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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thromboxane A2
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Accession:CHEBI:15627 term browser browse the term
Definition:A thromboxane which is produced by activated platelets and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation.
Synonyms:exact_synonym: (5Z,13E,15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dien-1-oic acid
 related_synonym: (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate;   (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-oic acid;   9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid;   Formula=C20H32O5;   InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1;   InChIKey=DSNBHJFQCNUKMA-SCKDECHMSA-N;   SMILES=CCCCC[C@H](O)\\C=C\\[C@H]1O[C@H]2C[C@H](O2)[C@@H]1C\\C=C/CCCC(O)=O;   TXA-2;   TXA2
 alt_id: CHEBI:10915;   CHEBI:18589;   CHEBI:26993;   CHEBI:9575
 xref: CAS:57576-52-0;   KEGG:C02198;   LIPID_MAPS_instance:LMFA03030001
 xref_mesh: MESH:D013928
 cyclic_relationship: is_conjugate_acid_of CHEBI:57445


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thromboxane A2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col10a1 collagen type X alpha 1 chain increases expression ISO Thromboxane A2 results in increased expression of COL10A1 mRNA; Thromboxane A2 results in increased expression of COL10A1 protein CTD PMID:27050768 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G F2 coagulation factor II multiple interactions
increases abundance
ISO Indomethacin inhibits the reaction [F2 protein results in increased abundance of Thromboxane A2 metabolite]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [F2 protein results in increased abundance of Thromboxane A2 metabolite] CTD PMID:10027849 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite] CTD PMID:17641673 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Pla2g2a phospholipase A2 group IIA increases abundance
multiple interactions
ISO PLA2G2A protein results in increased abundance of Thromboxane A2 metabolite
varespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane A2 metabolite]
CTD PMID:10027849 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions
increases chemical synthesis
affects chemical synthesis
ISO [Aspirin results in increased acetylation of PTGS1 protein] which results in decreased chemical synthesis of Thromboxane A2
PTGS1 results in increased chemical synthesis of Thromboxane A2
PTGS1 gene SNP affects the chemical synthesis of Thromboxane A2
CTD PMID:15863457, PMID:16150050, PMID:16484611 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases chemical synthesis
multiple interactions
ISO PTGS2 results in increased chemical synthesis of Thromboxane A2
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Thromboxane A2; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Thromboxane A2
PTGS2 protein results in increased chemical synthesis of Thromboxane A2
1-phenyl-6,7-dihydroxy-isochroman inhibits the reaction [[Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Thromboxane A2]; [Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Thromboxane A2
CTD PMID:14726416, PMID:15863457, PMID:21269535, PMID:27050768 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Thromboxane A2 results in increased expression of RUNX2 mRNA; Thromboxane A2 results in increased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
carbocyclic thromboxane A2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression ISO thromboxane A2, carbocyclic results in decreased expression of TNFRSF11B mRNA CTD PMID:18264100 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression ISO thromboxane A2, carbocyclic results in increased expression of TNFSF11 mRNA CTD PMID:18264100 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        main group molecular entity 19670
          gas molecular entity 17546
            oxirane 5746
              epoxide 5744
                epoxy monocarboxylic acid 24
                  thromboxane A2 9
                    18-hydroxythromboxane A2 0
                    19-hydroxythromboxane A2 0
                    carbocyclic thromboxane A2 + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          fatty acid 15844
                                            fatty acid derivative 1021
                                              icosanoid 453
                                                prostanoid 395
                                                  thromboxane 15
                                                    thromboxanes A 9
                                                      thromboxane A2 9
                                                        18-hydroxythromboxane A2 0
                                                        19-hydroxythromboxane A2 0
                                                        carbocyclic thromboxane A2 + 2
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