PMID:25104499 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO PD 0325901 inhibits the reaction [camostat results in increased expression of CCNE1 protein] CTD PMID:25104499 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of CXCL1 mRNA
PD 0325901 results in decreased expression of CXCL1 mRNA
CTD PMID:25119042 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of CXCL1 mRNA
PD 0325901 results in decreased expression of CXCL1 mRNA
CTD PMID:25119042 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyb5r2 cytochrome b5 reductase 2 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of CYB5R2 mRNA
PD 0325901 results in decreased expression of CYB5R2 mRNA
CTD PMID:25119042 NCBI chr 1:161,655,862...161,664,359
Ensembl chr 1:161,655,864...161,664,097
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression
increases expression
EXP PD 0325901 results in decreased expression of CYP24A1 mRNA
PD 0325901 results in increased expression of CYP24A1 mRNA
CTD PMID:21976371 PMID:23872713 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP PD 0325901 results in increased expression of CYP27B1 mRNA CTD PMID:21976371 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO PD 0325901 results in increased expression of CYP3A4 mRNA CTD PMID:24819614 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO PD 0325901 results in increased expression of CYP3A5 mRNA CTD PMID:24819614 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dcbld2 discoidin, CUB and LCCL domain containing 2 decreases expression ISO PD 0325901 results in decreased expression of DCBLD2 mRNA CTD PMID:25119042 NCBI chr11:42,125,787...42,179,927
Ensembl chr11:42,125,787...42,179,697
JBrowse link
G Dnmbp dynamin binding protein decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of DNMBP mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DNMBP mRNA
CTD PMID:25119042 NCBI chr 1:242,736,189...242,829,498
Ensembl chr 1:242,736,189...242,802,604
JBrowse link
G Dock4 dedicator of cytokinesis 4 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DOCK4 mRNA
PD 0325901 results in decreased expression of DOCK4 mRNA
CTD PMID:25119042 NCBI chr 6:57,512,929...57,902,597
Ensembl chr 6:57,512,908...57,901,855
JBrowse link
G Dusp4 dual specificity phosphatase 4 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of DUSP4 mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DUSP4 mRNA
CTD PMID:25119042 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DUSP6 mRNA
PD 0325901 results in decreased expression of DUSP6 mRNA
CTD PMID:25119042 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Efna5 ephrin A5 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of EFNA5 mRNA CTD PMID:25119042 NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413
JBrowse link
G Egr1 early growth response 1 decreases expression
multiple interactions
EXP
ISO
PD 0325901 results in decreased expression of EGR1 mRNA
PD 0325901 inhibits the reaction [camostat results in increased expression of EGR1 mRNA]
CTD PMID:21976371 PMID:25104499 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Ku 0063794 co-treated with PD 0325901] results in decreased phosphorylation of EIF4EBP1 protein; PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:22415236 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Emp1 epithelial membrane protein 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of EMP1 mRNA
PD 0325901 results in decreased expression of EMP1 mRNA
CTD PMID:25119042 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO PD 0325901 inhibits the reaction [Cisplatin results in increased expression of ERCC1 mRNA]; PD 0325901 inhibits the reaction [Cisplatin results in increased expression of ERCC1 protein]
PD 0325901 results in decreased expression of ERCC1 mRNA
CTD PMID:21996734 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit increases expression ISO PD 0325901 results in increased expression of ERCC4 mRNA CTD PMID:21996734 NCBI chr10:2,416,259...2,448,364 JBrowse link
G Esm1 endothelial cell-specific molecule 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ESM1 mRNA
PD 0325901 results in decreased expression of ESM1 mRNA
CTD PMID:25119042 NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETS1 mRNA CTD PMID:25119042 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Etv1 ETS variant transcription factor 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETV1 mRNA
PD 0325901 results in decreased expression of ETV1 mRNA
CTD PMID:25119042 NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775
JBrowse link
G Etv4 ETS variant transcription factor 4 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETV4 mRNA
PD 0325901 results in decreased expression of ETV4 mRNA
CTD PMID:25119042 NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974
JBrowse link
G Etv5 ETS variant transcription factor 5 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETV5 mRNA
PD 0325901 results in decreased expression of ETV5 mRNA
