Fdps (farnesyl diphosphate synthase) - Rat Genome Database

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Gene: Fdps (farnesyl diphosphate synthase) Rattus norvegicus
Analyze
Symbol: Fdps
Name: farnesyl diphosphate synthase
RGD ID: 68953
Description: Enables (2E,6E)-farnesyl diphosphate synthase activity. Involved in several processes, including farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Located in mitochondrial matrix and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: (2E,6E)-farnesyl diphosphate synthase; Ac2-125; cholesterol-regulated 39 kDa protein; CR 39; dimethylallyltranstransferase; farensyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; Farnesyldiphosphate synthase; FPP synthase; FPP synthetase; FPS; geranyltranstransferase; testis-specific farnesyl pyrophosphate synthetase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,795,192 - 176,804,816 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2176,795,192 - 176,807,136 (-)EnsemblGRCr8
mRatBN7.22174,497,402 - 174,507,031 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,486,665 - 174,507,776 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2181,643,561 - 181,653,177 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,665,921 - 179,675,537 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,265,880 - 174,275,498 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,403,595 - 188,413,219 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,392,858 - 188,413,219 (-)Ensemblrn6Rnor6.0
Rnor_5.02207,816,332 - 207,826,348 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42181,138,474 - 181,177,903 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,441,483 - 168,451,110 (-)NCBICelera
RGSC_v3.12181,119,007 - 181,128,009 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
Actein  (EXP)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
alendronic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bromobenzene  (EXP)
Bufotalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
cholesterol  (EXP)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Di-n-hexyl phthalate  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
Dicyclohexyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
Ganoderic acid A  (ISO)
glafenine  (EXP)
hexaconazole  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
iodide salt  (EXP)
isopentenyl diphosphate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
lead nitrate  (EXP)
loperamide  (ISO)
lovastatin  (EXP,ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methyltestosterone  (ISO)
mevalonic acid  (EXP)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nickel dichloride  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
pamidronate  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (ISO)
picoxystrobin  (ISO)
pinosylvin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
Risedronate sodium  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trans-pinosylvin  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (ISO)
mitochondrial matrix  (IDA,IEA,ISO)
peroxisome  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats. Alsebaaly J, etal., Front Mol Neurosci. 2018 Dec 13;11:457. doi: 10.3389/fnmol.2018.00457. eCollection 2018.
2. Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetase. Ashby MN and Edwards PA, J Biol Chem. 1989 Jan 5;264(1):635-40.
3. Alendronate lowers cholesterol synthesis in the central nervous system of rats - a preliminary study. CIBICKOVA L, etal., Physiol Res. 2009;58(3):455-8. Epub 2008 Jul 18.
4. Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway. Clarke CF, etal., Mol Cell Biol 1987 Sep;7(9):3138-46.
5. An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains. Dracheva SV, etal., Genomics 2000 Jan 15;63(2):202-26.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism. Gupta SD, etal., J Lipid Res. 1999 Sep;40(9):1572-84.
9. Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. Heemers H, etal., Mol Cell Endocrinol. 2003 Jul 31;205(1-2):21-31.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Kovacs WJ, etal., Histochem Cell Biol. 2007 Mar;127(3):273-90. Epub 2006 Dec 19.
12. Farnesyl-diphosphate synthase is localized in peroxisomes. Krisans SK, etal., J Biol Chem. 1994 May 13;269(19):14165-9.
13. Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. Le Jossic-Corcos C, etal., Biochem J. 2005 Feb 1;385(Pt 3):787-94.
14. Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents. Le Jossic-Corcos C, etal., J Steroid Biochem Mol Biol. 2004 Feb;88(2):203-11.
15. Pituitary regulation of the expression of the farnesyl pyrophosphate synthetase gene in the testes of the sexually maturing rat. Nazian SJ, etal., J Androl. 1991 Jul-Aug;12(4):264-72.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans-prenyltransferase. Runquist M, etal., J Biol Chem. 1994 Feb 25;269(8):5804-9.
