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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbocyclic thromboxane A2
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Accession:CHEBI:139043 term browser browse the term
Definition:A member of the class of thromboxanes that is thromboxane A2 in which the bridging oxygen has been replaced by a methylene group.
Synonyms:exact_synonym: (5Z)-7-{(1R,3R,4S,5R)-3-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[3.1.1]heptan-4-yl}hept-5-enoic acid
 related_synonym: 9alpha,11alpha-methylene thromboxane A2;   9alpha,11alpha-methylene-TXA2;   Formula=C21H34O4;   InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-20-19(16-14-18(15-16)25-20)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17-,18+,19-,20+/m0/s1;   InChIKey=VQUUFWNZZIMDBR-SXNJQZKASA-N;   SMILES=C1[C@H]2[C@@H]([C@H](O[C@@H]1C2)/C=C/[C@H](CCCCC)O)C/C=C\\CCCC(=O)O;   carbocyclic TXA2
 xref_mesh: MESH:C024587
 xref: PMID:10542977;   PMID:11483590;   PMID:12614148;   PMID:12628222;   PMID:1561230;   PMID:15789615;   PMID:16093422;   PMID:16896186;   PMID:17109692;   PMID:1838696;   PMID:3387452;   PMID:3512276;   PMID:6754126;   PMID:6960809;   PMID:7591017;   PMID:7693541;   PMID:7966472;   PMID:8135127;   PMID:8831114;   PMID:9014151;   PMID:9342927
 cyclic_relationship: is_conjugate_acid_of CHEBI:138322


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carbocyclic thromboxane A2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression ISO thromboxane A2, carbocyclic results in decreased expression of TNFRSF11B mRNA CTD PMID:18264100 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression ISO thromboxane A2, carbocyclic results in increased expression of TNFSF11 mRNA CTD PMID:18264100 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        pharmacological role 19098
          agonist 18630
            thromboxane A2 agonist 2
              carbocyclic thromboxane A2 2
                18-hydroxycarbocyclic thromboxane A2 0
                19-hydroxycarbocyclic thromboxane A2 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      monocarboxylic acid 18017
                                        fatty acid 16843
                                          fatty acid derivative 8989
                                            icosanoid 471
                                              prostanoid 407
                                                thromboxane 16
                                                  thromboxanes A 10
                                                    thromboxane A2 10
                                                      carbocyclic thromboxane A2 2
                                                        18-hydroxycarbocyclic thromboxane A2 0
                                                        19-hydroxycarbocyclic thromboxane A2 0
paths to the root