CTD PMID:25119042 NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO PD 0325901 inhibits the reaction [Protein Kinase Inhibitors inhibits the reaction [FASN protein results in increased expression of UCP1 protein]] CTD PMID:26670611 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions EXP PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK3 protein]; PD 0325901 results in increased expression of and results in increased secretion of FGF23 protein CTD PMID:23872713 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821
JBrowse link
G Fmnl2 formin-like 2 decreases expression ISO PD 0325901 results in decreased expression of FMNL2 mRNA CTD PMID:25119042 NCBI chr 3:37,348,791...37,624,746
Ensembl chr 3:37,348,574...37,624,754
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
EXP
ISO
PD 0325901 results in decreased expression of FOS mRNA
PD 0325901 inhibits the reaction [camostat results in increased expression of FOS mRNA]
CTD PMID:21976371 PMID:25104499 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of FOSL1 protein
[PD 0325901 co-treated with silmitasertib] results in decreased expression of FOSL1 protein
CTD PMID:25798061 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxg1 forkhead box G1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of FOXG1 mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of FOXG1 mRNA
CTD PMID:25119042 NCBI chr 6:66,674,797...66,677,611
Ensembl chr 6:66,666,587...66,678,607
JBrowse link
G Foxo3 forkhead box O3 increases expression
multiple interactions
ISO PD 0325901 results in increased expression of FOXO3 protein
PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of FOXO3 protein]; PD 0325901 promotes the reaction [Luteolin results in increased expression of FOXO3 protein]
CTD PMID:32268164 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Glrx glutaredoxin multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of GLRX mRNA
PD 0325901 results in decreased expression of GLRX mRNA
CTD PMID:25119042 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
JBrowse link
G Gypc glycophorin C (Gerbich blood group) multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of GYPC mRNA
PD 0325901 results in decreased expression of GYPC mRNA
CTD PMID:25119042 NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204
JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HAS2 mRNA
PD 0325901 results in decreased expression of HAS2 mRNA
CTD PMID:25119042 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of HDAC9 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HDAC9 mRNA
CTD PMID:25119042 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HSD17B2 mRNA
PD 0325901 results in decreased expression of HSD17B2 mRNA
CTD PMID:25119042 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of HTR7 mRNA
PD 0325901 results in decreased expression of HTR7 mRNA
CTD PMID:25119042 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Ifng interferon gamma multiple interactions ISO PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein]; PD 0325901 inhibits the reaction [IL15 protein results in increased secretion of IFNG protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased secretion of IFNG protein] CTD PMID:27563819 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of IGFBP3 mRNA CTD PMID:25119042 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il15 interleukin 15 multiple interactions ISO PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein]; PD 0325901 inhibits the reaction [IL15 protein results in increased expression of KLRK1 protein]; PD 0325901 inhibits the reaction [IL15 protein results in increased expression of NCR3 protein]; PD 0325901 inhibits the reaction [IL15 protein results in increased secretion of IFNG protein] CTD PMID:27563819 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il18 interleukin 18 multiple interactions ISO PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein] CTD PMID:27563819 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of IL1B mRNA
PD 0325901 results in decreased expression of IL1B mRNA
CTD PMID:25119042 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of IL1RAPL1 mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of IL1RAPL1 mRNA
CTD PMID:25119042 NCBI chr  X:51,371,969...52,876,726
Ensembl chr  X:51,378,215...52,876,772
JBrowse link
G Il2 interleukin 2 multiple interactions ISO PD 0325901 inhibits the reaction [IL2 protein results in increased expression of KLRK1 protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased expression of NCR3 protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased secretion of IFNG protein] CTD PMID:27563819 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of INHBA mRNA CTD PMID:25119042 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ITGA2 mRNA
PD 0325901 results in decreased expression of ITGA2 mRNA
CTD PMID:25119042 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgbl1 integrin subunit beta like 1 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ITGBL1 mRNA
PD 0325901 results in decreased expression of ITGBL1 mRNA