25. Molecular cloning and promoter analysis of the rat liver farnesyl diphosphate synthase gene. Spear DH, etal., J Biol Chem 1992 Jul 15;267(20):14462-9.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells. Teruya JH, etal., Biol Reprod. 1991 Apr;44(4):663-71.
28. Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA. Teruya JH, etal., Mol Cell Biol 1990 May;10(5):2315-26.
29. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
30. Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway. Ye Y, etal., FEBS Lett. 2009 Sep 17;583(18):2997-3003. Epub 2009 Aug 28.
Additional References at PubMed
PMID:18614015   PMID:19800872   PMID:22658674   PMID:24527834   PMID:24625528   PMID:25847782  


Genomics

Comparative Map Data
Fdps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,795,192 - 176,804,816 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2176,795,192 - 176,807,136 (-)EnsemblGRCr8
mRatBN7.22174,497,402 - 174,507,031 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,486,665 - 174,507,776 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2181,643,561 - 181,653,177 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,665,921 - 179,675,537 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,265,880 - 174,275,498 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,403,595 - 188,413,219 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,392,858 - 188,413,219 (-)Ensemblrn6Rnor6.0
Rnor_5.02207,816,332 - 207,826,348 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42181,138,474 - 181,177,903 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,441,483 - 168,451,110 (-)NCBICelera
RGSC_v3.12181,119,007 - 181,128,009 (-)NCBI
Cytogenetic Map2q34NCBI
FDPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,308,866 - 155,320,665 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,304,786 - 155,320,666 (+)Ensemblhg38GRCh38
GRCh371155,278,657 - 155,290,456 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,545,374 - 153,557,080 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341152,092,649 - 152,103,529NCBI
Celera1128,351,680 - 128,363,599 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,640,838 - 126,652,759 (+)NCBIHuRef
CHM1_11156,673,976 - 156,685,898 (+)NCBICHM1_1
T2T-CHM13v2.01154,447,406 - 154,459,205 (+)NCBIT2T-CHM13v2.0
Fdps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,000,895 - 89,009,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,000,895 - 89,009,266 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38389,093,588 - 89,101,967 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,093,588 - 89,101,959 (-)Ensemblmm10GRCm38
MGSCv37388,897,510 - 88,905,867 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36389,179,515 - 89,187,872 (-)NCBIMGSCv36mm8
Celera389,132,279 - 89,140,636 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
Fdps
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,757,418 - 1,765,028 (+)Ensembl
ChiLan1.0NW_0049555451,757,090 - 1,765,028 (+)NCBIChiLan1.0ChiLan1.0
FDPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,523,831 - 94,535,834 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,255,158 - 94,267,161 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,653,316 - 130,665,196 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,258,881 - 134,270,237 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,258,968 - 134,270,237 (+)EnsemblpanPan2panpan1.1
FDPS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,241,086 - 42,250,373 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,241,107 - 42,250,225 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha741,731,911 - 41,741,200 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0742,110,187 - 42,119,478 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,110,191 - 42,119,346 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,890,063 - 41,899,349 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,943,839 - 41,953,128 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,227,832 - 42,237,121 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fdps
