Nr3c1 directly, by binding to GREs or in some cases negative GREs, or indirectly via protein-protein interactions positively or negatively regulates the expression of many genes. A powerful immunoregulator, Nr3c1 enhances the expression of anti-inflammatory proteins while repressing the expression of pro-inflammatory ones [for more details, check PMIDs 21224015 and 21198556]. Several targets are listed with aliases in parentheses, full names and links to gene report pages:

Upregulated genes
Anxa1 (lipocortin 1) – annexin A1
Adrb2 (B2AR, ADRBR) – adrenoreceptor beta 2
Nfkbia (IKBA, Mad-3) – NFKB inhibitor alpha
Dusp1 (Mkp-1, Mkp1) – dual specificity phosphatase 1
Tsc22d3 (Dsipi, Gilz) – TSC22 domain family, member 3
Il10 (CSIF, IL10X) – interleukin 10
Il12b (Il12) – interleukin 12B
Il1rn (DIRA, IRAP, IL-1RN) – interleukin 1 receptor antagonist

Downregulated genes
Il2 (IL-2) – interleukin 2
Il3 (IL-3, MCGF) – interleukin 3
Il4 (IL-4, BSF-1) – interleukin 4
Il5 (TRF, IL-5, BCGF-II) – interleukin 5
Il6 (IL-6) – interleukin 6
IL13 (IL-13) – interleukin 13
IL15 (IL-15) – interleukin 15
Tnf (Tnfa, TNF-alpha) – tumor necrosis factor
Tslp – thymic stromal lymphopoietin
Ccl1 (TCA-3) – C-C motif chemokine ligand 1
Ccl5 (SIS-delta, Rantes, Scya5) – C-C motif chemokine ligand 5
Ccl11 (Scya11) – C-C motif chemokine ligand 11
IL8 (CXCL8, NAF, GCP1, NAP1) – interleukin 8 (human gene)
Nos2 (iNos, Nos2a) – nitric oxide synthase 2
Pla2g4a (cPLA2, Pla2c) – phospholipase A2 group IVA
Edn1 (Et1, ET-1) – endothelin 1
Pomc – proopiomelanocortin