CTD PMID:25119042 NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP PD 0325901 results in decreased expression of JUN mRNA CTD PMID:21976371 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kif24 kinesin family member 24 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of KIF24 mRNA
PD 0325901 results in decreased expression of KIF24 mRNA
CTD PMID:25119042 NCBI chr 5:56,561,019...56,628,040
Ensembl chr 5:56,561,154...56,628,025
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of KIT mRNA
PD 0325901 results in decreased expression of KIT mRNA
CTD PMID:25119042 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Klrk1 killer cell lectin like receptor K1 multiple interactions ISO PD 0325901 inhibits the reaction [IL15 protein results in increased expression of KLRK1 protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased expression of KLRK1 protein] CTD PMID:27563819 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO KRAS protein affects the reaction [NVP-BKM120 inhibits the reaction [PD 0325901 results in increased phosphorylation of MAPK1 protein]]; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [PD 0325901 results in decreased expression of MCL1 protein]]; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [PD 0325901 results in increased expression of BCL2L11 protein]]; KRAS protein affects the reaction [PD 0325901 inhibits the reaction [NVP-BKM120 results in increased phosphorylation of MAPK1 protein]]; KRAS protein affects the reaction [PD 0325901 promotes the reaction [NVP-BKM120 results in decreased expression of MCL1 protein]]; KRAS protein affects the reaction [PD 0325901 results in decreased expression of MCL1 protein]; KRAS protein affects the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein]; KRAS protein affects the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein]; KRAS protein affects the reaction [PD 0325901 results in increased expression of BCL2L11 protein]; KRAS protein affects the susceptibility to [[PD 0325901 co-treated with NVP-BKM120] results in increased cleavage of PARP1 protein]; KRAS protein affects the susceptibility to [PD 0325901 co-treated with NVP-BKM120]
[PD 0325901 affects the susceptibility to KRAS protein] affects the reaction [NVP-BKM120 results in decreased expression of MKI67 protein]
CTD PMID:24576621 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G LOC100362814 hypothetical protein LOC100362814 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of KIAA1549L mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of KIAA1549L mRNA
CTD PMID:25119042 NCBI chr 3:90,506,559...90,782,427
Ensembl chr 3:90,510,942...90,781,894
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of LPL mRNA CTD PMID:25119042 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lpxn leupaxin multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of LPXN mRNA
PD 0325901 results in decreased expression of LPXN mRNA
CTD PMID:25119042 NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO PD 0325901 inhibits the reaction [Luteolin results in increased expression of and results in increased lipidation of MAP1LC3B protein] CTD PMID:32268164 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein]; [MK 2206 co-treated with PD 0325901] results in decreased phosphorylation of MAPK1 protein; [PD 0325901 co-treated with silmitasertib] results in decreased phosphorylation of MAPK1 protein; dactolisib promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein]; KRAS protein affects the reaction [NVP-BKM120 inhibits the reaction [PD 0325901 results in increased phosphorylation of MAPK1 protein]]; KRAS protein affects the reaction [PD 0325901 inhibits the reaction [NVP-BKM120 results in increased phosphorylation of MAPK1 protein]]; KRAS protein affects the reaction [PD 0325901 results in decreased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [NVP-BKM120 results in increased phosphorylation of MAPK1 protein]; PD 0325901 promotes the reaction [Axitinib results in decreased phosphorylation of MAPK1 protein]; PD 0325901 promotes the reaction [pazopanib results in decreased phosphorylation of MAPK1 protein]; PD 0325901 promotes the reaction [Sunitinib results in decreased phosphorylation of MAPK1 protein]
PD 0325901 inhibits the reaction [camostat results in increased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK1 protein]
PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:21996734 PMID:22415236 PMID:23872713 PMID:24011934 PMID:24576621 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein]; [MK 2206 co-treated with PD 0325901] results in decreased phosphorylation of MAPK3 protein; [PD 0325901 co-treated with silmitasertib] results in decreased phosphorylation of MAPK3 protein; dactolisib promotes the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein]; KRAS protein affects the reaction [PD 0325901 results in decreased phosphorylation of MAPK3 protein]; PD 0325901 inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PD 0325901 inhibits the reaction [Luteolin results in increased phosphorylation of MAPK3 protein]; PD 0325901 inhibits the reaction [NVP-BKM120 results in increased phosphorylation of MAPK3 protein]; PD 0325901 promotes the reaction [Axitinib results in decreased phosphorylation of MAPK3 protein]; PD 0325901 promotes the reaction [pazopanib results in decreased phosphorylation of MAPK3 protein]; PD 0325901 promotes the reaction [Sunitinib results in decreased phosphorylation of MAPK3 protein]