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,768,903 - 25,778,024 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,799,637 - 4,808,424 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,799,354 - 4,808,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDPS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,500,141 - 94,518,408 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1494,500,140 - 94,514,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,291,797 - 103,304,940 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FDPS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,514,311 - 8,526,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660387,851,669 - 7,864,161 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdps
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624885943,571 - 949,528 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624885942,998 - 949,529 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fdps
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1364,575,456 - 64,585,248 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fdps
310 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:142
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000033917, ENSRNOT00000065065
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
D2Arb36  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82176,805,166 - 176,805,378 (+)Marker Load Pipeline
mRatBN7.22174,507,381 - 174,507,593 (+)MAPPERmRatBN7.2
Rnor_6.02188,413,570 - 188,413,781NCBIRnor6.0
Rnor_5.02207,826,699 - 207,826,910UniSTSRnor5.0
RGSC_v3.42181,178,253 - 181,178,466RGDRGSC3.4
RGSC_v3.42181,178,254 - 181,178,466UniSTSRGSC3.4
Celera2168,451,461 - 168,451,672UniSTS
RGSC_v3.12181,128,359 - 181,128,572RGD
Cytogenetic Map2q34UniSTS
RH127967  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q34UniSTS
AA408288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,487,951 - 174,488,122 (+)MAPPERmRatBN7.2
Rnor_6.02188,394,145 - 188,394,315NCBIRnor6.0
Rnor_5.02207,806,504 - 207,806,674UniSTSRnor5.0
RGSC_v3.42181,157,880 - 181,158,050UniSTSRGSC3.4
Celera2168,432,196 - 168,432,366UniSTS
Cytogenetic Map2q34UniSTS
AW534365  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82176,786,125 - 176,786,244 (+)Marker Load Pipeline
mRatBN7.22174,488,335 - 174,488,454 (+)MAPPERmRatBN7.2
Rnor_6.02188,394,529 - 188,394,647NCBIRnor6.0
Rnor_5.02207,806,888 - 207,807,006UniSTSRnor5.0
RGSC_v3.42181,158,264 - 181,158,382UniSTSRGSC3.4
Celera2168,432,580 - 168,432,698UniSTS
RH 3.4 Map21160.7UniSTS
Cytogenetic Map2q34UniSTS
RH128237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,488,052 - 174,488,233 (+)MAPPERmRatBN7.2
Rnor_6.02188,394,246 - 188,394,426NCBIRnor6.0
Rnor_5.02207,806,605 - 207,806,785UniSTSRnor5.0
RGSC_v3.42181,157,981 - 181,158,161UniSTSRGSC3.4
Celera2168,432,297 - 168,432,477UniSTS
RH 3.4 Map21156.2UniSTS
Cytogenetic Map2q34UniSTS
BQ193911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,486,692 - 174,486,851 (+)MAPPERmRatBN7.2
Rnor_6.02188,392,886 - 188,393,044NCBIRnor6.0
Rnor_5.02207,805,245 - 207,805,403UniSTSRnor5.0
RGSC_v3.42181,156,621 - 181,156,779UniSTSRGSC3.4
Celera2168,430,937 - 168,431,095UniSTS
RH 3.4 Map21162.0UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M89945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000033917   ⟹   ENSRNOP00000031191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,486,665 - 174,506,182 (-)Ensembl
Rnor_6.0 Ensembl2188,392,858 - 188,412,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065065   ⟹   ENSRNOP00000058918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,795,192 - 176,807,136 (-)Ensembl
mRatBN7.2 Ensembl2174,497,399 - 174,506,141 (-)Ensembl
Rnor_6.0 Ensembl2188,403,595 - 188,413,219 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080185   ⟹   ENSRNOP00000070394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,795,195 - 176,803,964 (-)Ensembl
mRatBN7.2 Ensembl2174,497,405 - 174,506,923 (-)Ensembl
Rnor_6.0 Ensembl2188,403,583 - 188,412,362 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094500   ⟹   ENSRNOP00000083196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,487,922 - 174,493,757 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103438   ⟹   ENSRNOP00000096239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,487,922 - 174,507,776 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118716   ⟹   ENSRNOP00000076679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,487,922 - 174,507,362 (-)Ensembl