PD 0325901 inhibits the reaction [camostat results in increased phosphorylation of MAPK3 protein]; PD 0325901 inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK3 protein]
PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:21996734 PMID:22415236 PMID:23872713 PMID:24011934 PMID:24576621 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
increases expression
ISO [PD 0325901 co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with PD 0325901 co-treated with MK 2206] results in increased expression of MCL1 protein; [romidepsin co-treated with PD 0325901] results in increased expression of MCL1 protein; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [PD 0325901 results in decreased expression of MCL1 protein]]; KRAS protein affects the reaction [PD 0325901 promotes the reaction [NVP-BKM120 results in decreased expression of MCL1 protein]]; KRAS protein affects the reaction [PD 0325901 results in decreased expression of MCL1 protein]; NVP-BKM120 promotes the reaction [PD 0325901 results in decreased expression of MCL1 protein]; PD 0325901 promotes the reaction [NVP-BKM120 results in decreased expression of MCL1 protein]
PD 0325901 results in increased expression of MCL1 protein
CTD PMID:24576621 PMID:27634878 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mgll monoglyceride lipase multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of MGLL mRNA
PD 0325901 results in decreased expression of MGLL mRNA
CTD PMID:25119042 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [PD 0325901 affects the susceptibility to KRAS protein] affects the reaction [NVP-BKM120 results in decreased expression of MKI67 protein]; PD 0325901 inhibits the reaction [camostat results in increased expression of MKI67 protein] CTD PMID:24576621 PMID:25104499 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmd monocyte to macrophage differentiation-associated multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMD mRNA
PD 0325901 results in decreased expression of MMD mRNA
CTD PMID:25119042 NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMP1 mRNA
PD 0325901 results in decreased expression of MMP1 mRNA
CTD PMID:25119042 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp10 matrix metallopeptidase 10 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMP10 mRNA CTD PMID:25119042 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO PD 0325901 inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK1 protein]; PD 0325901 inhibits the reaction [MTOR gene mutant form results in increased phosphorylation of MAPK3 protein] CTD PMID:29384525 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [PD 0325901 results in decreased expression of MYC protein]; PD 0325901 promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein] CTD PMID:26284497 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nav3 neuron navigator 3 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of NAV3 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of NAV3 mRNA
CTD PMID:25119042 NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698
JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 multiple interactions ISO PD 0325901 inhibits the reaction [IL15 protein results in increased expression of NCR3 protein]; PD 0325901 inhibits the reaction [IL2 protein results in increased expression of NCR3 protein] CTD PMID:27563819 NCBI chr20:3,637,242...3,643,748
Ensembl chr20:3,638,240...3,643,799
JBrowse link
G Nf1 neurofibromin 1 multiple interactions ISO NF1 protein inhibits the reaction [SUZ12 gene mutant form results in increased susceptibility to [(+)-JQ1 compound co-treated with PD 0325901]] CTD PMID:25119042 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Nme5 NME/NM23 family member 5 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of NME5 mRNA CTD PMID:25119042 NCBI chr18:26,163,558...26,180,742
Ensembl chr18:26,163,555...26,180,794
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO PD 0325901 results in decreased expression of NR0B2 mRNA CTD PMID:24819614 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nrcam neuronal cell adhesion molecule decreases expression ISO PD 0325901 results in decreased expression of NRCAM mRNA CTD PMID:25119042 NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
JBrowse link
G Nrp1 neuropilin 1 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of NRP1 mRNA
PD 0325901 results in decreased expression of NRP1 mRNA
CTD PMID:25119042 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Ntm neurotrimin multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of NTM mRNA
PD 0325901 results in decreased expression of NTM mRNA
CTD PMID:25119042 NCBI chr 8:27,376,582...28,366,604
Ensembl chr 8:27,377,773...28,366,595
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [PD 0325901 co-treated with MK 2206] results in increased cleavage of PARP1 protein; [PD 0325901 co-treated with NVP-BKM120] results in increased cleavage of PARP1 protein; KRAS protein affects the susceptibility to [[PD 0325901 co-treated with NVP-BKM120] results in increased cleavage of PARP1 protein]; PD 0325901 promotes the reaction [Luteolin results in increased cleavage of PARP1 protein]; romidepsin promotes the reaction [[PD 0325901 co-treated with MK 2206] results in increased cleavage of PARP1 protein]; romidepsin promotes the reaction [PD 0325901 results in increased cleavage of PARP1 protein] CTD PMID:24576621 PMID:27634878 PMID:32268164 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO PD 0325901 inhibits the reaction [camostat results in increased expression of PCNA protein] CTD PMID:25104499 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of PDCD1LG2 mRNA CTD PMID:25119042 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938
JBrowse link
G Peg3 paternally expressed 3 decreases expression ISO PD 0325901 results in decreased expression of PEG3 mRNA CTD PMID:25119042 NCBI chr 1:67,097,874...67,124,692
Ensembl chr 1:67,097,904...67,124,671
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PLAU mRNA
PD 0325901 results in decreased expression of PLAU mRNA
CTD PMID:25119042 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PLAUR mRNA
PD 0325901 results in decreased expression of PLAUR mRNA
CTD PMID:25119042 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO PD 0325901 inhibits the reaction [Protein Kinase Inhibitors results in increased phosphorylation of and results in decreased activity of PPARG protein] CTD PMID:26670611 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prdm1 PR/SET domain 1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of PRDM1 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of PRDM1 mRNA
CTD PMID:25119042 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Prrx1 paired related homeobox 1 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of PRRX1 mRNA
PD 0325901 results in decreased expression of PRRX1 mRNA
CTD PMID:25119042 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866
JBrowse link
G Ptx3 pentraxin 3 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PTX3 mRNA
PD 0325901 results in decreased expression of PTX3 mRNA
CTD PMID:25119042 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Rac1 Rac family small GTPase 1 affects response to substance ISO RAC1 protein alternative form affects the susceptibility to PD 0325901 CTD PMID:23033341 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Reln reelin decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of RELN mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of RELN mRNA
CTD PMID:25119042 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
ISO 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one promotes the reaction [PD 0325901 results in decreased phosphorylation of RPS6 protein]; PD 0325901 promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein]; PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein]; PD 0325901 promotes the reaction [NVP-BKM120 results in decreased phosphorylation of RPS6 protein] CTD PMID:22415236 PMID:24011934 PMID:24576621 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Scg5 secretogranin V multiple interactions ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of SCG5 mRNA CTD PMID:25119042 NCBI chr 3:100,544,101...100,588,558
Ensembl chr 3:100,544,099...100,588,463
JBrowse link
G Sema3a semaphorin 3A multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SEMA3A mRNA
PD 0325901 results in decreased expression of SEMA3A mRNA
CTD PMID:25119042 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432
JBrowse link
G Siglec15 sialic acid binding Ig-like lectin 15 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of SIGLEC15 mRNA
PD 0325901 results in decreased expression of SIGLEC15 mRNA
CTD PMID:25119042 NCBI chr18:71,507,773...71,521,722
Ensembl chr18:71,505,399...71,521,881
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SLC6A15 mRNA
PD 0325901 results in decreased expression of SLC6A15 mRNA
CTD PMID:25119042 NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239
JBrowse link
G Slit2 slit guidance ligand 2 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SLIT2 mRNA
PD 0325901 results in decreased expression of SLIT2 mRNA
CTD PMID:25119042 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO PD 0325901 results in decreased expression of SOX9 mRNA CTD PMID:25119042 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SPP1 mRNA CTD PMID:25119042 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SPRY2 mRNA
PD 0325901 results in decreased expression of SPRY2 mRNA
CTD PMID:25119042 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ST3GAL6 mRNA
PD 0325901 results in decreased expression of ST3GAL6 mRNA
CTD PMID:25119042 NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776
JBrowse link