RefSeq Acc Id: NM_031840   ⟹   NP_114028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,795,192 - 176,804,816 (-)NCBI
mRatBN7.22174,497,402 - 174,507,031 (-)NCBI
Rnor_6.02188,403,595 - 188,413,219 (-)NCBI
Rnor_5.02207,816,332 - 207,826,348 (-)NCBI
RGSC_v3.42181,138,474 - 181,177,903 (-)RGD
Celera2168,441,483 - 168,451,110 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40960 (Get FASTA)   NCBI Sequence Viewer  
  AAA41143 (Get FASTA)   NCBI Sequence Viewer  
  AAH59125 (Get FASTA)   NCBI Sequence Viewer  
  EDM00669 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058918
GenBank Protein P05369 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114028   ⟸   NM_031840
- UniProtKB: Q6GT82 (UniProtKB/Swiss-Prot),   P05369 (UniProtKB/Swiss-Prot),   A6J6C0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031191   ⟸   ENSRNOT00000033917
Ensembl Acc Id: ENSRNOP00000070394   ⟸   ENSRNOT00000080185
Ensembl Acc Id: ENSRNOP00000058918   ⟸   ENSRNOT00000065065
Ensembl Acc Id: ENSRNOP00000076679   ⟸   ENSRNOT00000118716
Ensembl Acc Id: ENSRNOP00000083196   ⟸   ENSRNOT00000094500
Ensembl Acc Id: ENSRNOP00000096239   ⟸   ENSRNOT00000103438
Protein Domains
RUN   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05369-F1-model_v2 AlphaFold P05369 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691456
Promoter ID:EPDNEW_R1981
Type:initiation region
Name:Fdps_1
Description:farnesyl diphosphate synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,413,113 - 188,413,173EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68953 AgrOrtholog
BioCyc Gene G2FUF-52455 BioCyc
BioCyc Pathway PWY-5122 [geranyl diphosphate biosynthesis] BioCyc
  PWY-5123 [trans, trans-farnesyl diphosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY-5122 BioCyc
  PWY-5123 BioCyc
Ensembl Genes ENSRNOG00000043377 Ensembl
  ENSRNOG00000077379 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000065065 ENTREZGENE
Gene3D-CATH 1.10.600.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6919326 IMAGE-MGC_LOAD
InterPro FPS1-like UniProtKB/Swiss-Prot
  Isoprenoid_synthase_dom_sf UniProtKB/Swiss-Prot
  Polyprenyl_synt UniProtKB/Swiss-Prot
  Polyprenyl_synt_CS UniProtKB/Swiss-Prot
KEGG Report rno:83791 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72758 IMAGE-MGC_LOAD
NCBI Gene 83791 ENTREZGENE
PANTHER FARNESYL PYROPHOSPHATE SYNTHASE UniProtKB/Swiss-Prot
  FARNESYL-PYROPHOSPHATE SYNTHETASE UniProtKB/Swiss-Prot
Pfam polyprenyl_synt UniProtKB/Swiss-Prot
PharmGKB FDPS RGD
PhenoGen Fdps PhenoGen
PROSITE POLYPRENYL_SYNTHASE_1 UniProtKB/Swiss-Prot
  POLYPRENYL_SYNTHASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000043377 RatGTEx
  ENSRNOG00000077379 RatGTEx
Superfamily-SCOP SSF48576 UniProtKB/Swiss-Prot
UniProt A0A0G2JXT3_RAT UniProtKB/TrEMBL
  A6J6C0 ENTREZGENE, UniProtKB/TrEMBL
  F1LND7_RAT UniProtKB/TrEMBL
  FPPS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6GT82 ENTREZGENE
  Q7TPK0_RAT UniProtKB/TrEMBL
UniProt Secondary Q6GT82 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Fdps  farnesyl diphosphate synthase  Fdps  farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Fdps  farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)  Fdps  farnesyl diphosphate synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Fdps  farnesyl diphosphate synthetase  Fdps  farnesyl diphosphate synthase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-11   farnesyl diphosphate synthase  Fdps  farensyl diphosphate synthase  Name updated 1299863 APPROVED
2002-06-10 Fdps  farensyl diphosphate synthase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the formation of geranyl- and farnesylpyrophosphate from the condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate  
gene_pathway part of isoprene biosynthetic pathway, which provides the cell with cholesterol, ubiquinone, dolichol, and other nonsterol metabolites 61515
gene_process functions in the isoprene biosynthetic pathway  
gene_regulation co-regulated with HMG-CoA synthase and HMG-CoA reductase 61515