G Stc1 stanniocalcin 1 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of STC1 mRNA
[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of STC1 mRNA
CTD PMID:25119042 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Stx1a syntaxin 1A multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of STX1A mRNA
PD 0325901 results in decreased expression of STX1A mRNA
CTD PMID:25119042 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions ISO NF1 protein inhibits the reaction [SUZ12 gene mutant form results in increased susceptibility to [(+)-JQ1 compound co-treated with PD 0325901]]; SUZ12 gene mutant form results in increased susceptibility to [(+)-JQ1 compound co-treated with PD 0325901] CTD PMID:25119042 NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 affects response to substance ISO SYNGAP1 protein affects the susceptibility to PD 0325901 CTD PMID:29940508 NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672
JBrowse link
G Tbx3 T-box transcription factor 3 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TBX3 mRNA
PD 0325901 results in decreased expression of TBX3 mRNA
CTD PMID:25119042 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TFPI mRNA
PD 0325901 results in decreased expression of TFPI mRNA
CTD PMID:25119042 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TGM2 mRNA
PD 0325901 results in decreased expression of TGM2 mRNA
CTD PMID:25119042 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression
multiple interactions
ISO PD 0325901 results in decreased expression of TLR4 mRNA
[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TLR4 mRNA
CTD PMID:25119042 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmem156 transmembrane protein 156 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TMEM156 mRNA
PD 0325901 results in decreased expression of TMEM156 mRNA
CTD PMID:25119042 NCBI chr14:43,221,464...43,252,453
Ensembl chr14:43,223,381...43,252,449
JBrowse link
G Tnfsf15 TNF superfamily member 15 multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of TNFSF15 mRNA
PD 0325901 results in decreased expression of TNFSF15 mRNA
CTD PMID:25119042 NCBI chr 5:77,140,099...77,156,142
Ensembl chr 5:77,139,878...77,156,228
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [PD 0325901 co-treated with MK 2206] results in increased expression of and results in increased phosphorylation of TRP53 protein CTD PMID:28691888 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trib2 tribbles pseudokinase 2 multiple interactions
decreases expression
ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of TRIB2 mRNA
PD 0325901 results in decreased expression of TRIB2 mRNA
CTD PMID:25119042 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO PD 0325901 inhibits the reaction [Protein Kinase Inhibitors inhibits the reaction [FASN protein results in increased expression of UCP1 protein]] CTD PMID:26670611 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ugt8 UDP glycosyltransferase 8 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of UGT8 mRNA CTD PMID:25119042 NCBI chr 2:214,264,483...214,332,769
Ensembl chr 2:214,264,483...214,332,660
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions
decreases expression
ISO [(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of VEGFC mRNA
PD 0325901 results in decreased expression of VEGFC mRNA
CTD PMID:25119042 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions ISO [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ZEB1 mRNA CTD PMID:25119042 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
selumetinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2 like 11 increases expression ISO AZD 6244 results in increased expression of BCL2L11 protein CTD PMID:22729845 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO AZD 6244 promotes the reaction [Calcitriol promotes the reaction [resveratrol results in increased expression of CAMP mRNA]]; AZD 6244 promotes the reaction [resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]] CTD PMID:24039193 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP3 protein]]
Doxorubicin promotes the reaction [AZD 6244 results in increased cleavage of CASP3 protein]
CTD PMID:17876044 PMID:27222248 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases cleavage
multiple interactions
ISO AZD 6244 results in increased cleavage of CASP7 protein
Doxorubicin promotes the reaction [AZD 6244 results in increased cleavage of CASP7 protein]
CTD PMID:17876044 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP8 protein]] CTD PMID:27222248 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccnb1 cyclin B1 decreases expression
multiple interactions
ISO AZD 6244 results in decreased expression of CCNB1 protein
Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of CCNB1 protein]
CTD PMID:17876044 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO AZD 6244 results in decreased expression of and results in decreased phosphorylation of CCND1 protein; Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of and results in decreased phosphorylation of CCND1 protein] CTD PMID:17876044 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases expression
ISO Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of CDK2 protein] CTD PMID:17876044 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions
ISO AZD 6244 results in decreased expression of CDK4 protein
Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of CDK4 protein]
CTD PMID:17876044 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO AZD 6244 promotes the reaction [decitabine results in increased expression of CDKN1A] CTD PMID:19422044 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions ISO AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein] CTD PMID:27805061 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation ISO AZD 6244 results in decreased phosphorylation of CREB1 protein CTD PMID:31790661 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Ku 0063794 co-treated with AZD 6244] results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:22415236 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation ISO AZD 6244 results in decreased phosphorylation of FOS protein CTD PMID:31790661 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO selumetinib increases phosphorylation of JAK2 protein in colonic epithelium RGD PMID:30706361 RGD:127285668 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP3 protein]]; AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of CASP8 protein]]; AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of PARP1 protein]]; AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased expression of TNFRSF10B protein]; AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased phosphorylation of MAPK1 protein]; AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased phosphorylation of MAPK3 protein]; AZD 6244 inhibits the reaction [KRAS protein mutant form affects the susceptibility to vemurafenib] CTD PMID:27222248 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased phosphorylation of MAPK1 protein]
AZD 6244 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Doxorubicin promotes the reaction [AZD 6244 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]
AZD 6244 results in decreased phosphorylation of MAPK1 protein
CTD PMID:17876044 PMID:22415236 PMID:27222248 PMID:31790661 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased phosphorylation of MAPK3 protein]
AZD 6244 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Doxorubicin promotes the reaction [AZD 6244 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]
AZD 6244 results in decreased phosphorylation of MAPK3 protein
CTD PMID:17876044 PMID:22415236 PMID:27222248 PMID:31790661 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases activity ISO AZD 6244 results in decreased activity of MMP1 protein CTD PMID:31790661 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO AZD 6244 results in decreased activity of MMP2 protein CTD PMID:31790661 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO AZD 6244 results in decreased activity of MMP9 protein CTD PMID:31790661 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of MYC protein] CTD PMID:17876044 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO AZD 6244 results in increased cleavage of PARP1 protein
Doxorubicin promotes the reaction [AZD 6244 results in increased cleavage of PARP1 protein]
AZD 6244 inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] promotes the reaction [TNFRSF10B protein results in increased cleavage of PARP1 protein]]
CTD PMID:17876044 PMID:27222248 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions
decreases phosphorylation
ISO Doxorubicin promotes the reaction [AZD 6244 results in decreased phosphorylation of RPS6KA1 protein] CTD PMID:17876044 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 mRNA]; AZD 6244 inhibits the reaction [flavone results in increased expression of SOCS3 protein] CTD PMID:23782265 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA] CTD PMID:27805061 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          nitrogen atom 18765
            nitrogen molecular entity 18765
              organonitrogen compound 18538
                carboxamide 17299
                  hydroxamic acid ester 147
                    4-amino-1,2-oxazolidin-3-one + 7
                    Furmecyclox 0
                    GDC-0623 0
                    PD 0325901 129
                    binimetinib 1
                    selumetinib 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                hydroxamic acid 6283
                                                  hydroxamic acid ester 147
                                                    4-amino-1,2-oxazolidin-3-one + 7
                                                    Furmecyclox 0
                                                    GDC-0623 0
                                                    PD 0325901 129
                                                    binimetinib 1
                                                    selumetinib 26
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